Method for solid-phase synthesis of potassium aspartate at room temperature

Abstract

The invention relates to a method for solid-phase synthesis of potassium aspartate at a room temperature. The method comprises the following steps: uniformly mixing asparaginic acid powder with sheet potassium hydroxide according to a mole ratio of 1: 2, carrying out reaction during the mixing to generate the potassium aspartate, and directly drying and grinding to obtain the potassium aspartate powder. The method is simple in process and low in energy consumption, and is capable of improving the production efficiency and reducing the production cost.

Description

technical field [0001] The invention relates to a method for synthesizing potassium aspartate in solid phase at room temperature. Mix aspartic acid powder and block or flake potassium hydroxide at a molar ratio of 1:2, and react to synthesize potassium aspartate while mixing. Background technique [0002] Potassium aspartate molecular formula C 4 h 5 K 2 NO 4 , molecular weight 209.28. Potassium aspartate has significant curative effects in regulating myocardial function and electrophysiology, and treating various arrhythmias such as cardiovascular and cerebrovascular diseases, hypokalemia, hepatitis, and liver insufficiency. It is an important pharmaceutical intermediate and can also be used as a biochemical research preparation. [0003] The traditional potassium aspartate production process mainly uses water as the medium. Aspartic acid reacts with potassium hydroxide or potassium carbonate in an aqueous solution to form a potassium aspartate solution, which is the...

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Problems solved by technology

[0004] The above-mentioned production process has the disadvantages of many process steps, large water consumption, and high drying energy consumption.