30results about How to "Small inter-individual differences" patented technology

The invention relates to an optic-fiber temperature / humidity sensor and the manufacturing method and application for the sensor. The optic-fiber temperature / humidity sensor is characterized in that, the sensor comprises an optic-fiber core with a refractivity of 0 and a sensing cladding layer with a refractivity of nc, and the sensing cladding layer contains at least one polymer or low-molecular material whose refractivity will change with temperature / humidity; the optic fiber is a glass or plastic optic fiber, the core diameter is 5 micrometer-3mm; the thickness of the sensing cladding layer is 0.1-30 micrometer, length not more than 20 cm. The sensor uses the optic-fiber core in the invention; and after the sensing cladding layer is heated to be completely molten in the solvent, the melt is cooled to 20-60 centigrade, then the solvent is evenly coated on the outer surface of the glass or plastic optic-fiber core; after airing, heat treatment or cross-link treatment, the sensor is obtained.

The invention belongs to the field of medicine preparations, which in particular relates to a dispersing tablet of valsartan and a preparation method thereof. Because the valsartan has lower bioavailability when being orally taken and absorbed and larger difference between application individuals, the invention provides the dispersing tablet of the valsartan, which contains the valsartan, hydroxy propyl-beta-schardinger dextrin, a filling agent, a disintegrating agent, an adhesive and a lubricant. After the valsartan is included by the hydroxy propyl-beta-schardinger dextrin (HP-beta-CD), the valsartan is very easy to dissolve in water, enhances the stability of the medicine, promotes the in-vivo release of the medicine, increases the absorption, enhances the bioavailability and lowers the difference between the application individuals.

The invention discloses an ivermectin transdermal liniment for animals, which is prepared from medicinal liquor and ivermectin, wherein the medicinal liquor is prepared from the following components in percentage by volume: 20-40% of ethyl acetate, 2-5% of azone and 55-75% of propylene glycol; and the ratio of ivermectin to medicinal liquor is (0.5-1g):100mL. The novel transdermal accelerator selected in the formula can enhance the absorption of skin for medicines, does not have toxicity or irritation on the skin and body, does not have pharmacological action, and does not react with the medicines and other additives. The invention is simple to prepare and convenient to use, has high stability, and can achieve favorable anthelminthic effect.

The invention relates to a multi-focus image fusion method and belongs to the field of image processing. An enhanced differential evolution method and an image fusion method of an expansion block selection mechanism are adopted in the multi-focus image fusion process. Compared with a standard differential evolution method, the enhanced differential evolution method is used for judging population after iteration every time according to the sizes of images and interval initial population; one individual is reserved on the premise that all the individuals in the population are the same; the restindividuals are reinitialized and served as a new generation of population together in the corresponding interval by an initialization method of a standard differential evolution algorithm, and localsearch is enhanced, so that the optimal block size of the image is acquired; in addition, when the fitness of image blocks is equal, extension blocks are selected, and the fused image blocks are acquired by comparing. According to the multi-focus image fusion method, the efficiency of searching the optimal block size in the process of the image fusion is improved, and the computational complexityis reduced; and in addition, the clarity of the whole fused image is fully considered in the process of the image fusion.

The invention discloses a steady-state motion visual evoked potential (SSMVEP) brain-computer interface method based on a CSFL-GDBN. According to the method, first, hardware connection is performed, and then SSMVEP data with tags is collected to train the CSFL-GDBN so that the CSFL-GDBN can perform effective classification on SSMVEP signals, wherein the CSFL-GDBN is formed by stacking GRBMs and RBMs; multi-GRBM training is performed on data from different channels on an input data layer on the bottom layer of the CSFL-GDBN, and signal features of all the channels are extracted; next, extracted subchannel features are fused on a next feature fusion layer; and last, the fused features are classified after being abstracted again to obtain excitation target information of SSMVEP. Through the method, the signal features can be automatically extracted, useful information is not prone to loss, the multichannel fusion mechanism enables the extracted features to contain spatial information in multichannel brain electrical signals, and the method has the advantages that recognition speed is high, and recognition accuracy is stable among individuals.

The invention belongs to the field of a pharmaceutical preparation, and specifically relates to enzalutamide tablets and a preparation method thereof. The enzalutamide tablets comprise enzalutamide, hydroxypropyl-beta-cyclodextrin, a filler, a disintegrating agent, an adhesive, and a lubricant. Enzalutamide coated with hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is extremely easy to be dissolvedin water. The stability of the tablets is improved, release of the medicine in the body is promoted, absorption is improved, and the bioavailability is increased.

