A kind of rosuvastatin calcium dispersible tablet and preparation method thereof
A technology for rosuvastatin calcium and dispersible tablets, which is applied in the field of rosuvastatin calcium dispersible tablets and their preparation, can solve complex biopharmaceutical properties, low permeability of rosuvastatin calcium, and rosuvastatin calcium. Reduce permeability and other problems to achieve the effect of improving bioavailability and improving bioavailability
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Embodiment 1
[0028]
[0029] Preparation Process:
[0030] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in a proper amount of water to make a saturated aqueous solution. Pass the rosuvastatin calcium through a 120-mesh sieve, and dissolve it in a proper amount of ethanol. The ethanol solution was slowly added to the saturated aqueous solution of hydroxypropyl cyclodextrin, and after all was added, the stirring was continued at room temperature for 3 hours, and most of the ethanol was removed by rotary evaporation at 45°C. Put it into the shallow dish, put it in the freezer compartment of the refrigerator, the pre-freezing time is 12h, the temperature is -50℃, when the temperature of the cold trap in the freeze-drying box reaches -50℃, put in the sample, vacuum, the pressure does not exceed 20Pa, sublimation Dry for 24h to obtain inclusion compound.
[0031] The microcrystalline cellulose is passed through a 100-mesh sieve, and the rosuvastatin calcium hydroxypro...
Embodiment 2
[0034]
[0035]
[0036] Preparation Process:
[0037] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in a proper amount of water to make a saturated aqueous solution. Pass the rosuvastatin calcium through a 120-mesh sieve, and dissolve it in a proper amount of ethanol. The ethanol solution was slowly added to the saturated aqueous solution of hydroxypropyl-β-cyclodextrin, and after all was added, the stirring was continued at room temperature for 4 hours, and most of the ethanol was removed by rotary evaporation at 45°C. Put it into the shallow dish, put it in the freezer compartment of the refrigerator, the pre-freezing time is 12h, the temperature is -50℃, when the temperature of the cold trap in the freeze-drying box reaches -50℃, put in the sample, vacuum, the pressure does not exceed 20Pa, sublimation Dry for 24h to obtain inclusion compound;
[0038] The microcrystalline cellulose is passed through a 100-mesh sieve, and the rosuvastatin calcium...
Embodiment 3
[0041]
[0042]
[0043] Preparation Process:
[0044] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in a proper amount of water to make a saturated aqueous solution. Pass the rosuvastatin calcium through a 120-mesh sieve, and dissolve it in a proper amount of ethanol. The ethanol solution was slowly added to the saturated aqueous solution of hydroxypropyl cyclodextrin, and after all the addition was completed, stirring was continued at room temperature for 2 hours, and most of the ethanol was removed by rotary evaporation at 40°C. Put it into the shallow dish, put it in the freezer compartment of the refrigerator, the pre-freezing time is 12h, the temperature is -50℃, when the temperature of the cold trap in the freeze-drying box reaches -50℃, put in the sample, vacuum, the pressure does not exceed 20Pa, sublimation Dry for 24h to obtain inclusion compound;
[0045] The microcrystalline cellulose is passed through a 100-mesh sieve, and the rosuvasta...
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