Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Potassium aspartate tablet and preparation method thereof

A technology for potassium aspartate tablets and potassium aspartate tablets is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. Poor moisture absorption and sticking of materials, etc., to achieve the effect of reducing hygroscopicity, reducing hygroscopicity and improving slivers

Active Publication Date: 2014-10-01
LIAONING YAOLIAN PHARMA
View PDF2 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The commonly used specification of potassium aspartate tablets is 0.3g, and the drug loading capacity is relatively large, but the raw material of potassium aspartate has strong hygroscopicity, and its compressibility is also poor, and the material is prone to moisture absorption during the tableting process Sticky punch, tablet split problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Potassium aspartate tablet and preparation method thereof
  • Potassium aspartate tablet and preparation method thereof
  • Potassium aspartate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Prescription composition:

[0038]

[0039] Preparation:

[0040] (1) Binder configuration: weigh 30g of stearic acid, add it to 210g of ethanol (95%), heat to dissolve the stearic acid, and use it as a binder;

[0041] (2) Granulation: Weigh potassium aspartate and microcrystalline cellulose and mix evenly, add binder, stir evenly, and granulate with 18-mesh nylon screen; dry in a hot air circulation oven at 60°C for 4 hours; granules, add talcum powder and mix well;

[0042] (3) Tablet pressing: Use a rotary tablet press machine to press the tablet, the weight of the tablet is about 0.5g;

[0043] (4) Coating: Opadry (trade name, manufactured by Colorcon) was used for coating. Based on the plain tablet, the weight of the stomach-soluble moisture-proof coating increased by 3%.

[0044] In this example:

[0045] (1) The dosage of stearic acid in the tablet core formulation is 6%. Stearic acid is a hydrophobic material. After mixing with potassium aspartate, the s...

Embodiment 2

[0051] According to the method described in embodiment 1, utilize following prescription composition to prepare potassium aspartate tablet. Results Based on the plain tablet, the weight gain of the stomach-soluble moisture-proof coating was about 3%.

[0052] Prescription composition:

[0053]

Embodiment 3

[0055] According to the method described in embodiment 1, utilize following prescription composition to prepare potassium aspartate tablet. Results Based on the plain tablet, the weight gain of the stomach-soluble moisture-proof coating was about 3%.

[0056] Prescription composition:

[0057]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a potassium aspartate tablet and a preparation method thereof. The potassium aspartate tablet comprises a tablet core and a coating, wherein the tablet core contains potassium aspartate and pharmaceutically acceptable adjuvant. The adjuvant comprises waxy adjuvant and other adjuvant. The tablet comprises, by weight, 30 to 90% of potassium aspartate and 0.5 to 20% of the waxy adjuvant, wherein the waxy adjuvant is one or more selected from the group consisting of glyceryl stearate, glyceryl monostearate, stearic acid, Chinese wax, beeswax and octadecanol. Compared with a potassium aspartate tablet without the above-mentioned adjuvant, the potassium aspartate tablet provided by the invention has the following advantages: in the preparation process of the potassium aspartate tablet, material hygroscopicity is obviously reduced, compressibility is obviously improved, stability of the finished tablet is enhanced, and preparation difficulty and production cost of the potassium aspartate tablet are decreased.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a potassium aspartate tablet and a preparation method thereof. Background technique [0002] Potassium L-aspartate is a potassium supplement with the molecular formula C 4 h 6 KNO 4 1 / 2H 2 O, the structural formula is: [0003] [0004] Potassium is the main cation in cells, which is necessary for cell survival and has various physiological functions. 98% of the potassium is present in the cells, and the extracellular fluid contains only 2%. Potassium in the extracellular fluid mainly exists in the ion state. In addition to the ion state in the intracellular fluid, part of the potassium is combined with protein, and the other part is combined with sugar and phosphate. Potassium plays an important role in cell metabolism, maintenance of intracellular osmotic pressure, maintenance of intracellular acid-base balance, transmission of nerve impulses, mus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/198A61K47/44A61K47/14A61K47/12A61P3/12
Inventor 于航
Owner LIAONING YAOLIAN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com