A kind of rosuvastatin calcium dispersible tablet and preparation method thereof

A technology for rosuvastatin calcium and dispersible tablets, which is applied in the field of rosuvastatin calcium dispersible tablets and their preparation, can solve complex biopharmaceutical properties, low permeability of rosuvastatin calcium, and rosuvastatin calcium. Reduce permeability and other problems to achieve the effect of improving bioavailability and improving bioavailability
CN103860498BInactive Publication Date: 2016-05-04杨冬梅
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
杨冬梅
Publication Date
2016-05-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of medical preparations, and particularly relates to a rosuvastatin calcium dispersible tablet and a preparation method thereof. Rosuvastatin calcium is low in bioavailability after being orally taken and absorbed, and the individuals for medication have large difference, therefore, the invention provides the rosuvastatin calcium dispersible tablet which comprises rosuvastatin calcium, hydroxypropyl-beta-cyclodextrin, a filler, a disintegrating agent, a binder and a lubricant. Rosuvastatin calcium is easily dissolved into water after being coated by hydroxypropyl-beta-cyclodextrin (HP-beta-CD), the stability of the tablet can be enhanced, the release and absorption of the drug in a human body can be promoted, the bioavailability can be improved, and the difference of the individuals for medication can be reduced.
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Description

Invention field

[0001] The invention relates to the field of chemical pharmacy, in particular to a rosuvastatin calcium dispersible tablet and a preparation method thereof. Background of the invention

[0002] Cardiovascular disease is one of the most common and serious diseases that endanger human health (especially middle-aged and elderly people). Dyslipidemia is an important risk factor for atherosclerosis, coronary heart disease and other cardiovascular and cerebrovascular diseases. Lipid-lowering drugs can reduce these The incidence and mortality of diseases have a positive and profound impact on the prevention and treatment of cardiovascular diseases. With the advent of the aging society, the proportion of cardiovascular diseases in the elderly caused by hyperlipidemia and other diseases is increasing year by year, which seriously threatens people's lives. Therefore, searching for effective, safe and reliable lipid-lowering drugs has always been a long-term and quite popul...

Claims

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