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Extruded 3D printed coating type sustained release preparation and preparation method thereof

A slow-release preparation and 3D printing technology, applied in the field of medicine and medicine, can solve the problems of unstable production process, inability to quickly deposit, and inability to extrude smoothly, and achieve a simple, stable and easy-to-adjust preparation method, and no obvious appearance and sustained-release properties. Change, slow release ideal effect

Active Publication Date: 2020-07-28
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large amount of ethanol not only needs to be produced for explosion protection; at the same time, the viscosity of the printing material changes with the volatilization of ethanol, and the production process is unstable; and the printed samples cannot be used directly, and need to be dried for 12-24 hours
To sum up, when using the existing slow-release materials for extrusion 3D printing, the amount of solvent added is small, the fluidity of the material is poor, and the material cannot be extruded smoothly; the amount of solvent added is large, the material is extruded smoothly, but it cannot be deposited quickly, and the printing poor body strength

Method used

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  • Extruded 3D printed coating type sustained release preparation and preparation method thereof
  • Extruded 3D printed coating type sustained release preparation and preparation method thereof
  • Extruded 3D printed coating type sustained release preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Example 1: Preparation and Evaluation of Diclofenac Sodium Sustained Release Preparation

[0030] Weigh 4.5g of gelatin, 0.9g of glycerin and 9.6g of water, and place them in a water bath at 55°C to fully mix and swell. Add 6.4g of diclofenac sodium and mix well to prepare the inner core material. Weigh 4.5g of gelatin, 0.9g of glycerin and 9.6g of water, and place them in a water bath at 55°C to fully mix and swell. Add 5g of HPMC K4M and mix evenly to prepare the coating material. Add the above materials into the barrel of the extrusion printer.

[0031] A cylindrical coated sustained-release preparation model was established, with an inner core diameter of 8.8 mm, a height of 4.5 mm, a coating wall thickness of 1.6 mm, a bottom thickness of 2.0 mm, and a top thickness of 2.0 mm. Coating printing parameters are: extrusion port diameter 0.8mm, layer height 0.5mm, extrusion temperature 45°C, printing speed 5mm / s, deposition temperature 25°C. Extrude the bottom 4 lay...

Embodiment 2

[0034] Example 2: Preparation and evaluation of different drug-coated sustained-release tablets

[0035]Weigh 3g of gelatin, 0.6g of glycerin and 6.4g of water, and place them in a water bath at 55°C to fully mix and swell. Add different drugs such as 6.8g of aminophylline, 4g of metoprolol tartrate or 1.1g of acetylsalicylic acid and mix them uniformly to prepare the inner core material. Weigh 3g of gelatin, 0.6g of glycerol and 6.4g of water, and place them in a water bath at 55°C to fully mix and swell. Add 3.4g HPMC and mix evenly to prepare coating material. Add the above materials into the barrel of the extrusion printer.

[0036] A cylindrical coated sustained-release preparation model was established, with an inner core diameter of 7.5 mm, a height of 4.5 mm, a coating wall thickness of 1.8 mm, a bottom thickness of 1.8 mm, and a top thickness of 1.8 mm. Coating printing parameters are: extrusion port diameter 0.6mm, layer height 0.3mm, extrusion temperature 45°C, p...

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Abstract

The invention belongs to the medical field of medicines, and relates to an extruded 3D printed coating type sustained release preparation and a preparation method thereof. According to the coating type sustained release preparation disclosed by the invention, a mixture of gelatin, glycerin and water is used as a substrate, a medicine or HPMC is added, an inner core or a coating is obtained, then through combination with model slicing and printing parameters, extruding and 3D printing are performed, and a target namely the coating type sustained release preparation is obtained. The formula hasgood printing properties, and takes account of smooth extruding and quick deposition; and compared with a conventional slow release printing material, the extruded 3D printed coating type sustained release preparation has the advantages that the water content of a system is reduced, and intensity and elasticity of samples are improved. An optimized coating model structure can solve the problems existing in a conventional extruded 3D printed sustained release preparation, including low medicine loading quantity, obvious early stage sudden release and not ideal 24h slow release actions. According to the extruded 3D printed coating type sustained release preparation disclosed by the invention, diclofenac sodium, aminophylline, metoprolol tartrate and acetylsalicylic acid are further used as representatives, the application effect of the coating type sustained release preparation is disclosed, and through adjusting medicines and models, individualized treatment of various medicines can berealized.

Description

technical field [0001] The invention belongs to the field of pharmaceutical medicine, and relates to a sustained-release pharmaceutical preparation, in particular to a coating-type sustained-release preparation and a preparation method for extrusion 3D printing. Background technique [0002] Different from fused deposition 3D printing, extrusion 3D printing based on semi-solid does not require high temperature operation, which is beneficial to the stability of drugs and the activity of biological protein drugs, and has great application prospects in the field of personalized pharmaceutical preparations. At present, there are mainly public studies on "extrusion 3D printing to prepare immediate-release preparations", and there are few studies on "extrusion 3D printing to prepare sustained-release preparations". The main reason is that the extrusion 3D printability of conventional pharmaceutical sustained-release materials is poor, and the sustained-release preparations prepare...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/24A61K9/36A61K9/40A61K47/38A61K47/42A61K47/10A61K31/196A61K31/522A61K31/138A61K31/616B33Y10/00B33Y70/10B33Y80/00
CPCA61K9/2013A61K9/2063A61K9/2072A61K9/282A61K9/2866A61K9/2873A61K9/2893A61K31/196A61K31/522A61K31/138A61K31/616B33Y10/00B33Y70/00B33Y80/00
Inventor 杨燕王晓月杨根生杨庆良
Owner ZHEJIANG UNIV OF TECH
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