Combined adjuvant for fish soaked vaccine and its application and use method

A technology of soaking vaccines and combined application, which is applied in the direction of medical formulas, medical preparations containing active ingredients, antibody medical ingredients, etc., can solve the problems of fish body injury, low work efficiency, and few products, and achieve improved immune effects, Easy to use and safe to use
CN101791403BInactive Publication Date: 2011-12-07YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
Publication Date
2011-12-07
Estimated Expiration
Not applicable · inactive patent

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Abstract

A combined adjuvant for soaked vaccines for fish and its application and use method, characterized in that the combined adjuvant is a combination of three adjuvants of dithiothreitol, vitamin D3 and racemic anisodamine, wherein dithiothreose Alcohol, vitamin D3 and racemic anisodamine are used at concentrations of 1-50mg / L, 0.1-20mg / L and 1-60mg / L respectively, and the synergistic effect is achieved in soaking vaccines including seawater and freshwater fish. immune effect. When using, first select fish to be immunized with a body weight of more than 2g per fish and with intact body surface; move the fish to be immunized into the dithiothreitol pretreatment solution with a concentration range of 1-50mg / L and soak for 1-20min, and then Add VD3 with a concentration range of 0.1-20mg / L and the vaccine to soak for 2-20 minutes, then add racemic anisodamine with a concentration range of 1-60mg / L and soak for 5-20 minutes. The invention significantly improves the immune effect of the vaccine, has simple and safe use method, low cost, does not need additional facilities and procedures, has no influence on the survival rate and growth speed of fish, and is also harmless to the environment and operators.
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Description

technical field

[0001] The invention relates to the immune prevention and control technology of marine biological diseases, in particular to a combination adjuvant for fish soaked vaccine and its application and use method. Background technique

[0002] The output of farmed fish in my country ranks first in the world, but the research and development of fish disease prevention and control technology is slow, and the developed fish disease prevention and control products cannot meet the needs of production, especially in the development and application of fish vaccines, which are currently available for fishery production. Not many products to choose to use. Therefore, the treatment of fish bacterial diseases in aquaculture relies too much on feeding antibiotics. As a result, long-term application of antibiotics will not only reduce the quality of aquatic products, but also lead to enhanced bacterial resistance, making it more difficult for future disease control. Foreign cou...

Claims

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