Magnetic slow releasing diclofenac sodium prepn in supermolecular intercalation structure and its prepn

Abstract

The present invention is magnetic slow releasing diclofenac sodium in supermolecular intercalation structure and its preparation process, and belongs to the field of hydrotalcite material technology. The magnetic diclofenac sodium has the chemical expression of (M2+)1-x(N3+)x(OH)2(DIK-)a(Bn-)b.mH2O.kM'Fe2O4, and is prepared through the first coprecipitation process to prepare nanometer magnetic kernel, the subsequent mixing of the magnetic kernel with corresponding salt solution, and the final coprecipitation process to assemble diclofenac sodium into the hydrotalcite layers and to obtain the diclofenac sodium intercalated hydrotalcite with magnetic kernel. The magnetic slow releasing diclofenac sodium in supermolecular intercalation structure has high stability, raised bioavailability, capable of magnetic field location and targeting location and effective control on the medicine structure, composition, etc.

Description

technical field

[0001] The invention belongs to the technical field of hydrotalcite materials, in particular to a sustained-release diclofenac sodium with a magnetic supramolecular intercalation structure and a preparation method thereof. Background technique

[0002] Magnetic slow-release drugs are a kind of drugs that integrate magnetism and controlled release. When such drugs are used in the body, the magnetic field effect outside the body can guide the drug to move and concentrate in the body, and realize the controlled release of the drug. Therefore, such drugs are mainly used as carriers of anticancer drugs. Animal experiments and clinical observations have proved that magnetic drugs have a definite effect of inhibiting the growth of cancer cells, shrinking tumors of patients, and improving subjective symptoms.

[0003] Existing magnetic sustained-release agent medicine has following two classes: 1) magnetic sustained-release tablet is to add ferromagnetic powder in su...