Rosuvastatin calcium dispersible tablet and preparation method thereof
A technology of rosuvastatin calcium and dispersible tablets, which is applied in the field of rosuvastatin calcium dispersible tablets and its preparation, can solve the problem of low permeability of rosuvastatin calcium, complex biopharmaceutical properties, rosuvastatin calcium Reduced permeability and other issues, to achieve the effect of improving bioavailability and improving bioavailability
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Embodiment 1
[0028]
[0029] Preparation Process:
[0030] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in an appropriate amount of water to make a saturated aqueous solution. Pass rosuvastatin calcium through a 120-mesh sieve and dissolve it in an appropriate amount of ethanol. The ethanol solution was slowly added to the saturated aqueous solution of hydroxypropyl cyclodextrin, and after all the addition was completed, stirring was continued at room temperature for 3 hours, and most of the ethanol was removed by rotary evaporation at 45°C. Put it into a shallow tray and put it in the freezer of the refrigerator. The pre-freezing time is 12 hours and the temperature is -50°C. When the temperature of the cold trap in the freeze-drying box reaches -50°C, put the sample in, vacuumize, and the pressure does not exceed 20Pa. Sublimation After drying for 24 hours, the clathrate was obtained.
[0031] Microcrystalline cellulose is passed through a 100-mesh sie...
Embodiment 2
[0034]
[0035]
[0036] Preparation Process:
[0037] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in an appropriate amount of water to make a saturated aqueous solution. Pass rosuvastatin calcium through a 120-mesh sieve and dissolve it in an appropriate amount of ethanol. The ethanol solution was slowly added to the saturated aqueous solution of hydroxypropyl-β-cyclodextrin, and after all the addition was completed, stirring was continued at room temperature for 4 hours, and most of the ethanol was removed by rotary evaporation at 45°C. Put it into a shallow tray and put it in the freezer of the refrigerator. The pre-freezing time is 12 hours and the temperature is -50°C. When the temperature of the cold trap in the freeze-drying box reaches -50°C, put the sample in, vacuumize, and the pressure does not exceed 20Pa. Sublimation Dry for 24 hours to obtain clathrate;
[0038] Microcrystalline cellulose is passed through a 100-mesh sieve,...
Embodiment 3
[0041]
[0042]
[0043] Preparation Process:
[0044] Take the prescription amount of hydroxypropyl-β-cyclodextrin and dissolve it in an appropriate amount of water to make a saturated aqueous solution. Pass rosuvastatin calcium through a 120-mesh sieve and dissolve it in an appropriate amount of ethanol. The ethanol solution was slowly added into the saturated aqueous solution of hydroxypropyl cyclodextrin, and after all the addition was completed, stirring was continued at room temperature for 2 hours, and most of the ethanol was removed by rotary evaporation at 40°C. Put it into a shallow tray and put it in the freezer of the refrigerator. The pre-freezing time is 12 hours and the temperature is -50°C. When the temperature of the cold trap in the freeze-drying box reaches -50°C, put the sample in, vacuumize, and the pressure does not exceed 20Pa. Sublimation Dry for 24 hours to obtain clathrate;
[0045] Microcrystalline cellulose passed through a 100-mesh sieve, mi...
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