The invention belongs to the field of medical preparations, and particularly relates to a rosuvastatin calcium dispersible tablet and a preparation method thereof. Rosuvastatin calcium is low in bioavailability after being orally taken and absorbed, and the individuals for medication have large difference, therefore, the invention provides the rosuvastatin calcium dispersible tablet which comprises rosuvastatin calcium, hydroxypropyl-beta-cyclodextrin, a filler, a disintegrating agent, a binder and a lubricant. Rosuvastatin calcium is easily dissolved into water after being coated by hydroxypropyl-beta-cyclodextrin (HP-beta-CD), the stability of the tablet can be enhanced, the release and absorption of the drug in a human body can be promoted, the bioavailability can be improved, and the difference of the individuals for medication can be reduced.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a cisapride dispersible tablet and a preparation method thereof. As the cisapride is low in bioavailability via oral administration and the difference between the pharmacy individuals is relatively large, the invention provides the cisapride dispersible tablet which comprises cisapride, hydroxypropyl-beta-cyclodextrin, a filling agent, a disintegrating agent, a binding agent and a lubricant. The cisapride is extremely easily dissolved in water after being included by the hydroxypropyl-beta-cyclodextrin (HP-beta-CD), so that the drug stability is improved, the release of the drug in vivo is promoted, the absorption is increased, the bioavailability is improved and the difference between the pharmacy individuals is reduced.

The invention discloses a device loaded with a structured catalyst with radial wall flow. According to the invention, a plurality of structural units are loaded in a reaction tube. Each structural unit comprises a reactant stream wall flow guide panel, a structured carrier loaded with a catalyst, and an expansion ring with a thermal expansion and contraction effect. The reactant stream wall flow guide panel is arranged at the top end of the structured carrier loaded with the catalyst. The bottom end of the structured carrier loaded with the catalyst is embedded in the expansion ring with thermal expansion and contraction effect. The reactant stream wall flow guide panel is a solid cylindrical body coaxial with the structured carrier loaded with the catalyst. The expansion ring with thermal expansion and contraction effect is a hollow cylindrical body coaxial with the structured carrier loaded with the catalyst. The cross-sections of two hollow parts are overlapped. The device provided by the invention has the advantages of simple structure, low pressure drop, and uniform fluid distribution. With the device, advantages of the structured catalyst in the aspects of heat transfer and mass transfer can be fully performed. Material stream radial wall flow can be realized. The device can be used in industrialized production for producing propylene from methanol.

The invention provides a method for breeding thick-shell field snails, in particular to the technical field of aquaculture. The method comprises the following steps: a, snails pond construction: building a snails pond where water source is sufficient and water quality is fresh and clean, and stacking straw at the edge of the pond; b, larval snails throwing: throwing thick-shell larval snails intothe snails pond, feeding the snails with larval snails bait, selecting the preferred larval snails after screening; c. feeding management: feeding the preferred larval snails until they develop into adult snails with a body weight of 22-34g; d, retention breeding and harvesting: carrying out the retention breeding by selecting adult snails individuals with a body weight of 24-34g and a shell thickness of 0.7 cm or more according to the ratio of male to female of 4-5:1-2. The thick-shell field snails bred by the method have the advantages of large size body, thick outer shell, convenient transportation, crisp and fresh taste, high survival rate and stable quality. The breeding process is simple and easy, the elimination rate is low, the management is convenient, and the method is easy to promote.

The invention belongs to the field of pharmaceutical preparations and in particular relates to pravastatin sodium dispersible tablets and a preparation method thereof. Because the oral absorption bioavailability of pravastatin sodium is low, and the difference between medication individuals is large, the invention provides pravastatin sodium dispersible tablets. The pravastatin sodium dispersible tablets contain pravastatin sodium, hydroxypropyl-beta-cyclodextrin, filler, a disintegrating agent, an adhesive and a lubricating agent. The pravastatin sodium easily dissolves in water after being subjected to inclusion of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), the stability of the medicine is improved, release of the medicine in vivo is promoted, the absorption is improved, the bioavailability is improved, and the difference between medication individuals is reduced.

