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Potassium aspartate compound electrolyte injection and preparation method thereof

A technology of potassium aspartate and compound electrolyte, which is applied in the field of potassium aspartate compound electrolyte injection and its preparation, which can solve problems such as slow metabolism, assist liver function, protect liver function, and reduce dilution acidosis The effect of the risk

Inactive Publication Date: 2018-09-28
LIAONING YAOLIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second-generation electrolyte infusion is to supplement a variety of electrolytes, represented by Ringer's solution-Lactated Ringer's solution, which is characterized by reducing the amount of sodium chloride, adding sodium lactate and potassium ions and calcium ions, in addition to meeting the basic physiological needs, it also meets potassium. The important electrolyte requirements of calcium, lactic acid, make its composition closer to the extracellular fluid, but when the tissue is hypoxic, the metabolic conversion is inhibited, resulting in the accumulation of lactate and the deterioration of acidosis. In addition, sodium lactate is metabolized in the liver, and the metabolism is slow. When the infusion volume is large or the patient is accompanied by liver dysfunction, it can lead to the accumulation of lactate and cause acidosis

Method used

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  • Potassium aspartate compound electrolyte injection and preparation method thereof
  • Potassium aspartate compound electrolyte injection and preparation method thereof
  • Potassium aspartate compound electrolyte injection and preparation method thereof

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preparation example Construction

[0048] The preparation method of potassium aspartate compound electrolyte injection of the present invention comprises the following steps:

[0049] Put sodium chloride, calcium chloride, potassium aspartate, magnesium chloride, sodium acetate, and L-malic acid in the concentrated preparation tank according to a predetermined ratio, and pump 65-85% of the total amount of water for injection into 65-85% ℃ of water for injection, control the temperature of the concentrated preparation tank between 40°C and 70°C, and circulate for 15min-45min; add 10% sodium hydroxide solution into the concentrated preparation tank, take a sample to test the pH, and adjust the pH to 5- 7; add 0.1% activated carbon for needles to the concentrated preparation tank, control the temperature of the concentrated preparation tank between 40-70°C, and circulate for 15-45min; filter and remove it with a titanium rod filter and a 0.45um fine filter element in turn Activated carbon, and pump the filtrate in...

Embodiment 1

[0052]

[0053]

[0054] Preparation method: Weigh sodium chloride, calcium chloride, potassium aspartate, magnesium chloride, sodium acetate, and L-malic acid according to the prescription, put them in a concentrated preparation tank, dissolve them in 500ml of 65°C water for injection, and stir for 45 minutes. Control the temperature of the concentrated preparation tank at 60°C until it dissolves completely; add 10% sodium hydroxide solution, take a sample to test the pH, and adjust the pH to 5-7; add 2.5g of activated carbon for needles, stir at a constant temperature of 60°C for 20 minutes, and use Titanium rod filter and 0.45um fine filter element filter to remove activated carbon, and pump the filtrate into the dilute tank and cool down to room temperature; dilute to 1000ml with water for injection, stir for 40min; add 10% sodium hydroxide solution, take a sample to test the pH , and adjust the pH to between 5-7; filter through a 0.22um filter element, pump the filtr...

Embodiment 2

[0056]

[0057] Preparation method: Weigh sodium chloride, calcium chloride, potassium aspartate, magnesium chloride, sodium acetate, and L-malic acid according to the prescription, put them in a concentrated preparation tank, dissolve them in 200ml of 85°C water for injection, and stir for 15 minutes to control The temperature of the concentrated preparation tank is at 40°C until it is completely dissolved; add 5g of activated carbon for needles, stir at a constant temperature of 40°C for 45 minutes, filter and remove the activated carbon with a titanium rod filter and a 0.45um fine filter element, and pump the filtrate into the thinner preparation tank, down to Room temperature; dilute to 1000ml with water for injection at room temperature, stir for 25 minutes; filter through a 0.22um filter element, pump the filtrate to the filling line, fill it into a 500ml infusion bag, and then sterilize in a water bath at 115°C for 30 minutes; Demen Potassium aspartate compound electr...

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Abstract

The invention provides a potassium aspartate compound electrolyte injection and a preparation method thereof. The injection is 1000 mL in weight and comprises, by weight, 6.6-6.9g of sodium chloride;0.35-0.38g of calcium chloride; 0.65-6.9g of potassium aspartate, 0.18-0.22g of magnesium chloride; 3.1-3.4g of sodium acetate; 0.65-0.69g L-malic acid, 0.15-0.25g of sodium hydroxide and the balancewater. The aspartate is adopted in the anion of the injection, the chloride ion concentration can be further reduced, the ion composition is closer to the ratio of plasma electrolyte, and the plasma composition can be better matched. The acetate and malic acid are used as precursors of bicarbonate, balanced alkali residue is achieved, the risk of diluted acidosis is reduced; the liver burden is not aggravated, and the malic acid and aspartate can also play an auxiliary role in protecting liver function.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a potassium aspartate compound electrolyte injection and a preparation method thereof. Background technique [0002] Infusion refers to a large dose of injection that is infused into the body by intravenous infusion. The types of infusion include electrolyte infusion, nutrient infusion, and colloid infusion. [0003] The development history of electrolyte infusion: the first generation of electrolyte infusion is a single electrolyte, represented by normal saline, which can meet the basic physiological needs of sodium and chloride. Because of the high concentration of chloride ions, it may cause metabolic acidosis when infused in large quantities. The second-generation electrolyte infusion is to supplement a variety of electrolytes, represented by Ringer's solution-Lactated Ringer's solution, which is characterized by reducing the amount of sodium chloride, adding so...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61K9/08A61P7/08A61P1/16A61K31/198A61K33/06A61K31/19A61K31/194A61K33/00
CPCA61K9/0019A61K9/08A61K31/19A61K31/194A61K31/198A61K33/00A61K33/06A61K33/14A61P1/16A61P7/08A61K2300/00
Inventor 于航陶闰红毕洪书
Owner LIAONING YAOLIAN PHARMA
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