The present invention discloses an anti-aging blueberry health wine and a preparation method thereof, wherein the raw materials comprise, by weight, 10-15 parts of wild potentilla anserina l, 10-12 parts of jasmine flower, 15-20 parts of blueberry, 10-15 parts of fructus mume, 5-6 parts of lily, 3-4 parts of radix rehmanniae preparata, 5-7 parts of milkvetch root, 7-9 parts of coix seed, 2-4 parts of elsholtzia ciliata (thunb.) hyland., 800-1000 parts of high quality Baijiu, 5-6 parts of pearl powder, 2-4 parts of pomegranate leaf, 5-7 parts of celosia cristata l, 7-8 parts of aralia chinensis, 2-3 parts of herba abri, 0.1-0.3 part of a camellia oleifera abel leaf extract, 6-8 parts of compound nutrition powder, 6-7 parts of cornus officinalis, and 20-25 parts of white granulated sugar. According to the present invention, the health wine is mellow, smooth, fresh, fragrant and refreshing, has characteristics of sweet taste, light medicine incense, long aftertaste, and clear wine; various components synergistically act in the limited use amount range to provide the effects of liver nourishing, eyesight improving, spleen strengthening, stomach nourishing, spleen invigorating, qi benefiting, anti-aging, and human immunity enhancing; and the anti-aging blueberry health wine is suitable for all ages to drink.