The invention relates to the technical field of medicine preparations, in particular to a Mongolian medicine paste for child hyperpyrexia and a preparation method and application method thereof. Mongolian medicine eridun-7 soup is used as a powdery preparation for solving the problems that treatment is influenced due to poor adaptability and difficult application during child hyperpyrexia treatment. The oral powdery preparation is changed into an external use paste, extracts of all medicinal materials are used for replacing raw material medicine, and the treatment effect after use is better. The Mongolian medicine paste for child hyperpyrexia has the advantages that 1, the first-pass effect of the liver and degradation of the medicine in the gastrointestinal tract can be avoided, medicineabsorption is not influenced by gastrointestinal factors, and the individual difference of medicine application is reduced; 2, the medicine can enter the human body at the constant speed for a long time after one-time medicine application, the frequency of medicine application is reduced, and the interval of medicine application is prolonged; 3, the medicine application area is changed, the medicine application dosage is adjusted, and a patient takes the medicine by himself / herself; 4, the Mongolian medicine paste has the sustained or controlled release effect, the medicine can be slowly released at a certain speed, the constant plasma concentration is formed in the skin accordingly, and convenience is provided for prolonging the treatment time of the medicine.

The invention provides a butylphthalide preparation and a preparation method thereof. Specifically, the invention provides the butylphthalide preparation, and oleic acid is used as a solubilizing auxiliary material, so that the oral bioavailability of the butylphthalide preparation is improved, the individual difference is reduced, and the adverse reaction is reduced. The preparation has the advantages of being good in medicine stability, convenient to package, transport and store and the like, the preparation process is simple, and industrial production is easy.

The invention belongs to the field of medicinal preparations, and in particular relates to a dalanthamine hydrobromide dispersible tablet and a preparation method thereof. Due to low bioavailability of dalanthamine hydrobromide in oral absorption and large difference among administration individuals, the dalanthamine hydrobromide dispersible tablet comprises dalanthamine hydrobromide, hydroxypropyl-beta-cyclodextrin, packing, a disintegrating agent, an adhesive and a lubricant. Dalanthamine hydrobromide is easily dissolved in water after being included by hydroxypropyl-beta-cyclodextrin (HP-beta-CD), so that the medicinal stability can be improved, in-vivo release of the medicament can be accelerated, absorption can be improved, bioavailability can be improved, and difference among administration individuals can be reduced.

The invention relates to a carcinogenic mouse model and an establishment method and application thereof, and belongs to the technical field of animal models. The mouse model is obtained by transferring a vector containing a human protooncogene c-Ha-ras (HRAS) gene sequence fragment into C57BL / 6 mouse embryonic stem cells, performing blastocyst injection, transplanting into a receptor mouse and performing screening. According to the mouse model, a stem cell targeting technology is adopted, a transgenic vector for highly expressing human proto-oncogene is established and subjected to fixed-point insertion, the mouse model is obtained through construction, C57BL / 6 stem cells are directly used as a mouse background, a fixed-point insertion model with the pure C57BL / 6 background can be directly obtained without long backcross, and the obtained mouse model is more uniform and better in result consistency.

The invention discloses a skeleton type lovastatin sustained-release micropill and a preparation method thereof, and belongs to the technical field of medicines. The skeleton type lovastatin sustained-release micropill is mainly prepared from the following raw materials in parts by weight: 5 to 25 parts of lovastatin, 0.1 to 5 parts of hydrophilic carrier and adhesive, 10 to 80 parts of a skeleton material, 20 to 60 parts of pore former, 0.2 to 1.5 parts of antioxidant, and 15 to 70 parts of distilled water. The skeleton type lovastatin sustained-release micropill is a sustained-release preparation which is taken orally one time a day, and an in-vitro release test proves that drug release of the micropill can be 12 hours. The skeleton-type lovastatin sustained-release micropill has simple process and stable blood concentration, has the characteristics of safety, high efficiency, low toxicity, convenience in administration and the like, can be used for treating hypercholesterolemia and combined hyperlipidemia, and has prevention and treatment effects to atherosclerosis and coronary heart disease.

The invention belongs to the field of medical preparations, and particularly relates to a rosuvastatin calcium dispersible tablet and a preparation method thereof. Rosuvastatin calcium is low in bioavailability after being orally taken and absorbed, and the individuals for medication have large difference, therefore, the invention provides the rosuvastatin calcium dispersible tablet which comprises rosuvastatin calcium, hydroxypropyl-beta-cyclodextrin, a filler, a disintegrating agent, a binder and a lubricant. Rosuvastatin calcium is easily dissolved into water after being coated by hydroxypropyl-beta-cyclodextrin (HP-beta-CD), the stability of the tablet can be enhanced, the release and absorption of the drug in a human body can be promoted, the bioavailability can be improved, and the difference of the individuals for medication can be reduced.

