Heparolysate injection pharmaceutical composition
A liver hydrolysis peptide and injection technology, applied in the field of biochemical pharmacy, can solve the problems of limited therapeutic effect, reduce protein decomposition, etc., achieve the effect of promoting vitality stimulation index, obvious curative effect, and promoting the growth of human liver cells
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Embodiment 1
[0048] 1. Hepatic hydrolyzed peptide solution
[0049]Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.
[0050] 2. Add 5g of vitamin C to 1000ml of the hepatic hydrolyzed peptide solution obtained above, add 30ml of potassium magnesium aspartate injection, add 15g of polyethylene glycol 200, an...
Embodiment 2
[0052] 1. Hepatic hydrolyzed peptide solution
[0053] Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.
[0054] 2. Add 1000ml of the liver hydrolyzed peptide solution obtained above, add 2g of vitamin C, add 20ml of potassium magnesium aspartate injection, add 10g of polyethylene glycol 200, a...
Embodiment 3
[0056] 1. Hepatic hydrolyzed peptide solution
[0057] Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.
[0058] 2. Add 1000ml of liver hydrolyzed peptide solution obtained above, add 5g of vitamin C, add 25ml of potassium magnesium aspartate injection, add 20g of polyethylene glycol 200, after...
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