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Preparation method of magnesium potassium aspartate

A technology of potassium aspartate and magnesium aspartate, which is applied in the field of health care chemical preparation, can solve the problems that the ratio of amino acid to alkali equivalent is not easy to control, and the detection items such as potassium content and magnesium content are unqualified, etc. The effect of stable quality and high degree of control

Inactive Publication Date: 2018-12-21
SHANGHAI QINGPING PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that aspartic acid and inorganic base are added at one time, resulting in the problem that the equivalent ratio of amino acid and base is not easy to control, which will easily lead to the unqualified detection items such as potassium content and magnesium content of the final product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 777.5g of L-aspartic acid and 1.5L of pure water into the reaction vessel together, stir well until they are completely dissolved, then slowly add 358.7g of potassium hydroxide solid (1.09eq) while stirring, release heat, and cool to After room temperature, continue to stir until the system dissolves, and the pH of the solution is detected at room temperature (20-25v) to be 7.5-8.0, and finely filtered through a 0.45 μm pore-diameter filter membrane to obtain 3 L of L-aspartic acid potassium salt solution.

[0038] Add 922.6g of L-aspartic acid and 2L of purified water into the reaction vessel together, heat it to an inner temperature of 40°C, stir well until all are dissolved, and slowly add 165.8g of light magnesium oxide solid (0.59eq ), release heat, continue to stir until the system dissolves, cool to room temperature (20-25°C), check the pH of the solution to be 7.5-8.0, and fine filter with a 0.45 μm pore-diameter filter membrane to obtain 3.3 L of L-aspartic ...

Embodiment 2

[0043] Add 777.5g of L-aspartic acid and 1.5L of purified water into the reaction vessel together, stir well until they are completely dissolved, then slowly add 329.1g of potassium hydroxide solid (1.00eq) while stirring, release heat, and cool to After room temperature, continue to stir until the system dissolves. At room temperature (20-25° C.), the pH of the solution is detected to be 7.5-8.0, and finely filtered through a 0.45 μm pore-diameter filter membrane to obtain 3 L of L-aspartic acid potassium salt solution.

[0044] Add 922.6g of L-aspartic acid and 2L of purified water into the reaction vessel together, heat it to an inner temperature of 40°C, stir well until all are dissolved, and slowly add 210.8g of light magnesium oxide solid (0.75eq ), release heat, continue to stir until the system dissolves, cool to room temperature (20-25°C), check the pH of the solution to be 7.5-8.0, and fine filter with a 0.45 μm pore-diameter filter membrane to obtain 3.3 L of L-aspar...

Embodiment 3

[0049] Add 777.5g of L-aspartic acid and 1.5L of pure water into the reaction vessel together, stir well until they are completely dissolved, then slowly add 394.9g of potassium hydroxide solid (1.20eq) while stirring, release heat, and cool to After room temperature, continue to stir until the system dissolves. At room temperature (20-25° C.), the pH of the solution is detected to be 7.5-8.0, and finely filtered through a 0.45 μm pore-diameter filter membrane to obtain 3 L of L-aspartic acid potassium salt solution.

[0050]Add 922.6g of L-aspartic acid and 2L of purified water into the reaction vessel together, heat to an inner temperature of 40°C, stir well until all are dissolved, and slowly add 140.5g of light magnesium oxide solid (0.50eq ), release heat, continue to stir until the system dissolves, cool to room temperature (20-25°C), check the pH of the solution to be 7.5-8.0, and fine filter with a 0.45 μm pore-diameter filter membrane to obtain 3.3 L of L-aspartic acid...

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PUM

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Abstract

The invention discloses a preparation method of a magnesium potassium aspartate. The preparation method is characterized by comprising the following steps: (1) a step of preparing an potassium aspartate solution; (2) a step of preparing a magnesium aspartate solution; and (3) a step of preparing the magnesium potassium aspartate. The preparation method has the beneficial effects that the control degree of process parameters is high, the quality is stable, and detection results of potassium content and magnesium content in the magnesium potassium aspartate can be effectively ensured. The preparation method is simple to operate; the raw materials needed by the preparation method are cheap and are easily available; other impurities are not introduced in the process; a spray-dried product is moderate in particle size, high in mixing uniformity and stable in quality.

Description

technical field [0001] The invention belongs to the field of preparation of health care chemicals, and in particular relates to a preparation method of L-aspartic acid potassium magnesium salt. Background technique [0002] Potassium ions and magnesium ions are two essential trace elements for the human body, and their special physiological functions are critical to maintaining the normal metabolism of the human body. [0003] Potassium ions play a very important role in the synthesis and decomposition of glycogen, protein, and high-energy phosphates. When the body is deficient in potassium, fatigue, weakness, listlessness, and irritability may occur. In severe potassium deficiency, arrhythmia, striated muscle Lysis, and renal dysfunction, and even death. [0004] Magnesium ions are activators of various enzyme systems in the metabolism of human cells. All enzyme activation reactions that use thiamine pyrophosphate as a cofactor require the participation of magnesium ions. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/18C07C229/24
CPCC07B2200/07C07C227/18C07C229/24
Inventor 徐腾刘世领韦建国
Owner SHANGHAI QINGPING PHARMA CO LTD
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