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Compound potassium aspartate-glucose injection and preparation method thereof

A technology of compound potassium aspartate and glucose injection, which can be used in blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., can solve problems such as blood sugar rise, achieve the elimination of jaundice symptoms, reduce the content, and avoid high-chlorine metabolism Effects of acidosis

Inactive Publication Date: 2017-01-11
LIAONING YAOLIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glucose provides calories, but rapid infusion of large amounts of sugar-containing electrolyte solutions can lead to markedly elevated blood glucose

Method used

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  • Compound potassium aspartate-glucose injection and preparation method thereof
  • Compound potassium aspartate-glucose injection and preparation method thereof
  • Compound potassium aspartate-glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: Preparation of compound potassium aspartate glucose injection 1000ml:

[0052] Preparation prescription:

[0053] Potassium aspartate 0.725g Magnesium Aspartate 0.325g calcium aspartate 0.456g Sodium chloride 6.372g Sodium acetate 2.052g sodium citrate 0.588g glucose 10g Add water for injection to 1000ml

[0054] Preparation:

[0055] A, take potassium aspartate, calcium aspartate, magnesium aspartate, sodium chloride, sodium acetate, sodium citrate and glucose by recipe quantity;

[0056] B. Add an appropriate amount of water for injection (about 70% of the total volume of water for injection) to fully dissolve, and adjust the pH value to 4.0;

[0057] C. Add activated carbon for injection with a solution volume of 0.1% (w / v), keep warm at 60°C for 30 minutes, filter and decarbonize, and add water for injection to the full amount;

[0058] D. After passing the test of the intermediate, the medicin...

Embodiment 2

[0059] Embodiment 2: Preparation of compound potassium aspartate glucose injection 1000ml:

[0060] Preparation prescription:

[0061] Potassium aspartate 0.685g Magnesium Aspartate 0.288g calcium aspartate 0.46g Sodium chloride 6.425g Sodium acetate 2.125g sodium citrate 0.575g glucose 10g Add water for injection to 1000ml

[0062] Preparation:

[0063] A, take potassium aspartate, calcium aspartate, magnesium aspartate, sodium chloride, sodium acetate, sodium citrate and glucose by recipe quantity;

[0064] B. Add an appropriate amount of water for injection (about 60% of the total volume of water for injection) to fully dissolve, and adjust the pH value to 4.6;

[0065] C. Add activated carbon for needles with a solution volume of 0.1% (w / v), keep warm at 70°C for 30 minutes, filter and decarbonize, and add water for injection to the full amount;

[0066] D. After passing the test of the intermediate, the medicinal ...

Embodiment 3

[0067] Embodiment 3: Preparation of compound potassium aspartate glucose injection 1000ml:

[0068] Preparation prescription:

[0069] Potassium aspartate 0.72g Magnesium Aspartate 0.325g calcium aspartate 0.456g Sodium chloride 6.375g Sodium acetate 2.125g sodium citrate 0.575g glucose 10g Add water for injection to 1000ml

[0070] Preparation:

[0071] A, take potassium aspartate, calcium aspartate, magnesium aspartate, sodium chloride, sodium acetate, sodium citrate and glucose by recipe quantity;

[0072] B. Add an appropriate amount of water for injection (about 80% of the total volume of water for injection) to fully dissolve, and adjust the pH value to 5.6;

[0073] C. Add activated carbon for injection with a solution volume of 0.1% (w / v), keep warm at 80°C for 20 minutes, filter and decarbonize, and add water for injection to the full amount;

[0074] D. After passing the test of the intermediate, the medicina...

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Abstract

The invention relates to the technical field of chemical drugs and especially relates to a compound potassium aspartate-glucose injection prepared from potassium aspartate, calcium aspartate, magnesium aspartate, sodium chloride, sodium acetate, sodium citrate and glucose and a preparation method thereof. The pH, osmotic pressure and all particle mole concentrations of the compound potassium aspartate-glucose injection are similar to those of the human extracellular fluid so that the compound potassium aspartate-glucose injection is called as a potassium aspartate equilibrium liquid. The compound potassium aspartate-glucose injection can be used for treating circulation blood amount reduction-caused shock and operations and injury, burn and profuse bleeding-caused tissue fluid reduction, supplying and adjusting an extracellular liquid and correcting metabolic acidosis, can be used as a crystal-type blood volume expander, can replace a part of blood transfusion, realizes effective tissue perfusion, keeps cycling stability, supplies electrolytes, improves low blood potassium and low blood sodium in shock and prevents and corrects acidosis.

Description

technical field [0001] The invention relates to the field of chemical medicines, in particular to a compound made from potassium aspartate, calcium aspartate, magnesium aspartate, sodium chloride, sodium acetate, sodium citrate and glucose Potassium aspartate glucose injection and preparation method thereof. Background technique [0002] Disorders of water and electrolyte metabolism are very common in clinical practice. Diseases of many organ systems, some systemic pathological processes, such as liver cirrhosis, diabetes, pulmonary heart disease, burns and post-operation, etc., can cause or be accompanied by water and electrolyte metabolism disorders; some changes in the external environment, some Iatrogenic factors such as improper use of drugs can also often lead to disturbance of water and electrolyte metabolism. If it is not corrected in time, the disturbance of water and electrolyte metabolism itself can cause corresponding obstacles to the physiological functions of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K9/08A61P3/12A61P7/08A61K31/7004A61K31/198A61K31/194
Inventor 于航毕洪书
Owner LIAONING YAOLIAN PHARMA
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