The invention provides a method for cultivating thick-shelled snails, and specifically relates to the technical field of aquaculture. The present invention comprises the following steps: a. Construction of the snail pond: select a place with sufficient water source and fresh and clean water to build the snail pond, and stack straws by the pool; The snail bait is fed, and after screening, the optimal young snails are obtained; c. Feeding management: feed the optimal young snails until they grow into adult snails with a weight of 22-34g; d. Retaining seeds for reproduction and harvesting: according to 4-5 : Male to female ratio of 1-2 selects adult snails with a body weight of 24-34g and a shell thickness of more than 0.7cm for reserved breeding. The thick-shelled escargot cultivated by the invention has a large body, a thick shell, is convenient for transportation, has a crisp and sweet taste, a high survival rate and stable quality.

The invention belongs to the field of pharmaceutical preparations, and in particular relates to a dispersible tablet of valsartan and a preparation method thereof. Due to the low bioavailability of oral absorption of valsartan, the individual differences in medication are relatively large, for this reason the invention provides a dispersible tablet of valsartan, which contains valsartan, hydroxypropyl-β-cyclodextrin and Fillers, disintegrants, binders, lubricants. Valsartan is easily soluble in water after inclusion with hydroxypropyl-β-cyclodextrin (HP-β-CD), and improves the stability of the drug, promotes the release of the drug in the body, increases absorption, and improves bioavailability , to reduce inter-individual variability.

The invention provides a breeding method for the thick-shelled snail, and specifically relates to the technical field of aquaculture. The present invention includes the following steps: a. construction of snail pond: selecting a place with sufficient water source and fresh and clean water to build snail pond; b. selection and placement of parents: selecting stone snail as male parent and field snail as female parent; c. seedling cultivation : Select individuals with a shell thickness of 60-80mm from the offspring produced by the female parent, and bred according to the male-to-male ratio of 4-5:1 to produce the second offspring; d. In the second generation, dead snails and snails with holes in the tail are eliminated to obtain thick-shelled snails; e. Thick-shelled snails culture: thick-shelled snails are cultured to 8-12 months of age, and the ratio of male to female is 4-5:1 for reservation. , for the reproduction of the next generation. The thick-shelled snails bred by the invention have large body size, thick shell, convenient transportation, crisp, fresh and sweet taste, high survival rate and stable quality.

The invention relates to an anti-parasitic ivermectin transdermal solution used for livestock and a preparation method thereof. The anti-parasitic ivermectin transdermal solution comprises the following components respectively according to parts by volume: 5 to 15 parts of ethyl acetate, 20 to 30 parts of dimethyl sulfoxide, 2 to 6 parts of azone, 1 to 3 parts of isopropanol and 50 to 70 parts ofpropanediol; and the content of ivermectin is 0.3g to 1g in a solution of 100ml, and the finished product is prepared by the processes of dissolving, mixing, filtering and filling. The azone related in the prescription of the invention is a novel skin penetration enhancer, can increase the transdermal absorption of the skin to various medicines of different types, effectively avoids the pass effect of hepar, avoids peak and valley phenomena in the absorption process of the medicine, reduces the toxic or side effect caused by the correlative dosage in the medicine, prolongs the effective effecttime, changes the administration area, effectively regulates the administration dosage and reduces differences among individuals. The invention has the characteristic of simple, convenient and fast use, and is more suitable for the anti-parasitic prevention and treatment of a pasturing area compared with other preparation forms.

The invention discloses a suprachoroidal space pressurized hydrogel balloon device for rhegmatogenous retinal detachment, which consists of a hydrogel balloon, an injection needle and a filler. The hydrogel balloon consists of a balloon main body, The head-side blind-end sheath and the tail-end self-closing valve are formed. When not inflated, the shape is a unilateral blind-tube-like oblate sac. The wall of the blind-end sheath on the head side of the balloon is thicker than the wall of the main body of the balloon, forming a tight wrap around the tip of the injection needle. There is a one-way self-closing diaphragm in the main body of the balloon, and the long diameter of the balloon is divided into multiple compartments. The tail side of the balloon is connected with a hydrogel double self-closing valve, and the inner diameter of the tube can be placed in the suprachoroidal space After the needle core is punctured and the injection needle is withdrawn, the lumen is tightly closed due to the dual effects of the elastic retraction of the tube wall itself and the corresponding peripheral elastic ring, so that the contents of the balloon will not leak out; there is a scale on the injection needle. The length, width, and height of the balloon pressurized crest of the present invention are stable, controllable and adjustable, the absorption time of the balloon wall determines the retention time of the crest, and the difference among individuals is small, which can improve the success rate of the operation.

