56 results about "Potassium Aspartate" patented technology

A preparation method of potassium aspartate belongs to chemical field, which is characterized in that the invention adds potassium salt and aspartic acid into water to be reacted, removes part or all water, and adds residues into soluble non-aqueous solvent to precipitate solid to be broken and dried to obtain final product. Compared with prior art, the preparation method of potassium aspartate can improve product yield, reduce production cost, improve production efficiency and improve product quality.

A medicine in the form of injection, perfusion, tablet, capsule, or oral liquid for preventing and treating hypokalemia, early heartbeat and arrhythmia is prepared from levo-aminosuccinic acid (1-10 wt. portions), potassium salt (1-12) and auxiliary (0-100). Its advantages are sure curative effect, high stability and no pollution.

The invention relates to fertilizer, in particular to instant macroelement water-soluble fertilizer capable of increasing the soil organic matter content. The instant macroelement water-soluble fertilizer capable of increasing the soil organic matter content is prepared form components in parts by weight as follows: 100-200 parts of concentrated molasses yeast powder, 8-15 parts of poly potassium aspartate, 50-80 parts of citric acid, 3-10 parts of chitin, 30-50 parts of potassium carbonate, 10-30 parts of boric acid, 150-300 parts of urea, 200-400 parts of anhydrous dipotassium phosphate and 180-280 parts of ammonium polyphosphate. The fertilizer can be quickly dissolved, is fully water-soluble, can be applied to facility agriculture such as sprinkling and drip irrigation and the like and realizes integration of water and fertilizer and the efficiency of saving water, fertilizer and labor. The fertilizer can provide organic matters and various macroelement nutrients for soil and crops after usage.

The invention provides a method for preparing potassium L-aspartate. The method comprises the steps as follows: (1) using potassium carbonate or potassium hydroxide and L-asparaginic acid as raw materials; carrying out reaction with water served as the solvent and with the temperature of 70-80 DEG C; calibrating the pH (Potential of Hydrogen) of reacting liquid to reach 6.0 to 7.5 after the reaction; discoloring and filtering the reacting liquid, and concentrating until supersaturation reaches; cooling supersaturation liquid; and (2) transferring the cooled supersaturation liquid to a vacuum freeze drying machine; pre-freezing for 2 to 4 hours at -30 to -20 DEG C; then keeping for 3 to 5 hours at -25 to -15 DEG C; keeping the vacuum freeze drying machine in a vacuum condition with pressure of 4.5 to 6.5Pa. With the adoption of the technical scheme provided by the invention, organic solvent is not used, and therefore, the safety coefficient of production environment can be improved; the product is out of residual solvent, and the cost of the raw materials can be greatly reduced; and furthermore, the input for the equipment and field in the scheme is low; and the water in the product can be controlled well.

A levo-potassium magnesium aspartate freeze-dried powder injection consists of levo-potassium aspartate, levo-magnesium aspartate, freeze-dried power supporting agent and pH regulator. it is a kind of electrolyte extender, contains no crystal water, and has pH value of 5-11.5, large dosage, physical stability not affected by temperature and no pollution. It has wide application range, and is suitable for intravenously guttae to treat arrhythmia caused by various causes, chronic alcoholism fremitus, myocardiopathy as diabetes complication, etc. and application in heart operation. It is also suitable for acute and chronic hepatitis, intrahepatic cholestasis, and diseases of respiratory system, nerve system and metabolic system.

The invention discloses an aspartate transaminase mitochondrial isozyme detection kit, comprising: reagents 1: 0.02-0.5mol/L of buffer solution of which pH value is 6.5-8.0, 0.15-0.3mol/L of L-potassium aspartate, 0.3-5KU/L of malic dehydrogenase, 0.3-5KU/L of lactic dehydrogenase, 5-20mL/L of human cAST antibody, 0.01-3% of antibody stabilizer, 0.01-10% of enzyme stabilizer and 0.01-1% of preservative; and reagents 2: 0.02-0.5mol/L of buffer solution of which pH value is 7.0-9.0, 0.005-0.02mol/L of alpha-ketoglutarate, 0.1-0.5mmol/L of reduced coenzyme I, 0.01-1% of preservative and 0.01-10% of reduced coenzyme I stabilizer. The kit has the advantage of good stability.

