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Preparation method of potassium aspartate crude drug

A technology of potassium aspartate and aspartic acid is applied in the preparation of organic compounds, chemical instruments and methods, cyanide reaction preparation, etc., and can solve the problems of low yield, unsafe industrial production conditions, poor product stability, etc. problem, to achieve the effect of simple process, easy industrial production and stable quality

Inactive Publication Date: 2014-03-26
沈阳药联科技创新有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many reports on the process research of potassium aspartate raw materials, but there are various problems such as low yield, poor product stability, and unsafe industrial production conditions.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Name of raw material Prescription amount aspartic acid 133.10kg Potassium hydroxide 56.11kg medicinal charcoal 230g purified water 130L

[0052] Step (a) Add the prescribed amount of purified water into the liquid mixing tank, and add the weighed potassium hydroxide under stirring. After it is completely dissolved, add aspartic acid in batches while stirring, and stir to react. After all the reactions, the solution should be clarify;

[0053] Step (b) Take about 50ml of the reaction solution, cool it to room temperature, and check that the pH value should be between 6.5 and 7.0. If it deviates, you can adjust it with an appropriate amount of potassium hydroxide or aspartic acid;

[0054] Step (c) Wet the prescribed amount of medicinal charcoal with an appropriate amount of purified water, add it into the liquid mixing tank through the feeding hole, record the temperature of the liquid medicine, and stir for 30 minutes;

[0055]...

Embodiment 2

[0059] Name of raw material Prescription amount aspartic acid 133.10kg Potassium hydroxide 56.11kg medicinal charcoal 250g purified water 150L

[0060]Step (a) Add the prescribed amount of purified water into the liquid mixing tank, and add the weighed potassium hydroxide under stirring. After it is completely dissolved, add aspartic acid in batches while stirring, and stir to react. After all the reactions, the solution should be clarify;

[0061] Step (b) Take about 50ml of the reaction solution, cool it to room temperature, and check the pH value should be between 5.8 and 6.5. If it deviates, it can be adjusted with an appropriate amount of potassium hydroxide or aspartic acid;

[0062] Step (c) Wet the prescribed amount of medicinal charcoal with an appropriate amount of purified water, add it to the liquid mixing tank through the feeding hole, record the temperature of the liquid medicine, and stir for 25 minutes;

[0063] Step (...

Embodiment 3

[0066] Name of raw material Prescription amount aspartic acid 133.10kg potassium carbonate 69.8kg medicinal charcoal 240g purified water 130L

[0067] Step (a) Add the prescribed amount of purified water into the liquid mixing tank, and add the weighed potassium carbonate while stirring. After it is completely dissolved, add aspartic acid in batches while stirring, and stir to react. After all the reactions, the solution should be clear ;

[0068] Step (b) Take about 50ml of the reaction solution, cool it to room temperature, and check the pH value should be between 6.5 and 8.0, if it deviates, it can be adjusted with an appropriate amount of potassium carbonate or aspartic acid;

[0069] Step (c) Wet the prescribed amount of medicinal charcoal with an appropriate amount of purified water, add it into the liquid mixing tank through the feeding hole, record the temperature of the liquid medicine, and stir for 20 minutes;

[0070] Step ...

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Abstract

The invention provides a preparation method of a potassium aspartate crude drug. The preparation method specifically comprises the following steps: (a), adding proper amount of purified water into a liquor preparation tank, adding a potassium salt under stirring, adding aspartic acid in a fractional manner while stirring after all potassium salt is dissolved, and reacting under stirring; (b), detecting that a pH value is between 5.8-8.2, and regulating by using proper amount of the potassium salt or aspartic acid if the detected value deviates from 5.8-8.2; (c), adding medicinal charcoal and stirring for 20 minutes-30 minutes; (d), enabling medical liquor to pass through a decarburization filter, filtering by a 0.45-mu m filter, monitoring and recording that pressure of the 0.45-mu m filter is between a range of 0.15 MPa-0.2 MPa, adding the purified water into the liquor preparation tank after the medical liquor is filtered out, feeding filtrate into a buffer tank by once to twice, and clarifying the filtrate; (e), spray-drying, discharging and sub-packaging.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, and provides a method for preparing a chemical raw material drug, in particular a method for preparing potassium aspartate. Background technique [0002] Aspartate is the precursor of oxaloacetate in the human body and plays an important role in the Krebs cycle. At the same time, it also participates in the ornithine cycle, promotes the metabolism of ammonia and carbon dioxide, and makes it generate urea, thereby reducing the content of ammonia and carbon dioxide in the blood. Aspartic acid has a strong affinity with cells and can be used as a carrier of potassium ions, allowing potassium ions to return to cells and maintain their normal functions. Magnesium ions are indispensable substances for the formation of glycogen and high-energy phosphates, which can enhance the therapeutic effect of potassium aspartate. Therefore, various pharmaceutical preparations such as potassium magnesium aspart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/24C07C227/18C07C227/40
Inventor 于航
Owner 沈阳药联科技创新有限公司
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