Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of potassium aspartate semihydrate

A technology of potassium aspartate and aspartic acid, which is applied in the field of synthesis of known compounds, and can solve the problems of unsuitable tablets and high energy consumption

Inactive Publication Date: 2015-11-11
ANHUI WANBANG MEDICAL TECH
View PDF6 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Both the freeze-drying method and the spray-drying method mentioned above have the disadvantage of high energy consumption. In addition, the prepared product may be an amorphous powder with strong hygroscopicity, which is not suitable for the preparation of tablets.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Add 1.5 L of methanol to a 2 L three-necked flask, add 56.1 g (1.0 mol) of potassium hydroxide and 133.1 g (1.0 mol) of aspartic acid under slow stirring, and stir at room temperature for 12 hours. After suction filtration and drying, 168.2 g of aspartic acid potassium salt hemihydrate was obtained, with a yield of 93.3%.

Embodiment 2

[0013] Add 2.0 L of methanol to a 3 L three-necked flask, add 74.8 g (1.33 mol) of potassium hydroxide and 177.5 g (1.33 mol) of aspartic acid under slow stirring, and stir at room temperature for 12 hours. After suction filtration and drying, 228.7 g of aspartic acid potassium salt hemihydrate was obtained, with a yield of 95.2%.

Embodiment 3

[0015] Add 3.0 L of methanol to a 5 L three-necked flask, add 112.2 g (2.0 mol) of potassium hydroxide and 266.2 g (2.0 mol) of aspartic acid under slow stirring, and stir at room temperature for 12 hours. After suction filtration and drying, 338.0 g of aspartic acid potassium salt hemihydrate was obtained, with a yield of 93.8%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing potassium aspartate semihydrate. In the method, asparaginic acid powder and anhydrous potassium carbonate powder are added into an organic solvent like methanol or acetone and the like according to the molar ratio of 2:1, stirring is performed for reaction, the suction filtration is carried out, and obtained solid powder is dried, so that the potassium aspartate is obtained. Compared with other technologies, the method has the advantages that the process is simple, the energy consumption is relatively low, the production cost is reduced, and the efficiency is improved.

Description

technical field [0001] The present invention relates to a kind of synthetic method of known compound, more specifically relate to a kind of synthetic method of potassium aspartate hemihydrate. Background technique [0002] Potassium L-aspartate has significant curative effects in regulating myocardial function and electrophysiology, and treating cardiovascular and cerebrovascular diseases, hypokalemia and other arrhythmias, hepatitis, liver insufficiency, etc. It is a pharmaceutical intermediate. Potassium aspartate for medicinal use recorded in European Pharmacopoeia EP7.0 is the hemihydrate of L-aspartic acid monopotassium salt, and its molecular formula is C 4 h 6 KNO 4 1 / 2H 2 O, molecular weight 180.2. Potassium aspartate with this structure has relatively stable physical and chemical properties, and is suitable for raw materials for tablets and injections. [0003] The preparation method of aspartic acid potassium salt reported in the literature is mainly obtained ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/24C07C227/18
Inventor 陈国祥陶春蕾邵凤杨欣怡王慧束超
Owner ANHUI WANBANG MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com