A leveo-potassium magnesium aspartate infusion injection consists of levo-potassium aspartate, levo-magnesium asparatate, osmotic pressure regulator and pH regulator. It is a kind of electrolyte extender for infusion, and has pH value of 5-11.5, high concentration, large dosage, high stability and no pollution. it has wide application range, and is suitable for intravenously guttae to treat arrhythmia caused by various causes, chronic alcoholism fremitus, myocardiopathy as diabetes complication, etc. and applicaltion in heart operation. It is also suitable for acute and chronic hepatitis, intrahepatic cholestasis, and disease of respiratory system, nerve system and metabolic system.

The invention provides a preparation method of a potassium aspartate crude drug. The preparation method specifically comprises the following steps: (a), adding proper amount of purified water into a liquor preparation tank, adding a potassium salt under stirring, adding aspartic acid in a fractional manner while stirring after all potassium salt is dissolved, and reacting under stirring; (b), detecting that a pH value is between 5.8-8.2, and regulating by using proper amount of the potassium salt or aspartic acid if the detected value deviates from 5.8-8.2; (c), adding medicinal charcoal and stirring for 20 minutes-30 minutes; (d), enabling medical liquor to pass through a decarburization filter, filtering by a 0.45-mu m filter, monitoring and recording that pressure of the 0.45-mu m filter is between a range of 0.15 MPa-0.2 MPa, adding the purified water into the liquor preparation tank after the medical liquor is filtered out, feeding filtrate into a buffer tank by once to twice, and clarifying the filtrate; (e), spray-drying, discharging and sub-packaging.

The invention provides a potassium aspartate preparation method. The method comprises the following steps: 1, reacting aspartic acid with potassium hydroxide according to a mass ratio of 1:0.6-0.75; 2, carrying out three-stage filtration of a product obtained after the reaction in step 1 through one-time filtration by active carbon and two-time filtration by a filter membrane, and taking the obtained filtrate; 3, adding an organic solvent to the filtrate at -10-0DEG C, and cooling at -30 - -20DEGC; and 4, filtering, taking the obtained filter cake, and drying. The method allows the optimum water application amount to be obtained through the difference of the solubility of aspartic acid in water at different temperatures in order to reduce the solvent application amount and improve the yield. A filter system is increased to reduce impurities. A drying method is changed to select a best boiling drying method in order to reach the purposes comprising working hour saving, energy consumption reduction and effective water control. The method has the advantages of short production operation steps, low cost, short time consumption, high yield, and high content, and is very suitable for the industrialized production.

The invention relates to fertilizer, in particular to instant microelement water-soluble fertilizer capable of increasing the soil organic matter content. The instant microelement water-soluble fertilizer capable of increasing the soil organic matter content is prepared form components in parts by weight as follows: 450-550 parts of concentrated molasses yeast powder, 8-15 parts of poly potassium aspartate, 50-80 parts of citric acid, 20-40 parts of sodium bicarbonate, 20-40 parts of disodium octaborate tetrahydrate, 150-300 parts of zinc sulphate monohydrate, 100-200 parts of manganese sulfate, 5-15 parts of iron EDTA (ethylene diamine tetraacetic acid), 5-15 parts of copper EDTA and 0.5-1.5 parts of ammonium molybdate. The fertilizer can be quickly dissolved, is fully water-soluble, can be applied to facility agriculture such as sprinkling and drip irrigation and the like and realizes integration of water and fertilizer and the efficiency of saving water, fertilizer and labor. The fertilizer can provide organic matters and various microelement nutrients for soil and crops after usage.

The invention provides a method for preparing a potassium aspartate injection. The method comprises the following steps: (a) adding injection water accounting for 60-70 percent of the total volume of the preparation liquid into a concentrating preparation tank; (2) adding potassium aspartate into the concentrating preparation tank, stirring for 20-30 minutes until the potassium aspartate is completely dissolved, detecting and regulating the pH value to 4.5-9.5; (c) adding medicinal charcoal, stirring for 20-40 minutes at 70-90 DEG C, filtering the liquid medicine into a diluting preparation tank through a decarburization filter and a precise filter when the liquid medicine is hot; (d) adding injection water into the concentrating preparation tank, feeding the mixture to the diluting preparation tank through a filter to enable the liquid medicine in the diluting preparation tank to achieve the specific total volume of the preparation liquid; (e) stirring the liquid medicine in the diluting preparation tank for 5-10 minutes to lead the liquid medicine to be uniform, introducing the liquid medicine through a sterilization filter, and sampling to make intermediate inspection; (f) encapsulating and sterilizing.

