30results about How to "Small inter-individual differences" patented technology

The invention relates to an optic-fiber temperature/humidity sensor and the manufacturing method and application for the sensor. The optic-fiber temperature/humidity sensor is characterized in that, the sensor comprises an optic-fiber core with a refractivity of 0 and a sensing cladding layer with a refractivity of nc, and the sensing cladding layer contains at least one polymer or low-molecular material whose refractivity will change with temperature/humidity; the optic fiber is a glass or plastic optic fiber, the core diameter is 5 micrometer-3mm; the thickness of the sensing cladding layer is 0.1-30 micrometer, length not more than 20 cm. The sensor uses the optic-fiber core in the invention; and after the sensing cladding layer is heated to be completely molten in the solvent, the melt is cooled to 20-60 centigrade, then the solvent is evenly coated on the outer surface of the glass or plastic optic-fiber core; after airing, heat treatment or cross-link treatment, the sensor is obtained.

The invention discloses a steady-state motion visual evoked potential (SSMVEP) brain-computer interface method based on a CSFL-GDBN. According to the method, first, hardware connection is performed, and then SSMVEP data with tags is collected to train the CSFL-GDBN so that the CSFL-GDBN can perform effective classification on SSMVEP signals, wherein the CSFL-GDBN is formed by stacking GRBMs and RBMs; multi-GRBM training is performed on data from different channels on an input data layer on the bottom layer of the CSFL-GDBN, and signal features of all the channels are extracted; next, extracted subchannel features are fused on a next feature fusion layer; and last, the fused features are classified after being abstracted again to obtain excitation target information of SSMVEP. Through the method, the signal features can be automatically extracted, useful information is not prone to loss, the multichannel fusion mechanism enables the extracted features to contain spatial information in multichannel brain electrical signals, and the method has the advantages that recognition speed is high, and recognition accuracy is stable among individuals.

The invention provides a method for breeding thick-shell field snails, in particular to the technical field of aquaculture. The method comprises the following steps: a, snails pond construction: building a snails pond where water source is sufficient and water quality is fresh and clean, and stacking straw at the edge of the pond; b, larval snails throwing: throwing thick-shell larval snails intothe snails pond, feeding the snails with larval snails bait, selecting the preferred larval snails after screening; c. feeding management: feeding the preferred larval snails until they develop into adult snails with a body weight of 22-34g; d, retention breeding and harvesting: carrying out the retention breeding by selecting adult snails individuals with a body weight of 24-34g and a shell thickness of 0.7 cm or more according to the ratio of male to female of 4-5:1-2. The thick-shell field snails bred by the method have the advantages of large size body, thick outer shell, convenient transportation, crisp and fresh taste, high survival rate and stable quality. The breeding process is simple and easy, the elimination rate is low, the management is convenient, and the method is easy to promote.

The invention provides a butylphthalide preparation and a preparation method thereof. Specifically, the invention provides the butylphthalide preparation, and oleic acid is used as a solubilizing auxiliary material, so that the oral bioavailability of the butylphthalide preparation is improved, the individual difference is reduced, and the adverse reaction is reduced. The preparation has the advantages of being good in medicine stability, convenient to package, transport and store and the like, the preparation process is simple, and industrial production is easy.

The invention belongs to the field of medicinal preparations, and in particular relates to a dalanthamine hydrobromide dispersible tablet and a preparation method thereof. Due to low bioavailability of dalanthamine hydrobromide in oral absorption and large difference among administration individuals, the dalanthamine hydrobromide dispersible tablet comprises dalanthamine hydrobromide, hydroxypropyl-beta-cyclodextrin, packing, a disintegrating agent, an adhesive and a lubricant. Dalanthamine hydrobromide is easily dissolved in water after being included by hydroxypropyl-beta-cyclodextrin (HP-beta-CD), so that the medicinal stability can be improved, in-vivo release of the medicament can be accelerated, absorption can be improved, bioavailability can be improved, and difference among administration individuals can be reduced.

The invention relates to a carcinogenic mouse model and an establishment method and application thereof, and belongs to the technical field of animal models. The mouse model is obtained by transferring a vector containing a human protooncogene c-Ha-ras (HRAS) gene sequence fragment into C57BL/6 mouse embryonic stem cells, performing blastocyst injection, transplanting into a receptor mouse and performing screening. According to the mouse model, a stem cell targeting technology is adopted, a transgenic vector for highly expressing human proto-oncogene is established and subjected to fixed-point insertion, the mouse model is obtained through construction, C57BL/6 stem cells are directly used as a mouse background, a fixed-point insertion model with the pure C57BL/6 background can be directly obtained without long backcross, and the obtained mouse model is more uniform and better in result consistency.

The invention provides a method for breeding thick-shell river snails, and particularly relates to the technical field of aquaculture. The method comprises the following steps of: a, building a riversnail pool, specifically, a place with sufficient water source and fresh and clean water quality is selected to build the river snail pool; b, selecting and rearing river snail parents, specifically,a stone snail is chosen as a male parent and a river snail is chosen as a female parent; c, breeding young river snails, specifically, the individual young river snails with the shell thickness of 60-80 mm are selected from a first generation produced by the female parents, and hybridization is carried out according to the ratio of female to male of 4-5: 1 to produce a second generation of the young river snails; d, rearing and screening the young river snails, specifically, dead river snails and the river snails with holes at the tails of the second generation of the young river snails are weeded out to obtain the thick-shell river snails; and e, breeding the thick-shell river snails, specifically, the thick-shell river snails are raised to 8-12 months of age and then the thick-shell river snails for the breeding of a next generation of the river snails are reserved according to the ratio of female to male of 4-5: 1. According to the method, the bred thick-shell river snails have theadvantages of being large in body size, thick in shell, convenient to transport, crisp in mouth feeling, fresh and sweet in taste, high in survival rate and stable in quality; and the breeding processof the method is simple and feasible, the elimination rate is low, the management is convenient, and easy to be popularized.