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Preparation method of compound isatis root electuary

The technology of compound isatidis and isatidis is applied in the field of preparation of compound isatis root granules, which can solve the problems of decreasing the retention rate of active ingredients, affecting the quality of preparations and clinical efficacy, etc., so as to improve the pharmacodynamic activity, prolong the storage period and slow down the speed. Effect

Inactive Publication Date: 2016-03-30
广西众森医药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The literature shows that Gao Yichun and nucleosides are the main antiviral active ingredients in Radix isatidis preparations, and most of them contain amide groups, which are easy to decompose under high temperature and acidic conditions, resulting in a decrease in the retention rate of active ingredients
Traditional Radix Radix preparations often go through a long heat treatment process, and the thermal stability of the index components will directly affect the transmission of information chains in the production process of traditional Chinese medicine, so it will seriously affect the quality and clinical efficacy of subsequent preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Weigh 50 parts of Radix Radix, 25 parts of Forsythia, and 25 parts of Licorice Root, remove mud and impurities, rinse with water, dry in an oven to constant weight, and set aside;

[0020] (2) Put the forsythia in the reactor, add 4 times and 3 times the amount of ethanol with a mass fraction of 60%, respectively, heat to 78° C., heat and reflux in a water bath for extraction for 2 hours and 1 hour, filter respectively, and combine the extracts;

[0021] (3) Put the forsythia dregs, Banlangen, and licorice in the step (2) in a vacuum extraction device, add 2 times the amount of distilled water, vacuumize the system until the absolute pressure of the system is 75Pa, heat to 50°C and extract twice by boiling , 2 hours for the first time, 1 hour for the second time, filter, and combine the extracts;

[0022] (4) merging the extracts in steps (2), (3), reclaiming ethanol, and concentrating the extract under reduced pressure into an extract whose relative density is 1.2;...

Embodiment 2

[0025] (1) Weigh 60 parts of Radix Radix, 20 parts of Forsythia, and 20 parts of Licorice Root, remove mud and impurities, rinse with water, dry in an oven to constant weight, and set aside;

[0026] (2) Put the forsythia in the reactor, add 3 times and 2 times the amount of ethanol with a mass fraction of 70% respectively, heat to 80° C., heat and reflux in a water bath to extract for 3 hours and 2 hours, filter respectively, and combine the extracts;

[0027] (3) Put the forsythia dregs, Banlangen, and licorice in the step (2) in a vacuum extraction device, add 3 times the amount of distilled water, vacuumize the system until the absolute pressure of the system is 100Pa, heat to 55°C and extract twice by boiling , 2.5h for the first time, 1.5h for the second time, filter, and combine the extracts;

[0028] (4) merging the extracts in steps (2), (3), reclaiming ethanol, and concentrating the extract under reduced pressure into an extract whose relative density is 1.3;

[002...

Embodiment 3

[0031] (1) Weigh 34 parts of Radix Isatidis, 33 parts of Forsythia, and 33 parts of Licorice Root, remove mud and impurities, rinse with water, dry in an oven to constant weight, and set aside;

[0032] (2) Put the Forsythia japonicus into the reactor, add 2 times and 1 times the amount of ethanol with a mass fraction of 80% respectively, heat to 79°C, heat and reflux in a water bath to extract for 2h and 1h, filter respectively, and combine the extracts;

[0033] (3) Put the forsythia dregs, Banlangen, and licorice in the step (2) in a vacuum extraction device, add 4 times the amount of distilled water, vacuumize the system until the absolute pressure of the system is 90Pa, heat to 60°C and extract twice by boiling at low temperature , 2 hours for the first time, 1 hour for the second time, filter, and combine the extracts;

[0034] (4) the extracts in steps (2), (3) are combined, ethanol is reclaimed, and the extract is concentrated into an extract whose relative density is ...

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Abstract

The invention discloses a preparation method of compound isatis root electuary. The preparation method utilizes low-temperature boiling pressure reduction extraction on medicinal materials such as isatis root. Compared with the conventional extraction method, the preparation method improves an effective component recovery rate, delays a thermal degradation speed and prolongs an intermediate soup storage life and a final product validity period and improves activity of pharmacodynamics. The vacuum extraction method has a wide application prospect for heat sensitive component-containing medicinal material extraction.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, and in particular relates to a preparation method of a compound isatidis granule. Background technique [0002] Banlangen is the dry root of Isantis indigotica Fort., a plant of the genus Isatis in the family Cruciferae. It is bitter and cold in taste, and has the effects of clearing away heat, detoxifying, cooling blood, and relieving sore throat. It is a representative drug of heat-clearing and detoxifying traditional Chinese medicine. The production and sales volume of Isatidis preparations is the most among Chinese patent medicines. The single preparations alone include more than ten varieties including Isatidis Granules, Isatidis Tablets, Isatidis Oral Liquid, Isatidis Capsules, Isatidis Dropping Pills, and Isatidis Dispersible Tablets. [0003] The literature shows that Gao Yichun and nucleosides are the main antiviral active ingredients in Radix isatidis preparations, and most ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/16
CPCA61K36/195A61K9/1623A61K36/315A61K36/484A61K36/634A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 谢翔
Owner 广西众森医药集团有限公司
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