The invention belongs to the field of medicine and particularly relates to a potassium magnesium aspartate injection and a preparation method thereof. The injection comprises raw and auxiliary materials in parts by weight as follows: 400-500 parts of potassium aspartate, 350-450 parts of magnesium aspartate and 10,000 parts of water for injection. The potassium magnesium aspartate injection overcomes the defect about batch charging for reaction of aspartate with sylvite (potassium hydroxide) and magnesium oxide and solves the problems about raw material dissolution in a storage process simultaneously. The invention further provides a preparation method of the potassium magnesium aspartate injection. The preparation method comprises the following steps: the water for injection accounting for 2/3 of the total volume of a prepared medical solution is added, and magnesium aspartate is added and stirred until magnesium aspartate is dissolved; potassium aspartate is added and stirred until potassium aspartate is dissolved; activated carbon is weighed and added to the solution, and the mixture is stirred for 15 min; the water for injection is added to the total volume, and uniform stirring is performed; filtered medical solution is subjected to heat-preservation storage at the temperature of 25-40 DEG C; the filtered medical solution is encapsulated in a glass ampule, and an intermediate product after encapsulation is subjected to sterilization and leak detection; the process is simple and easy to implement.

The invention relates to potassium magnesium aspartate freeze-dried powder preparation for injection. The potassium magnesium aspartate freeze-dried powder preparation for injection is prepared from the following materials in parts by weight: 400-600 parts of potassium aspartate, 400-600 parts of magnesium aspartate and 320-480 parts of lactose. The freeze-dried powder preparation disclosed by the invention has the advantages of being simple in prescription and scientific and reasonable in preparation method, so that the freeze-dried product is more fluffy and porous, thereby remarkably improving the re-dissolution of the freeze-dried powder preparation during the clinical use process; meanwhile, the stability of the preparation is further improved on the condition of low auxiliary material dosage and less categories, so that the medication safety of the patient is ensured.

The electrolyte replenishing medicine composition for injection contains potassium aspartate and magnesium aspartate in the weight ratio of 1 to 1 as effective components, mannitol as freeze drying excipient and pH regulator, with the ratio between total weight of potassium aspartate and magnesium aspartate and the weight of mannitol being 10 to 7.

The invention provides a potassium aspartate compound electrolyte injection and a preparation method thereof. The injection is 1000 mL in weight and comprises, by weight, 6.6-6.9g of sodium chloride;0.35-0.38g of calcium chloride; 0.65-6.9g of potassium aspartate, 0.18-0.22g of magnesium chloride; 3.1-3.4g of sodium acetate; 0.65-0.69g L-malic acid, 0.15-0.25g of sodium hydroxide and the balancewater. The aspartate is adopted in the anion of the injection, the chloride ion concentration can be further reduced, the ion composition is closer to the ratio of plasma electrolyte, and the plasma composition can be better matched. The acetate and malic acid are used as precursors of bicarbonate, balanced alkali residue is achieved, the risk of diluted acidosis is reduced; the liver burden is not aggravated, and the malic acid and aspartate can also play an auxiliary role in protecting liver function.

The invention discloses a preparation method of a magnesium potassium aspartate. The preparation method is characterized by comprising the following steps: (1) a step of preparing an potassium aspartate solution; (2) a step of preparing a magnesium aspartate solution; and (3) a step of preparing the magnesium potassium aspartate. The preparation method has the beneficial effects that the control degree of process parameters is high, the quality is stable, and detection results of potassium content and magnesium content in the magnesium potassium aspartate can be effectively ensured. The preparation method is simple to operate; the raw materials needed by the preparation method are cheap and are easily available; other impurities are not introduced in the process; a spray-dried product is moderate in particle size, high in mixing uniformity and stable in quality.

