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Blood vessel medicine support

A vascular stent and drug technology, applied in the field of medical devices, can solve the problem of the incidence of vascular restenosis not being effectively controlled, etc.

Inactive Publication Date: 2008-03-26
蔡绪旺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent No. ZL02100011.5 "a drug coating for coronary stents to prevent vascular restenosis" and patent No. ZL02156940.1 "a coating preparation method for drug-coated cardiovascular stents" are both in Efforts have been made in the above aspects, but the incidence of vascular restenosis after stenting has not been effectively controlled

Method used

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Experimental program
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Effect test

Embodiment 1

[0055] Embodiment 1: As shown in Figure 2, a porous adsorbed drug-coated stent, the surface of the stent 4 is coated with a polymer coating 6 with micropores 5, and the drug is absorbed on the polymer coating 6 by dip coating Microwell 5. Specifically: add 10g of tetraethyl orthosilicate (TEOS) to 10g of water, then add 0.1g of HCL, mix and disperse evenly at 40°C, form a sol in 2 hours, then spray on the surface of the stent, and then place the stent in an oven at 80°C, After curing for 24 hours, it was dried at 250-800° C. to densify it to form a porous silica gel ceramic-coated scaffold. Then soak the stent in a mixed solution of SIROLIMUS (sirolimus) and TACROLIMUS (tacrolimus) with a concentration of 10%-80% for 30 minutes. After taking out the stent, dry it under vacuum at 40°C to remove the paint, and then prepare SIROLIMUS (sirolimus) and TACROLIMUS (tacrolimus) drug-coated stents adsorbed by porous silica gel ceramics.

Embodiment 2

[0056] Embodiment 2: As shown in accompanying drawing 1, a sandwich-type embedded drug-coated stent, the surface of the stent is coated with a layer of pure polymer coating 1, and the polymer coating 1 is coated with a layer of drug coating 2. This layer is coated with a layer of biodegradable polymer or microporous polymer coating 3. Specifically: take 10 g of newly distilled methyl methacrylate monomer and put it into a clean dry conical flask, add initiator benzoyl peroxide (0.1% of monomer weight). In order to prevent water vapor from entering the Erlenmeyer flask during pre-polymerization, wrap a layer of cellophane on the mouth of the flask, and then tie it tightly with a rubber band. Heat the Erlenmeyer flask with a water bath at 80-90°C until the viscosity of the prepolymer in the bottle is close to that of glycerin, stop heating immediately and cool the prepolymer to room temperature with cold water. Spray this solution onto the stent. Put the film-coated stent abov...

Embodiment 3

[0057] Embodiment 3: As shown in accompanying drawing 1, a sandwich-type embedded drug-coated stent, the surface of the stent is coated with a layer of pure polymer coating 1, and the polymer coating 1 is coated with a layer of drug coating 2. A layer of biodegradable polymer microporous polymer coating 3 is applied outside the layer. Specifically: take 10 g of newly distilled methyl methacrylate monomer and put it into a clean dry conical flask, add initiator benzoyl peroxide (0.1% of monomer weight). In order to prevent water vapor from entering the Erlenmeyer flask during pre-polymerization, wrap a layer of cellophane on the mouth of the flask, and then tie it tightly with a rubber band. Heat the Erlenmeyer flask with a water bath at 80-90°C until the viscosity of the prepolymer in the bottle is close to that of glycerin, then stop heating immediately and cool the prepolymer to the room temperature with cold water. Spray this solution onto the stent. Put the film-coated s...

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Abstract

The present invention relates to a blood vessel medicine scaffold, including blood vessel scaffold, medicine and carrier, in which the medicine is coated on the surface of said blood vessel scaffold by means of carrier. The described medicine is rolimus medicine or mixture of rolimus medicine and taxol and / or hirudin, and said rolimus medicine is one of sirolimus, tacrolimus and eotarolimus or mixture of more than two kinds of them.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug-coated vascular expansion stent, which can effectively prevent postoperative restenosis and acute coagulation in the stent. Background technique [0002] Since the use of vascular stents as the main means of interventional treatment of cardiovascular and peripheral vascular occlusive lesions, this technology has developed rapidly, and currently accounts for more than 80% of the treatment of such diseases. However, the biggest defect of this technique is the occurrence of vascular restenosis and acute coagulation after stenting. From the current statistics, the incidence of restenosis after stenting is about 20%. The reason for vascular restenosis after stenting is that vascular smooth muscle cells are induced to proliferate excessively after the vascular intima injury caused by stent expansion, which leads to the hyperplasia of vascular intima, resulting in restenosis after ...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/12A61F2/90
Inventor 蔡绪旺
Owner 蔡绪旺
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