The invention discloses a prevention and control method for continuous cropping barriers of atractylodes macrocephala. The method comprises the steps of land selection, plowing, seed selection and seedling raising, field management, flower bud removing and harvesting, wherein a land with an appropriate slope after first-stubble atractylodes macrocephala is harvested and before the second-stubble atractylodes macrocephala is cultivated is selected for planting corn and soybeans; after preceding plants are harvested and turned over, sheep dung and cow dung are uniformly spread on the plants, then quick lime is spread, and full decomposing, ploughing and drying are carried out; a soil continuous cropping agent is added before transplanting, and ploughing is carried out again; then a broad-leaf high-pole atractylodes macrocephala strain is selected, from first frost to beginning of winter, the atractylodes macrocephala without diseases and insect pests and with plump bud heads at the top end and the weight of 9-12 grams is selected as seed atractylodes macrocephala, then 8000-15000 of basic seedlings are planted on ridges every mu and intercropped with corn; finally, field weed prevention and control, fertilization and field drainage and irrigation are carried out. By using the method, important traits such as plant height, crown breadth, stem diameter, leaf length, leaf width andbranching number are significantly improved, the occurrence of the soil borne root rot is reduced, and the content of atractylenolide is increased.