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A pharmaceutical composition for treating liver fibrosis, its preparation method and application

A technology of liver fibrosis and composition, which is applied in the field of pharmaceutical composition for treating liver fibrosis and its preparation and application, can solve the problems of lack of high-efficiency western medicine, etc., achieve the improvement of drug efficacy and activity, reduce plasma ALT and AST levels, reduce horizontal effect

Active Publication Date: 2018-05-01
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies have confirmed that liver fibrosis may be reversed before it enters liver cirrhosis, which brings new hope for the effective treatment of liver fibrosis, but there is still a lack of high-efficiency, non-obvious side effects of Western medicine in clinical practice

Method used

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  • A pharmaceutical composition for treating liver fibrosis, its preparation method and application
  • A pharmaceutical composition for treating liver fibrosis, its preparation method and application
  • A pharmaceutical composition for treating liver fibrosis, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0035] Take 10g of Periplaneta americana, 21g of Turtle Shell, 7g of Radix Astragali, and 27g of Desmodium, extract with 30-70% v / v ethanol, and combine the extracts to obtain the pharmaceutical composition of the present invention.

Embodiment 2

[0036] Embodiment 2 Preparation of the pharmaceutical composition of the present invention

[0037] Take 10g of Periplaneta americana, 21g of Turtle Shell, 7g of Astragalus, and 27g of Desmodium; after extracting with water, combine the extracts to obtain the pharmaceutical composition of the present invention.

Embodiment 3

[0038] Embodiment 3 Preparation of the pharmaceutical composition of the present invention

[0039]Take 10g of Periplaneta americana, 21g of Turtle Shell, 7g of Radix Astragali, and 27g of Desmodium; extract with 30-40% v / v ethanol, and combine the extracts to obtain the pharmaceutical composition of the present invention.

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PUM

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Abstract

The invention provides a pharmaceutical composition for treating liver fibrosis. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 0-16 parts of American cockroach, 3-24 parts of turtle shell, 4-30 parts of astragalus membranaceus and 3-60 parts of lysimachia christinae hance. The invention also provides a preparation method and an application of the pharmaceutical composition. After being combined in use, the medicines play a synergistic interaction effect, so that the pharmaceutical activity is remarkably increased, the ALT level and the AST level of plasma of a body with liver fibrosis can be reduced, the Hyp level and the Collagen I level of liver tissues can be reduced, the liver fibrosis can be effectively treated and a new choice is provided for clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating liver fibrosis, a preparation method and application thereof. Background technique [0002] Hepatic fibrosis (Hepatic Fibrosis, HF) is a common pathological feature of most chronic liver diseases, and it is also an important intermediate link in the further development and deterioration of chronic hepatitis and cirrhosis. Mainly under the action of various injury factors, hepatic stellate cell (HSC) activates, proliferates, synthesizes and secretes a large amount of extracellular matrix (ECM), degrades, reduces and deposits more, and forms liver fibrosis . There are many causes of liver fibrosis. In foreign countries, especially in European and American countries, alcoholism accounts for the majority (about 50% to 80%). In my country, the main cause of liver fibrosis is infection with hepatitis virus. Among HBV-infected patients, 10% to 15% of patients can develop chronic HBV infecti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61P1/16A61K35/586A61K35/64
CPCA61K35/586A61K36/185A61K36/481A61K36/53A61K2236/331A61K2236/333A61K2300/00
Inventor 苏柘僮熊永爱邹俊波
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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