The invention relates to a micro-interface enhanced reactor bubble scale structure-activity regulation and control model building method. The diameter dmax of the largest bubble of a micro-interface enhanced reactor and the diameter dmin of the smallest bubble of the micro-interface enhanced reactor serve as independent variables, the average diameter d32 of the bubble Sauter serve as a dependentvariable, and a numerical relationship is built; based on the Kolmogorov-Hinze theory, the relationship between the diameter dmax of the largest bubble of the micro-interface enhanced reactor, the diameter dmin of the smallest bubble and the parameters of the reactor is built. According to the method, the reactor bubble scale is associated with the structural parameter, the operation parameter andthe physical property parameter of the reactor by using specific numerical relationship, the numerical relationship has the guiding significance for the design of the reactor and can be applied to avariety of reactors, the versatility is good, by means of a bubble scale regulation and control model built through the method, by adjusting the structural parameter and the operation parameter of thereactor, and the maximization of energy efficiency and material efficiency in the reaction process can be achieved, or under the condition that reaction targets, energy consumption and material consumption are given, a high-efficiency reactor structure is designed.