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Aspartic vitamin eye drops and preparation method thereof

A technology of compound aspartame and vitamine eye drops, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the complex composition of compound aspartame and vitamine eye drops and other problems, to achieve the effect of stable content, optimized preparation process and high yield

Active Publication Date: 2008-02-27
江西闪亮制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the complex drug composition of the compound aspart and Vigan eye drops, there are 6 kinds of chemical drugs in total, how to ensure that the eye drops will not be turbid, deteriorated and solution state in a large temperature range or a long storage time Uniformity and stability is also a problem that needs to be seriously solved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 【prescription】

[0024] Aspartic Acid 7.8g

[0025] Vitamin B 6 0.5 grams

[0026] Dipotassium Glycyrrhizinate 1.0g

[0027] Naphazoline Hydrochloride 0.03g

[0028] Neostigmine Methosulfate 0.05g

[0029] Chlorpheniramine Maleate 0.1g

[0030] Polysorbate 80 1.0 g

[0031] Sodium chloride 7.0 g

[0032] Menthol 0.1g

[0033] Benzalkonium Chloride 0.1g

[0034] 1 mol / L sodium hydroxide solution Appropriate amount

[0035] Add water for injection to 1000ml

[0036]

[0037] Makes 1000ml

[0038] 【Method】

[0039] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0040] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added to ...

Embodiment 2

[0044] 【prescription】

[0045] Aspartic Acid 7.8g

[0046] Vitamin B 6 0.5 grams

[0047] Dipotassium Glycyrrhizinate 1.0g

[0048] Naphazoline Hydrochloride 0.03g

[0049] Neostigmine Methosulfate 0.05g

[0050] Chlorpheniramine Maleate 0.1g

[0051] Polysorbate 80 0.5 g

[0052] Sodium chloride 8.0 g

[0053] Menthol 0.05g

[0054] Benzalkonium Chloride 0.1g

[0055] 1 mol / L sodium hydroxide solution Appropriate amount

[0056] Add water for injection to 1000ml

[0057]

[0058] Makes 1000ml

[0059] 【Method】

[0060] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0061] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added...

Embodiment 3

[0065] 【prescription】

[0066] Aspartic Acid 7.8g

[0067] Vitamin B 6 0.5 grams

[0068] Dipotassium Glycyrrhizinate 1.0g

[0069] Naphazoline Hydrochloride 0.03g

[0070] Neostigmine Methosulfate 0.05g

[0071] Chlorpheniramine Maleate 0.1g

[0072] Polysorbate 80 1.0 g

[0073] Sodium chloride 5.0 g

[0074] Menthol 0.2g

[0075] Benzalkonium Chloride 0.1g

[0076] 1 mol / L sodium hydroxide solution Appropriate amount

[0077] Add water for injection to 1000ml

[0078]

[0079] Makes 1000ml

[0080] 【Method】

[0081] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0082] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added t...

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PUM

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Abstract

The invention discloses a compound asparticitin gutta and making method, which comprises the following parts: aspartic acid, vitamin B6, glycyrrhizin dipotassium, naphazoline hydrochloride, neostigmine methylsulfate, maleic chlorobenzenenamin, polysorbate 80, sodium chloride, menthol, benzachloridamine, sodium hydroxide solution and injecting water. The invention paves basis for scaling manufacturing of the compound asparticitin gutta further, which improves the productivity with stable content of maleic chlorobenzenenamin.

Description

【Technical field】 [0001] The invention belongs to the technical field of ophthalmic medication, and in particular relates to a compound aspartic and vigan eye drop and a preparation method thereof. 【Background technique】 [0002] Compound Asparagine Vigan Eye Drops is also called Weimin Eye Drops, Compound Aspart Pan-Gan Eye Drops, which contains L-Aspartate Potassium, Vitamin B 6 , Dipotassium Glycyrrhizinate, Naphazoline Hydrochloride, Chlorpheniramine Maleate, Neostigmine Methyl Sulfate. Its properties are light yellow clear liquid. The pharmacological effects of the compound aspartic and vegan eye drops include: improving the adjustment function of the eyes, eliminating eye fatigue, and reducing conjunctival hyperemia. Indications: eye fatigue, conjunctival congestion, chronic conjunctivitis, chronic blepharitis and allergic conjunctivitis. [0003] Clinical trials of compound aspart Vigan eye drops have shown that it can inhibit and eliminate eye fatigue caused by co...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K9/08A61K47/34A61P27/02A61K31/198A61K31/27A61K31/4174A61K31/4402A61K31/4415A61K47/26
Inventor 杨文龙
Owner 江西闪亮制药有限公司
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