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Laevo potassium aspartate material and preparation therefrom and preparing method thereof

A technology of potassium aspartate and aspartic acid, applied in chemical instruments and methods, preparation of cyanide reaction, preparation of organic compounds, etc. Storage and other issues, to achieve obvious curative effect and maintain metabolism

Inactive Publication Date: 2003-09-03
于航
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, there are many kinds of potassium supplements on the market for the prevention and treatment of potassium deficiency, but the effect is not obvious because the amount of potassium that can enter the cells is small
Some potassium supplements are greatly affected by light, heat, oxygen, and water, with unstable performance and inconvenient operation, transportation and storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) L-potassium aspartate raw material prescription: 1331 grams of L-aspartic acid, 560 grams of potassium hydroxide; 1712 grams of L-aspartate potassium raw material were obtained.

[0018] (2) Raw material preparation process: get the potassium hydroxide of prescription quantity and add in the reaction tank, dissolve with appropriate amount of water, then add 3kg of methanol or ethanol, then slowly add the L-aspartic acid of prescription quantity, stir while adding , use L-aspartic acid or potassium hydroxide to adjust the pH to 8, release the solution to filter, add the filtrate to the reaction tank, cool, then slowly add methanol or ethanol and stir, if necessary, add a small amount of L-aspartate potassium , Loose white crystalline L-aspartate potassium is precipitated from the solution, which is obtained after centrifugation and drying.

Embodiment 2

[0020] (1) Water injection prescription: 1712 grams of L-aspartate potassium, add water for injection to 10000 ml, and make 1000 sticks.

[0021] (2) The preparation process of water injection: take the prescribed amount of L-aspartate potassium, add an appropriate amount of water for injection and stir to dissolve, adjust the pH to 6.8, add 0.01-0.5% (W / V) activated carbon for needles, filter , add water for injection to the full amount, inspect, fill, melt seal, sterilize, light inspect, and pack.

Embodiment 3

[0023] (1) Prescription of freeze-dried powder injection: 1712 grams of L-aspartate potassium, 210 grams of mannitol, and 5000 ml of water for injection, made into 1000 sticks.

[0024] (2) The preparation process of freeze-dried powder injection: take the prescription amount of L-aspartate potassium and mannitol, add water for injection and stir to dissolve, adjust the pH to 6.8, add 0.1% active carbon for injection, stir at room temperature for 15min, filter Add water for injection to 3000ml, pass through a 0.2um microfiltration membrane, measure the content, and fill it into control bottles, each 3ml. Put the filled sample into a freeze dryer, first lower the temperature to -45°C, keep it warm for 2 hours, vacuumize after heating, and raise the temperature at about 2°C / hour, when the temperature reaches -5°C, press 5°C / hour Heat up to 25°C within 1 hour, keep warm for 2 hours, add rubber stoppers, tie covers, quality inspection, and pack.

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PUM

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Abstract

A medicine in the form of injection, perfusion, tablet, capsule, or oral liquid for preventing and treating hypokalemia, early heartbeat and arrhythmia is prepared from levo-aminosuccinic acid (1-10 wt. portions), potassium salt (1-12) and auxiliary (0-100). Its advantages are sure curative effect, high stability and no pollution.

Description

Technical field: [0001] The invention belongs to electrolyte replenishing medicine, in particular to a raw material of L-aspartate potassium and water injection, freeze-dried powder injection, transfusion, tablet, capsule, oral liquid and preparation method thereof prepared by using the raw material. Background technique: [0002] At present, there are many kinds of potassium supplements on the market for the prevention and treatment of potassium deficiency, but the curative effect is not obvious because the amount of potassium that can enter the cells is small. Some potassium supplements are greatly affected by light, heat, oxygen, and water, have unstable performance, and are not easy to operate, transport, and store. Invention content: [0003] In view of the deficiencies in the above-mentioned prior art, the purpose of the present invention is to provide a drug that is stable to light, heat, oxygen, water, etc., has no pollution, is easy to operate, transport and store...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/19A61K9/20A61K9/48A61K31/195A61P7/08A61P9/06C07C227/14C07C229/24
Inventor 于航
Owner 于航
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