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Preparation method of medicine for treating peptic ulcers

A technology for peptic ulcer and medicines, which is applied in the field of preparation of medicines for treating peptic ulcers, can solve the problems of difficult solubility and loss of active ingredients in water, and achieve the effects of improving the efficacy and activity of medicines and saving and utilizing medicinal materials resources

Inactive Publication Date: 2014-11-12
徐继锋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicinal materials are mostly decocted in water, but some active ingredients are not easily soluble in water, or are lost during the decoction process. Therefore, in order to make better use of medicinal material resources, it is necessary to prepare pharmaceutical compositions method for research

Method used

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  • Preparation method of medicine for treating peptic ulcers
  • Preparation method of medicine for treating peptic ulcers
  • Preparation method of medicine for treating peptic ulcers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 The preparation of medicine of the present invention

[0028] Bracken 20g, Poria cocos 10g, capillary 7g, patchouli 7g, raw malt 7g, Magnolia officinalis 5g, perilla leaves 5g, stalks 5g; remove other herbs except fern, first add 10 times the amount of 85% ethanol solution Reflux extraction once, extract for 1 hour, filter, filtrate for later use, decoct the filter residue twice with water, add 8 times the amount of water each time, decoct for 30 minutes each time, combine the ethanol extract and water decoction, concentrate, and then add After granulating the fern powder, add an appropriate amount of magnesium stearate, and press into tablets to obtain the pharmaceutical tablet of the present invention.

Embodiment 2

[0029] Embodiment 2 The preparation of medicine of the present invention

[0030] Bracken 20g, Poria 10g, Capillary 7g, Patchouli 7g, Raw malt 7g, Magnolia officinalis 5g, Su Ye 5g, Su stem 5g; remove other medicinal flavors except Bracken, first add 10 times the amount of 95% ethanol solution Reflux extraction once, extract for 2 hours, filter, filtrate for later use, decoct the filter residue with water twice, add 10 times of water each time, decoct for 20 minutes each time, combine the ethanol extract and water decoction, concentrate, and then add Bracken powder, granules are obtained after granulation.

Embodiment 3

[0031] Embodiment 3 The preparation of medicine of the present invention

[0032] Bracken 20g, Poria cocos 10g, capillary 7g, patchouli 7g, raw malt 7g, Magnolia officinalis 5g, perilla leaf 5g, perilla stalk 5g; remove other medicinal flavors except fern, first add 10 times the amount of 55% ethanol solution Reflux extraction once, extract for 1 hour, filter, filtrate for later use, decoct the filter residue twice with water, add 8 times the amount of water each time, decoct for 30 minutes each time, combine the ethanol extract and water decoction, concentrate, and then add After granulating the fern powder, add an appropriate amount of magnesium stearate, and press into tablets to obtain the pharmaceutical tablet of the present invention.

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Abstract

The invention discloses a preparation method of a medicine for treating peptic ulcers. The method comprises the following steps: (1) weighing raw medicinal materials in parts by weight: 17 to 23 parts of potentilla anserina, 7 to 12 parts of poria cocos, 5 to 9 parts of oriental wormwood, 5 to 9 parts of pogostemon cablin, 5 to 9 parts of raw malt, 3 to 7 parts of mangnolia officinalis, 3 to 7 parts of perilla leaves and 3 to 7 parts of caulis perllae; (2) pulverizing the potentilla anserina to form powder for later use; firstly adding 55-95v / v% (volume per volume) ethyl alcohol into the other medicinal materials except for the potentilla anserina for extracting, filtering to obtain an alcohol extract for later use, decocting filter residue by adding water, combining the alcohol extract with the filter residue, concentrating and then adding the potentilla anserina powder and pharmaceutically acceptable auxiliary materials so as to obtain the medicine. The medicine is less in medicinal flavor according to a specific dosage proportion, and can be used for effectively treating gastric ulcers, duodenal ulcers and erosive gastritis, thereby providing a new medicine selection for clinic treatment of the peptic ulcers. Meanwhile, the pharmacological test proves that the pharmacological activity of the medicine is improved in manners of double alcohol-water extraction and pulverization of the potentilla anserina into medicinal powder, so that the economical utilization of medicinal material resources is realized.

Description

technical field [0001] The invention relates to a preparation method of a medicine for treating peptic ulcer. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum. Among them, gastric and duodenal ulcers refer to localized circular or oval full-thickness defects of the gastric and duodenal mucosa, the muscularis mucosa is penetrated, and fibrous scars are inevitably left after healing. Covered by epithelium, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as fullness aft...

Claims

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Application Information

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IPC IPC(8): A61K36/8998A61P1/04
Inventor 徐继锋
Owner 徐继锋
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