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Racanisodamine eye drops

A technology of anisodamine and eye drops, applied in sensory diseases, active ingredients of heterocyclic compounds, drug combinations, etc., can solve the problems of large dosage of racemic anisodamine, poor reducibility, inconvenient use, etc., and achieve significant therapeutic effect , cost saving, and the effect of reducing the main drug content

Inactive Publication Date: 2007-01-24
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor reducibility of this type of gel, it is also inconvenient to use, because it must be used and stored at low temperature
[0013] Chinese patent 95112472.2 "Application of racemic anisodamine in the preparation of eye drops for the treatment of myopia" discloses a prescription for racemic anisodamine eye drops. The dosage of racemic anisodamine is large and the cost is high

Method used

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  • Racanisodamine eye drops

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] 100ml water for injection:

[0047] Racemic anisodamine 0.051g

[0048] Sodium hyaluronate 0.048g

[0049] Sodium chloride 0.84g

[0050] Benzalkonium chloride 0.01g

[0051] Process:

[0052] Sodium hyaluronate is added to the 1 / 4 (v / v) water for injection, and it swells at room temperature.

[0053] Dissolve sodium chloride and benzalkonium chloride in 1 / 2 (v / v) water for injection, then add the fully swollen sodium hyaluronate solution, stir evenly, and set aside.

[0054]After dissolving racemic anisodamine with 2mol / L dilute hydrochloric acid, add it to the above-mentioned mixed solution and stir evenly.

[0055] Adjust the pH to 4.0 with hydrochloric acid.

[0056] Add water for injection to the full amount, stir evenly, filter and fill.

Embodiment 2

[0058] 100ml water for injection:

[0059] Racemic anisodamine 0.06g

[0060] Sodium hyaluronate 0.045g

[0061] Boric acid 1.5g

[0062] Borax 0.3g

[0063] Methyl paraben 0.03g

[0064] Process:

[0065] 1. Add sodium hyaluronate to the 1 / 4 (v / v) water for injection, and swell at room temperature.

[0066] 2. Dissolve boric acid, borax, and benzalkonium chloride in 1 / 2 (v / v) water for injection, then add the fully swollen sodium hyaluronate solution, stir evenly, and set aside.

[0067] 3. Dissolve racemic anisodamine with 2mol / L dilute hydrochloric acid and add it to the above-mentioned mixed solution and stir evenly.

[0068] 4. Add water for injection to the full amount, stir evenly, filter and fill. The pH is 4.5.

Embodiment 3

[0070] 100ml water for injection:

[0071] Racemic anisodamine 0.10g

[0072] Sodium hyaluronate 0.039g

[0073] Sodium chloride 0.9g

[0074] Ethyl paraben 0.01g

[0075] Process:

[0076] 1. Add sodium hyaluronate to the 1 / 4 (v / v) water for injection, and swell at room temperature.

[0077] 2. Dissolve sodium chloride and benzalkonium chloride in 1 / 2 (v / v) water for injection, then add to the fully swollen sodium hyaluronate solution, stir evenly, and set aside.

[0078] 3. Dissolve racemic anisodamine with 2mol / L dilute hydrochloric acid and add it to the above-mentioned mixed solution and stir evenly.

[0079] 4. Adjust the pH to 5.8 with hydrochloric acid.

[0080] 5. Add water for injection to the full amount, stir evenly, filter and fill.

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PUM

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Abstract

The present invention discloses one kind of racanisodamine eye drops, which consist of water for injection in 100 ml, racanisodamine in 0.051-0.999g, sodium hyaluronate in 0.012-0.049g, and isoosmotic regulating agent 0.4-2.5g. The racanisodamine eye drops have obvious curative effect on near sightness. Animal experiment proves less irritation on eye and stable performance. The racanisodamine eye has small dosage and low cost.

Description

Technical field [0001] The invention relates to an eye drop preparation of racemic anisodamine. Background technique [0002] The 2000 epidemiological survey report of the Ministry of Education and the Ministry of Health showed that there were more than 300 million myopia patients in my country, among which 10 million were degeneration. The rate of myopia among students has ranked second in the world. The World Health Organization (WHO) has included the prevention and treatment of myopia in the global blindness prevention plan. Adolescents, especially lieutenant school students, have more myopia, including true myopia and pseudomyopia. Adolescent myopia has a lot to do with excessive eye use and visual fatigue. The key to prevention and treatment of young people's myopia is to prevent false myopia from turning into true myopia. The mainstream medicine for the prevention and treatment of adolescent myopia is eye drops containing racemic anisodamine. The theories about myopia are m...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61P27/10
Inventor 朱正鸣乌旭琼张冬梅夏凌云陈佩丽
Owner SHANGHAI SINE PHARMA LAB
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