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Application of potentilla anseriana extractive on preparating anti-ischemic

A technology of extract, fern, applied in the field of pharmaceutical products

Inactive Publication Date: 2008-06-25
LOGISTICS UNIV OF CAPF
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And so far Junima is only a kind of nourishing food in the Tibetan residential area, and it has not yet been prepared as a traditional Chinese medicine and has not appeared in the market.

Method used

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  • Application of potentilla anseriana extractive on preparating anti-ischemic
  • Application of potentilla anseriana extractive on preparating anti-ischemic
  • Application of potentilla anseriana extractive on preparating anti-ischemic

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preparation example Construction

[0020] The preparation method of the fern extract of the present invention is as follows:

[0021] Take the dried root tubers of Ferns, crush them, add 8 times the amount of 90% ethanol, reflux at 80°C for 2 hours, repeat twice, combine the extracts, concentrate under reduced pressure to a specific gravity of about 1.40g / ml, and obtain the alcoholic extract. Disperse the extract with 3 times the amount of water, sequentially extract 3 times with petroleum ether, ethyl acetate and n-butanol equivalent to 1 / 3 volume of the water dispersion system, combine the n-butanol liquid, concentrate under reduced pressure, and freeze-dry to obtain normal butanol site.

[0022] The following is the experimental description of the anti-ischemic effect of the n-butanol part of Juniba:

[0023] experiment one

[0024] Using the primary cardiomyocyte hypoxic injury model to prove the anti-myocardial hypoxia effect of the n-butanol part of Jupina 1. Method:

[0025] (1) Rat primary cardiomyoc...

Embodiment 1

[0094] Embodiment 1, the fern extract is made into tablet:

[0095] Butanol fraction of Bracken 50mg

[0096] Starch 25mg

[0097] 15% starch slurry appropriate amount

[0098] Magnesium Stearate Appropriate amount

[0099] The above formula is made into tablets according to traditional processing methods.

Embodiment 2

[0100] Embodiment 2, the fern extract is made into capsules:

[0101] Butanol fraction of Bracken 50mg

[0102] Starch 70mg

[0103] Prepared according to the traditional pharmaceutical process, put into No. 2 capsules.

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Abstract

The invention relates to an extractive of a potentilla anserina in the application of preparing the medicine for curing ischemic disease of heart and brain, and curing ischemia reperfusion injury of heart and brain. The ischemia and the ischemia reperfusion injury are the diseases which are seriously affected the health of human beings. With the change in the ageing of population and the life style of people, the category of disease has become a major disease which threatens the life of human being, especially the ischemia reperfusion injury is the common complicating disease of the percutaneous intervention of the present clinical cardiovascular PCI and bypass grafting. In the recent years, the scholars both abroad and at home take a lot of researches on using traditional Chinese medicine to cure the diseases of the ischemia and the ischemia reperfusion injury, and the researches show that the traditional Chinese medicine has strong tolerance to oxygen-poor organism and has good protection for the ischemia and the ischemia reperfusion injury. The extractive of the potentilla anserina in the invention proves that the traditional Chinese medicine has remarkable effects in curing the diseases of the ischemia and the ischemia reperfusion injury.

Description

technical field [0001] The invention relates to a pharmaceutical product, which is composed of the extract of Bracken japonica and a pharmaceutically acceptable carrier, and the product can be used for preventing and treating ischemic diseases. Background technique [0002] Potentilla anserina (Potentilla anserina L.) is the underground tuber of Potentilla velvet, a plant of the genus Potentilla in the family Rosaceae. It is known as "ginseng fruit" and is called "Zhuo Lao Sa Zeng" in Tibetan medicine. It mainly grows in the meadows and canals on the Qinghai-Tibet Plateau at an altitude of 2600m-4750m. It is a wild plant resource with wide distribution, large reserves, and natural high-quality. There are records in ancient times: "The whole herb of fern can be used as medicine to treat various bleeding and diarrhea, and the roots can be used as medicine to treat malnutrition, anemia after illness, spleen deficiency diarrhea, kidney deficiency and qi deficiency and other dise...

Claims

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Application Information

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IPC IPC(8): A61K36/73A61P9/10A61K125/00
Inventor 李灵芝张永亮张丽龚海英
Owner LOGISTICS UNIV OF CAPF
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