Heparolysate injection pharmaceutical composition

A liver hydrolysis peptide and injection technology, applied in the field of biochemical pharmacy, can solve the problems of limited therapeutic effect, reduce protein decomposition, etc., achieve the effect of promoting vitality stimulation index, obvious curative effect, and promoting the growth of human liver cells

Inactive Publication Date: 2011-11-02
长春白求恩制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hepatic hydrolyzed peptide can promote protein synthesis, reduce protein decomposition, promote the proliferation and regeneration of normal liver cells, have a good protective effect on liver cell damage induced by carbon tetrachloride, reduce alanine aminotransferase, and promote the recovery of diseased tissues; but the The therapeutic effect o

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Hepatic hydrolyzed peptide solution

[0049]Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.

[0050] 2. Add 5g of vitamin C to 1000ml of the hepatic hydrolyzed peptide solution obtained above, add 30ml of potassium magnesium aspartate injection, add 15g of polyethylene glycol 200, an...

Embodiment 2

[0052] 1. Hepatic hydrolyzed peptide solution

[0053] Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.

[0054] 2. Add 1000ml of the liver hydrolyzed peptide solution obtained above, add 2g of vitamin C, add 20ml of potassium magnesium aspartate injection, add 10g of polyethylene glycol 200, a...

Embodiment 3

[0056] 1. Hepatic hydrolyzed peptide solution

[0057] Bovine liver, after removing the connective tissue, mixes it with water for injection at a weight ratio of 0.85:1, homogenizes it with a high-speed tissue grinder, raises the temperature to 37~40°C, adjusts the pH value to 2.0~2.5 with HCL, press Add pepsin at 3g / liter, hydrolyze for 10 hours, adjust the pH value of the hydrolyzate to 6.2~6.4 with NaOH, add 1g / liter diatomaceous earth, heat at 90°C for 30 minutes, filter with a small plate and frame filter press, use 0.45μm Microporous membrane filtration, 8000 molecular weight ultrafiltration membrane ultrafiltration to obtain hepatic hydrolyzed peptide solution, measure the peptide content, add water for injection to adjust the peptide concentration of the solution to 9.2~12.2mg / ml.

[0058] 2. Add 1000ml of liver hydrolyzed peptide solution obtained above, add 5g of vitamin C, add 25ml of potassium magnesium aspartate injection, add 20g of polyethylene glycol 200, after...

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PUM

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Abstract

The invention discloses a Heparolysate injection pharmaceutical composition. The pharmaceutical composition is prepared from Heparolysate, vitamin C, potassium aspartate and magnesium aspartatse injection and polyethylene glycol 200. Low vitality stimulation indexes and limited treatment effects of the Heparolysate injection are overcome. The invention also discloses a preparation method of the pharmaceutical. The preparation method which has the characteristic of simple technology is suitable for industrialization production.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hepatitis and liver cirrhosis, and further provides a pharmaceutical composition for hepatic hydrolysis peptide injection, which belongs to the technical field of biochemical pharmacy. Background technique [0002] The existing "hepatic hydrolysis peptide injection" is a prescription drug in my country, intramuscular injection, used for adjuvant treatment of chronic hepatitis, liver cirrhosis and other diseases. , Nucleic acid, amino acid substances sterile aqueous solution. Hepatic hydrolyzed peptide can promote protein synthesis, reduce protein decomposition, promote the proliferation and regeneration of normal liver cells, have a good protective effect on liver cell damage induced by carbon tetrachloride, reduce alanine aminotransferase, and promote the recovery of diseased tissues; but the The therapeutic effect of drugs on hepatitis and liver cirrhosis is still very limited. Accord...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K47/34C12P21/06A61P1/16A61K31/198A61K31/375
Inventor 王巍
Owner 长春白求恩制药有限公司
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