Granule for treating peptic ulcer and preparation method of granule

A technology for peptic ulcer and granules, which is applied in the field of granules for the treatment of peptic ulcer and its preparation, which can solve the problems of difficult solubility and loss of active ingredients in water, and achieve the effect of improving drug efficacy and activity and reasonable compatibility

Inactive Publication Date: 2015-12-30
CHENGDU HENGLING TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, traditional Chinese medicinal materials are mostly decocted in water, but some active ingredients are not easily soluble in water, or are lost during the decoction process. Therefore, in order to make better use of medicinal material resources, it is necessary to prepare pharmaceutical compositions method for research

Method used

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  • Granule for treating peptic ulcer and preparation method of granule
  • Granule for treating peptic ulcer and preparation method of granule
  • Granule for treating peptic ulcer and preparation method of granule

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 granule of the present invention

[0038] Atractylodes macrocephala 10g, Poria cocos 10g, red bean 10g, astragalus 7.5g, capillary 7.5g, dandelion 7.5g, bitter almond 5g, bellflower 5g, patchouli 5g, dried ginger 2.5g, ginseng 2.5g; other herbs except ginseng , first add 10 times the amount of 70% ethanol solution for reflux extraction once, extract for 1 hour, filter, and use the filtrate for later use, and decoct the filter residue twice with water, add 8 times the amount of water each time, decoct for 30 minutes each time, and combine the ethanol extract After decoction with water, concentrate to a thick paste with a relative density of 1.28-1.30 (60°C), then add ginseng powder, and soluble starch: dextrin = 1:1, a total of 43-44g, wet granulation, and dry, that is Obtain the granule of the present invention.

[0039] After measuring, the dry paste rate of the extraction method of the present invention is 29~30% (dry paste amount acco...

Embodiment 2

[0040] The selection of embodiment 2 granule auxiliary materials

[0041] 1 Effect of different excipients on granulation

[0042] Weigh three portions of thick paste (about 17g) according to the dry weight of the extract 10g, add dried soluble starch, dextrin, soluble starch-dextrin (1:1), soluble starch-dextrin (1:3), Soluble starch-dextrin (1:5) 13g each, mixed evenly, granulated without adding ethanol, investigated the soft material, the difficulty of sieving, and the appearance of the granules, the results are shown in Table 1.

[0043] Table 1 Effect of excipients on granulation

[0044]

[0045] Conclusion: When the soluble starch-dextrin ratio is (3:1) and (1:1), the granulation is better, the granules have deep color and uniform particle size.

[0046] 2 Investigation of the moisture absorption rate and solubility of different excipients on the particles

[0047] Take a glass desiccator filled with NaCl supersaturated solution at the bottom, a weighing bottle is...

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Abstract

The invention discloses a granule for treating a peptic ulcer. The granule is prepared from the following raw and auxiliary materials in parts by weight: 7-13 parts of rhizoma atractylodis macrocephalae, 7-13 parts of poria cocos, 7-13 parts of phaseolus calcaratus, 5-10 parts of astragalus membranaceus, 5-10 parts of herba artemisiae scopariae, 5-10 parts of dandelion, 3-7 parts of semen armeniacae amarum, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin, 2-3 parts of rhizoma zingiberis and 2-3 parts of ginseng. Through specific usage and ratio, the medicines are relatively few; a gastric ulcer, a duodenal ulcer and erosive gastritis can be effectively treated; a new medication choice is provided for clinical treatment of the peptic ulcer; meanwhile, through a pharmacodynamic test, the pharmacodynamic activity can be improved by using a manner that alcohol and water double extraction is adopted and ginseng powder is taken as a raw material; and economical utilization of medicinal material resources is facilitated.

Description

technical field [0001] The invention relates to a granule for treating peptic ulcer and a preparation method thereof. Background technique [0002] Peptic ulcer mainly refers to chronic ulcers that occur in the stomach and duodenum. Among them, gastric and duodenal ulcers refer to localized circular or oval full-thickness defects of the gastric and duodenal mucosa, the muscularis mucosa is penetrated, and fibrous scars are inevitably left after healing. Covered by epithelium, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic erosive gastritis, also known as verrucous gastritis or pimple-like gastritis, generally only sees dyspepsia symptoms such as full...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61K47/36A61P1/04
Inventor 李智叶英徐继锋
Owner CHENGDU HENGLING TECH CO LTD
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