A kind of dispersible tablet of valsartan and preparation method thereof
A technology of dispersible tablet and valsartan, which is applied in the field of valsartan dispersible tablet and its preparation, can solve the problems of low valsartan permeability, complexity, and reduced valsartan permeability, so as to improve bioavailability , The effect of improving bioavailability
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Embodiment 1
[0037] Valsartan 20g
[0038] Hydroxypropyl-β-cyclodextrin 60g
[0039]Mannitol 20g
[0040] Compressible starch 10g
[0041] Microcrystalline Cellulose 10g
[0042] Croscarmellose Sodium 5g
[0043] 2% polyvinylpyrrolidone aqueous solution 100g
[0045] Preparation Process:
[0046] Take the prescribed amount of hydroxypropyl-β-cyclodextrin and dissolve it in an appropriate amount of water to make a saturated aqueous solution. Pass valsartan through a 120-mesh sieve and dissolve it in an appropriate amount of ethanol. Under magnetic stirring, slowly dissolve the ethanol solution of valsartan Add the saturated aqueous solution of hydroxypropyl-β-cyclodextrin, continue to stir at room temperature for 3 hours after all the addition is complete, and remove most of the ethanol by rotary evaporation at 45°C. Put it into a shallow tray and put it in the freezer of the refrigerator. The pre-freezing time is 12 hours and the temperature is -50°C. ...
Embodiment 2-8
[0049] Embodiment 2-8 valsartan dispersible tablet
[0050] For the convenience of narration, the prescription of embodiment 2-8 valsartan dispersible tablet is shown in Table 1. In the table, "Example 2" indicates the prescription of Example 2, and "Example 3"-"Example 8" respectively indicate "Prescription of Example 3"-"Prescription of Example 8".
[0051] Table 1 embodiment 2-8 valsartan dispersible tablet prescription
[0052]
[0053] The preparation process of the valsartan dispersible tablet of embodiment 2: take prescription quantity hydroxypropyl-beta-cyclodextrin appropriate amount and dissolve in appropriate amount of water to make saturated aqueous solution, valsartan crosses 120 mesh sieves, dissolves in appropriate amount of ethanol, in Under magnetic stirring, the ethanol solution of valsartan was slowly added to the saturated aqueous solution of hydroxypropyl-β-cyclodextrin. After all the addition was completed, stirring was continued at room temperature f...
Embodiment 9
[0061] Embodiment 9 Relative bioavailability research of valsartan dispersible tablet
[0062] 1 Materials and methods
[0063] 1.1 Drugs and reagents
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