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Method for preparing potassium L-aspartate

A technology of potassium aspartate and aspartic acid, applied in chemical instruments and methods, cyanide reaction preparation, preparation of organic compounds, etc., can solve the problems of poor particle size, difficult control, high production cost, and achieve improved The effect of safety factor, reduction of raw material cost, and reduction of site investment

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first method: the use of organic solvents reduces the safety factor of the production environment, and organic solvents are likely to remain in the obtained products, and the use of organic solvents for extraction will increase production costs
The second extraction method has equipment, large site investment, and high production costs; the particle size of the obtained product is poor, the moisture content is unstable, and it is difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add potassium carbonate. Potassium carbonate needs to be added slowly to prevent excessive foaming and liquid splashing Wherein the mass of L-aspartic acid is 20% of the water mass, and the mass ratio of L-aspartic acid to potassium carbonate is 2:1.

[0016] Take a small amount of reaction solution to filter and remove impurities, then test the pH, and correct the pH of the reaction solution to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it down to room temperature, at this time the material is extremely Viscous, but no crystallization.

[0017] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -25°C for 3 hours, then set the temperature at -20°C and maintain...

Embodiment 2

[0019] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add potassium hydroxide. Potassium hydroxide should be added slowly to prevent excessive foaming The liquid is splashed; the mass of L-aspartic acid is 20% of the mass of water, and the mass ratio of L-aspartic acid to potassium hydroxide is 2:1.

[0020] Take a small amount of reaction solution to filter and remove impurities, then test the pH, and correct the pH of the reaction solution to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it down to room temperature, at this time the material is extremely Viscous, but no crystallization.

[0021] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -30°C for 2.5 hours, then set the temperature at -25°C and maintain i...

Embodiment 3

[0023] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add potassium carbonate. Potassium carbonate needs to be added slowly to prevent excessive foaming and liquid splashing Wherein the mass of L-aspartic acid is 20% of the water mass, and the mass ratio of L-aspartic acid to potassium carbonate is 2:1.

[0024] Take a small amount of reaction solution to filter and remove impurities, then test the pH, and correct the pH of the reaction solution to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it down to room temperature, at this time the material is extremely Viscous, but no crystallization.

[0025] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -20°C for 4 hours, then set the temperature at -15°C and maintain...

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Abstract

The invention provides a method for preparing potassium L-aspartate. The method comprises the steps as follows: (1) using potassium carbonate or potassium hydroxide and L-asparaginic acid as raw materials; carrying out reaction with water served as the solvent and with the temperature of 70-80 DEG C; calibrating the pH (Potential of Hydrogen) of reacting liquid to reach 6.0 to 7.5 after the reaction; discoloring and filtering the reacting liquid, and concentrating until supersaturation reaches; cooling supersaturation liquid; and (2) transferring the cooled supersaturation liquid to a vacuum freeze drying machine; pre-freezing for 2 to 4 hours at -30 to -20 DEG C; then keeping for 3 to 5 hours at -25 to -15 DEG C; keeping the vacuum freeze drying machine in a vacuum condition with pressure of 4.5 to 6.5Pa. With the adoption of the technical scheme provided by the invention, organic solvent is not used, and therefore, the safety coefficient of production environment can be improved; the product is out of residual solvent, and the cost of the raw materials can be greatly reduced; and furthermore, the input for the equipment and field in the scheme is low; and the water in the product can be controlled well.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a method for preparing potassium L-aspartate. Background technique [0002] Potassium L-aspartate has significant curative effects in regulating myocardial function and electrophysiology, treating cardiovascular and cerebrovascular diseases, hypokalemia and other arrhythmias, hepatitis, and liver insufficiency. It is a pharmaceutical intermediate, which can be used as food additive and biochemical research preparation. The ingredients and concentration of the existing production process are exactly the same, and the difference is mainly the difference in the extraction method. The extraction process of L-potassium aspartate in the existing production process is: using an organic solvent to change the polarity of the solvent, so that the product is precipitated or the method of spray drying is used to directly obtain the finished product. The first method: the use o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/24C07C227/18
Inventor 席日新李海涛
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