The invention discloses a method for detecting exogenous compound immunosuppression through secondary TDAR (T cell-dependent antibody response). The method comprises the following steps of (1) injecting T cell-independent antigens into an animal; (2) injecting the same T cell-independent antigens again 15 to 25 days after the injection in the step (1) to excite secondary immune response, and starting to continuously feed exogenous compounds to the animal for 2 to 5 days through the mouth; and (3) after 6-10 days since the step (2) is ended, collecting peripheral blood, separating serum, and detecting a specific antibody of the antigens in the step (1). The method is short in immune response time and high in response degree; the number of the required exogenous compounds is small; furthermore, the method can be applied to early medicine screening.

The invention relates to an antiparasitic closantel sodium transdermal solution for ox and sheep and a preparation method thereof, the composing components of the solution and the parts by weight thereof are respectively that 5-15 parts of ethyl acetate, 20-30 parts of dimethyl sulfoxide, 2-6 parts of azone, 1-3 parts of isopropanol and 50-70 parts of propanediol or ethanol, the content of closantel sodium is 2.5-5 g per 100 ml, and the finished product is formed through dissolving, mixing, filtering and injecting. The azone related in the solution is a novel skin penetration accelerant, can effectively increase the absorption of the skin to various drugs through the skin, effectively prevents the pass effect of hepar, avoids the peak valley phenomenon during the absorbing process of the drugs, reduces the toxic side effect caused by about the drugs and the dosage, prolongs the effective acting time, changes the drug feeding area and effectively regulates the drug feeding dosage, reduces the difference between independent bodies, and has the characteristic of simple, convenient and rapid use. Compared with the other types of preparations, the solution is more suitable for antiparasitic preventive treatment and parasite killing in pasturing areas.

The invention relates to a multi-focus image fusion method and belongs to the field of image processing. An enhanced differential evolution method and an image fusion method of an expansion block selection mechanism are adopted in the multi-focus image fusion process. Compared with a standard differential evolution method, the enhanced differential evolution method is used for judging population after iteration every time according to the sizes of images and interval initial population; one individual is reserved on the premise that all the individuals in the population are the same; the rest individuals are reinitialized and served as a new generation of population together in the corresponding interval by an initialization method of a standard differential evolution algorithm, and local search is enhanced, so that the optimal block size of the image is acquired; in addition, when the fitness of image blocks is equal, extension blocks are selected, and the fused image blocks are acquired by comparing. According to the multi-focus image fusion method, the efficiency of searching the optimal block size in the process of the image fusion is improved, and the computational complexity is reduced; and in addition, the clarity of the whole fused image is fully considered in the process of the image fusion.

The invention provides a method for breeding thick-shell river snails, and particularly relates to the technical field of aquaculture. The method comprises the following steps of: a, building a riversnail pool, specifically, a place with sufficient water source and fresh and clean water quality is selected to build the river snail pool; b, selecting and rearing river snail parents, specifically,a stone snail is chosen as a male parent and a river snail is chosen as a female parent; c, breeding young river snails, specifically, the individual young river snails with the shell thickness of 60-80 mm are selected from a first generation produced by the female parents, and hybridization is carried out according to the ratio of female to male of 4-5: 1 to produce a second generation of the young river snails; d, rearing and screening the young river snails, specifically, dead river snails and the river snails with holes at the tails of the second generation of the young river snails are weeded out to obtain the thick-shell river snails; and e, breeding the thick-shell river snails, specifically, the thick-shell river snails are raised to 8-12 months of age and then the thick-shell river snails for the breeding of a next generation of the river snails are reserved according to the ratio of female to male of 4-5: 1. According to the method, the bred thick-shell river snails have theadvantages of being large in body size, thick in shell, convenient to transport, crisp in mouth feeling, fresh and sweet in taste, high in survival rate and stable in quality; and the breeding processof the method is simple and feasible, the elimination rate is low, the management is convenient, and easy to be popularized.