40results about How to "Enhance pharmacodynamic activity" patented technology

The invention provides a pharmaceutical composition for treating liver fibrosis. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 0-16 parts of American cockroach, 3-24 parts of turtle shell, 4-30 parts of astragalus membranaceus and 3-60 parts of lysimachia christinae hance. The invention also provides a preparation method and an application of the pharmaceutical composition. After being combined in use, the medicines play a synergistic interaction effect, so that the pharmaceutical activity is remarkably increased, the ALT level and the AST level of plasma of a body with liver fibrosis can be reduced, the Hyp level and the Collagen I level of liver tissues can be reduced, the liver fibrosis can be effectively treated and a new choice is provided for clinical medication.

The invention discloses a preparation method of valerian root total alkaloid extract, which comprises extracting valerian root with water and / or an ethanol solution containing 0.1-0.5% hydrochloric acid, extracting the extract with an organic solvent, and finally extracting the extracted part Macroporous adsorption resin purification in three steps. The invention can separate and purify the high-concentration total alkaloid extract from the valerian medicinal material, and the prepared extract has high medicinal activity.

The invention provides an anti-cancer pellet. The anti-cancer pellet is a preparation which is prepared from the following materials and the auxiliary material in parts by weight: 1 part of material medicines including rheum emodin, sophoridine and sophocarpidine in a ratio of (20-100):(250-2000):(500-2500) and 0.5-2 parts of auxiliary material including diluents. The invention further provides an anti-cancer colonic targeting agent and a preparation method of each preparation. According to the anti-cancer pharmaceutical composition, rheum emodin, sophoridine and sophocarpidine are selected from a plurality of anti-tumor natural medicines and reasonably combined, so that a synergistic interaction effect is brought into play, anti-tumor activity of single medicine is remarkably improved; meanwhile, the dispensed medicines are prepared into the colonic targeting agent and each medicine generates effects to colonic infection focuses, so that not only pesticide effect activity can be improved, but also side effects of digestive systems including a stomach, small intestines and the like can be reduced, and therefore, novel medicine choices are provided for treating the colorectal cancer.