Potassium aspartate medicine composition and preparation method
A technology of potassium aspartate and composition, which is applied in the directions of drug combination, drug delivery, and pharmaceutical formulation, can solve the problems of aggravating the disease condition and the large gap of sodium ions, and achieves the effect of low impurity content.
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Embodiment 1
[0023] Take 17.12 kg of potassium aspartate (calculated as anhydrous matter), add it to 75 L of water for injection, heat and stir to dissolve, and after all the dissolution is complete, adjust the pH to 6.9 with 5% potassium hydroxide solution, add water for injection to 100L, filtered through a 0.22μm microporous membrane, filled in borosilicate glass ampoules with 10ml each, sealed by melting, and sterilized at 121°C for 12 minutes to obtain the product.
Embodiment 2
[0025] Take 17.12 kg of potassium aspartate (calculated as anhydrous matter), add it to 75 L of water for injection deoxygenated with high-purity nitrogen, heat and stir under the protection of nitrogen gas under the liquid and the liquid surface to dissolve, and wait until it is completely dissolved , adjust the pH to 6.9 with 5% potassium hydroxide solution prepared by passing high-purity nitrogen deoxygenation, add water for injection deoxygenated with high-purity nitrogen gas to 100L, filter with a 0.22μm microporous membrane, and use 10ml each Fill in medium borosilicate glass ampoules, fill with nitrogen and seal, and sterilize at 121°C for 12 minutes.
Embodiment 3
[0027] Except that the sterilization process was 121 degrees for 8 minutes, other preparations were the same as in Example 1 to obtain potassium aspartate injection.
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