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Preparation of honokiol ophthalmic medicine and application of honokiol ophthalmic medicine in treatment of fungal keratitis

A technology of fungal keratitis and honokiol, which is applied in the field of drug preparation, can solve the problems of aggravated corneal tissue damage, low bioavailability, and delayed healing, so as to alleviate keratitis reactions, and the preparation method is easy to control and reduce The effect of intraocular pressure

Pending Publication Date: 2022-08-09
战璐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inflammatory response is conducive to the removal of pathogenic bacteria, but excessive inflammatory response can cause increased corneal tissue damage, delayed healing, and even blindness
Currently, natamycin, voriconazole, and amphotericin are commonly used clinically for the treatment of fungal keratitis. However, when used in the treatment of fungal keratitis, there are limitations such as low bioavailability and fungal drug resistance. Therefore, finding new and effective antifungal drugs is an arduous task for the treatment of fungal keratitis.

Method used

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  • Preparation of honokiol ophthalmic medicine and application of honokiol ophthalmic medicine in treatment of fungal keratitis
  • Preparation of honokiol ophthalmic medicine and application of honokiol ophthalmic medicine in treatment of fungal keratitis
  • Preparation of honokiol ophthalmic medicine and application of honokiol ophthalmic medicine in treatment of fungal keratitis

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The embodiment of the present invention provides Honokiol eye drops, specifically: potassium L-aspartate 130 μg / mL, vitamin B6 of 6.5 μg / mL, naphazoline hydrochloride 0.39 μg / mL, methyl sulfate Neostigmine 0.65μg / mL, L-menthol 0.16μg / mL, and honokiol 8μg / mL, the base component is a sterile injection containing 5-10% hydroxyethyl cellulose, eye drops Instill directly into the lower eyelid, 3-6 times a day, and the dosage for each administration should be greater than or equal to the volume of the conjunctival sac. The volume of the human conjunctival sac is usually 20 μL. When the dosage is greater than 20 μL, excess eye drops will overflow. A lot of waste will be caused. The Honokiol ophthalmic medicine of the present invention uses Honokiol as an active ingredient, as a fungal keratitis treatment drug, can effectively kill and kill the pathogenic fungi of fungal keratitis, and at the same time pass the naphthyl hydrochloride hydrochloride. Zolin is a vasoconstrictor to...

Embodiment 2

[0038] The difference between this embodiment and Example 1 is that a kind of Honokiol eye ointment includes Honokiol and excipient, more specifically:

[0039] S1: Put five parts of excipients into a tank water bath and heat to 30-50°C, until the excipients are completely melted, and keep the melting temperature;

[0040] S2: Slowly drop a portion of 40 mg / L Honokiol chloroform solution into the melted excipient, and continue to stir until the dropping is completed, until the solution is completely mixed with the excipient;

[0041] S3: After the mixing is completed, add the mixed medicine into a vacuum chamber with a stirring device, and at the same time as vacuuming, carry out continuous stirring to completely evaporate the chloroform.

[0042] The excipient is 99 parts of the matrix after heating and mixing 60-70% yellow petrolatum and 30-40% lanolin, adding 1 part of antioxidant vitamin E under the condition of 5-70 ℃, fully stirring and mixing to form, about approx. The...

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Abstract

The invention provides preparation of honokiol ophthalmic medicine and application of honokiol ophthalmic medicine in treatment of fungal keratitis, and relates to the technical field of medicine preparation. According to the preparation method of the ophthalmic medicine based on honokiol, honokiol eye drops are prepared, specifically, the honokiol eye drops comprise 130 [mu] g / mL of L-potassium aspartate, 6.5 [mu] g / mL of vitamin B6, 0.39 [mu] g / mL of naphazolin hydrochloride, 0.65 [mu] g / mL of neostigmine methyl sulfate, 0.16 [mu] g / mL of L-menthol and 8 [mu] g / mL of honokiol, and a substrate component is a sterile injection containing 5-10% of hydroxyethyl cellulose. The honokiol ophthalmic medicine disclosed by the invention takes honokiol as an effective component, can effectively kill pathogenic fungi of fungal keratitis as a medicine for treating fungal keratitis, does not damage corneal epithelium to generate a bad effect, does not cause toxic damage to ocular surface and promote tissue repair when being reasonably used, and has the advantages of simple preparation process, low cost and the like. The prognosis of a fungal keratitis patient is greatly facilitated.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to the preparation of honokiol ophthalmic medicine and its application in the treatment of fungal keratitis. Background technique [0002] Honokiol is a small molecule bisphenol extracted from the traditional Chinese medicinal material Magnolia officinalis. It is mainly derived from the dry bark, root bark and branch bark of Magnolia officinalis or Magnolia officinalis. , Long-lasting central muscle relaxation, central nervous system inhibition, anti-inflammatory, antibacterial, anti-pathogenic microorganisms, anti-ulcer, anti-oxidation, anti-aging, anti-tumor, lowering cholesterol and other pharmacological effects, for the treatment of acute enteritis. Bacillary dysentery Or amoebic dysentery. Chronic gastritis and so on. Among them, in terms of antibacterial effect, honokiol has significant antibacterial activity against Gram-positive bacteria, acid-fast bacteria, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4415A61K47/06A61P27/02A61P31/10A61K9/06A61K9/08A61K31/045A61K31/05A61K31/198A61K31/27A61K31/4164
CPCA61K31/4415A61K31/4164A61K31/198A61K31/045A61K31/27A61K31/05A61K9/06A61K9/08A61K9/0048A61K47/06A61P27/02A61P31/10A61K2300/00Y02A50/30
Inventor 战璐
Owner 战璐
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