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Electrolyte complementary medical combination for injection

A technology for composition and injection, applied in the direction of drug combination, pharmaceutical formula, medical preparations with non-active ingredients, etc., can solve the problems of high energy consumption, high cost, and failure to meet the use requirements

Active Publication Date: 2007-09-12
西藏中卫诚康药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For lyophilized preparations, there are problems such as high energy consumption and high cost in the preparation process. How to optimize the preparation prescription and preparation process, improve the formability and quality of lyophilized preparations under the premise of reducing energy consumption, and reduce the cost of clinical use. Pain and the incidence of adverse reactions are important issues in the preparation of lyophilized powder for injection
And the currently disclosed pharmaceutical composition can not meet the requirements for use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] prescription:

[0014] Potassium Aspartate 500g

[0015] Magnesium Aspartate 500g

[0016] Mannitol 500g

[0017] 0.2mol / L potassium hydroxide appropriate amount

[0018] Water for injection 4L

[0019] Preparation Process:

[0020] In the aseptic operation room, weigh potassium aspartate, magnesium aspartate and mannitol according to the prescribed amount, add them to water for injection with 75% of the prescribed amount in sequence, heat to about 60°C, and stir to dissolve; add the prepared Measure 0.5% (g / ml) of activated carbon, keep stirring at 60°C for 30 minutes, use a 1.2 μm mixed cellulose ester microporous membrane to filter roughly, wash the activated carbon layer with a small amount of water (about 5% of the prescription amount), and wash the activated carbon layer with 0.2 mol / L potassium hydroxide solution to adjust the pH to 5.6-6.2 (as long as the raw material drug is put in according to the prescription amount, generally no adjustment is required),...

Embodiment 2

[0022] prescription:

[0023] Potassium Aspartate 500g

[0024] Magnesium Aspartate 500g

[0025] Mannitol 700g

[0026] 0.2mol / L potassium hydroxide appropriate amount

[0027] Water for injection 4L

[0028] Preparation process: same as embodiment 1 preparation process.

Embodiment 3

[0030] prescription:

[0031] Potassium Aspartate 500g

[0032] Magnesium Aspartate 500g

[0033] Mannitol 900g

[0034] 0.2mol / L potassium hydroxide appropriate amount

[0035] Water for injection 5L

[0036] Preparation process: same as embodiment 1 preparation process.

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PUM

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Abstract

The electrolyte replenishing medicine composition for injection contains potassium aspartate and magnesium aspartate in the weight ratio of 1 to 1 as effective components, mannitol as freeze drying excipient and pH regulator, with the ratio between total weight of potassium aspartate and magnesium aspartate and the weight of mannitol being 10 to 7.

Description

technical field [0001] The invention relates to electrolyte replenishing medicine, in particular to a powder composition for injection with a mass ratio of potassium aspartate and magnesium aspartate calculated on the basis of anhydrous matter of 1:1, and a preparation method and application of the composition. Background technique [0002] Potassium Magnesium Aspartate is a mixture of Potassium and Magnesium Aspartate, an electrolyte supplement. Magnesium and potassium are important cations in cells, which play an important role in various enzyme reactions and muscle contraction. The ratio of the concentrations of potassium ions, calcium ions, sodium ions, and magnesium ions inside and outside cells affects myocardial contractility. Aspartate is the precursor of oxaloacetate in the body and plays an important role in the Krebs cycle. At the same time, aspartic acid also participates in the ornithine cycle, promotes the metabolism of ammonia and carbon dioxide, makes it gen...

Claims

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Application Information

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IPC IPC(8): A61K31/198A61K9/14A61K9/19A61K47/10A61P3/12A61P9/10A61P9/06A61P9/04
Inventor 刘烽杨莙华张勇
Owner 西藏中卫诚康药业有限公司
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