The invention provides a detection kit and a detection method for an aspartate aminotransferase mitochondrial isozyme. The kit consists of a reagent R1 and a reagent R2 which are mutually independent;the reagent R1 is prepared from the following components: 12-13g/L of TRIS buffer, 40-60g/L of L-potassium aspartate, 2.5-4KU/L of malate dehydrogenase, 15mg/L-25mg/L of anti-cell type AST monoclonalantibody, and 6-8g/L of NADH; a solvent for the reagent R1 is purified water; the reagent R2 prepared from the following components: 12-13g/L of TRIS buffer and 10-12g/L of alpha-ketoglutaric acid; asolvent for the reagent R2 is purified water. The detection kit and the detection method provided by the invention have the advantages of good quantitative ability, short time consumption, rapid batch detection, good repeatability, good stability, simple operation and low price, and can be applied to multi-brand clinical biochemical analyzers with open channels.

The invention relates to a composite growth promoter. The microbial agent contains Bacillus subtilis, Bacillus amyloliquefaciens, Bordetella sp., Sinorhizobium sp., Pseudomonas alcaligenes, Nitrobacteriaceae, actinomycete, Sporotrichum thermophile, potassium aspartate and gibberellin. The growth promoter provided by the invention can be used for improving agronomic characters of tobacco such as plant height, stem girth, maximum leaf length, maximum leaf width and effective number of leaves; the growth promoter can also be used for improving the accumulation of amount of dry matters of the tobacco in parts such as roots, stems, leaves and the like; and the composite growth promoter provided by the invention can be used for improving the quality of growth of the tobacco.

The invention discloses a Heparolysate injection pharmaceutical composition. The pharmaceutical composition is prepared from Heparolysate, vitamin C, potassium aspartate and magnesium aspartatse injection and polyethylene glycol 200. Low vitality stimulation indexes and limited treatment effects of the Heparolysate injection are overcome. The invention also discloses a preparation method of the pharmaceutical. The preparation method which has the characteristic of simple technology is suitable for industrialization production.

The invention relates to a method for preparing potassium aspartate semihydrate. In the method, asparaginic acid powder and anhydrous potassium carbonate powder are added into an organic solvent like methanol or acetone and the like according to the molar ratio of 2:1, stirring is performed for reaction, the suction filtration is carried out, and obtained solid powder is dried, so that the potassium aspartate is obtained. Compared with other technologies, the method has the advantages that the process is simple, the energy consumption is relatively low, the production cost is reduced, and the efficiency is improved.

The invention discloses a contact lens moisturizing and eye moistening liquid. The raw materials of the contact lens moisturizing and eye moistening liquid include, by weight, 2-3 parts of puerarin, 1-2 parts of Chrysanthemum morifolium extract, 1-2 parts of beta-carotene, 0.5-1 part of potassium aspartate, 1-1.5 parts of a vitamin additive, 0.5-1 part of taurine, 1-3 parts of sodium citrate, 1-2parts of sorbitol ester, 5-10 parts of a pearl liquid and 30-40 parts of ionized water. The eye moistening liquid has the ability to relieve eye fatigue and aches, resist radiation, moisturize, relieve eye dryness, eliminate inflammations and inhibit bacteria, and has certain effects on eye visual fatigue and eye dryness which are caused by long-time contact lens wearing.

The invention provides potassium aspartate compound electrolyte injection and a preparation method thereof. 1000 mL of injection comprises the following components in parts by weight: 3 to 15 g of sodium chloride, 0.1 to 0.2 g of potassium aspartate, 0.05 to 1.0 g of magnesium chloride, 0.2 to 5.0 g of sodium acetate, 0.2 to 3.0 g of calcium gluconate, 0.2 to 3.0 g of sodium citrate, 10 to 200 g of xylitol and the balance of water. The product is total intravenous nutritional injection, can provide various kinds of electrolyte and sugar for an organism simultaneously, and can fulfill the aimsof supplementing body fluid for the organism, maintaining water and electrolyte balance and providing energy. Furthermore, the potassium aspartate compound electrolyte injection does not depend on insulin metabolization, is very suitable for diabetics and hepatopath to use, is stable in metabolization, is particularly suitable for trauma and operation patients to use, promotes wound healing of theoperation and trauma patients and improves the immunologic function.