The invention discloses a disposable locking type pressure precise filtering closed infusion set belonging to the technical field of medical appliances. The invention adopts the technical scheme as follows: the disposable locking type pressure precise filtering closed infusion set consists of a disposable locking type precise filtering infusion set and an air-storing bag, wherein the disposable locking type precise filtering infusion set comprises a bottle plug puncture unit projecting jacket, a bottle plug puncture unit, a burette, an injection piece, a dropping funnel, a liquid medicine precise filter, a pipeline, a flow rate adjustor, an outer conical joint, an outer conical joint protecting jacket, a locking type outer conical joint and a floating ball; and the air-storing bag comprises a bag body, a pipeline, a flow rate adjustor, a locking type inner conical joint, an inner conical joint protecting plug and an air precise filter. The disposable locking type pressure precise filtering closed infusion set can realize the locking type connection of the air-storing bag and the disposable locking type precise filtering infusion set and adopts high-pressure clean air in the air-storing bag as the power for infusing the liquid medicine, in addition, the liquid medicine is precisely filtered, and fully closed infusion can be performed quickly with controllable flow rate of the liquid medicine. The invention can avoid air pollution in the infusion process, can prevent bacteria, virus and dust from entering the human body, prevent infusion reaction and phlebitis from occurring and prevent air embolism from generating caused by negligence of personnel to endanger the life.