Application of sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs

A technology of sesquiterpene glycosides and compounds, which is applied in the application field of sesquiterpene glycoside monomer compounds in the preparation of lipid-lowering drugs, which can solve the problems of less monomer components, failure to effectively utilize natural drug resources, and unfavorable basic pharmacological research, etc. problem, to achieve the effect of preparation method optimization, repeatability of large preparation operations, and simple steps

Inactive Publication Date: 2021-06-29
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, crude extracts of total triterpenic acids, total flavonoids and total sesquiterpene glycosides of loquat leaves, which have lipid-lowering effects, have been extracted respectively from loquat leaves, but there are relatively few studies on the effective monomer components. It can effectively utilize natural drug resources, and at the same time only for the research of the total extract, it is not conducive to the basic research of pharmacology

Method used

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  • Application of sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs
  • Application of sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs
  • Application of sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation Example of Semiphethinder Monomer Compound

[0032] Such as figure 2 As shown, the dri is taken 10 kg, 80% ethanol (from 1: 10) 1: 6 ~ 1: 10, it can be added) refluxed 2 times (or extraction extraction of 3 times at room temperature), combined extract Filtration, concentrated under reduced pressure to precipitate precipitation, centrifugation of 3000 rpm for 15 minutes, take the supernatant.

[0033] The supernatant slowly was slowly adsorbed with the resin column, and was eluted in sequential water, 40%, 60%, 80% ethanol gradient. 60% ethanol elution moiety was combined after high performance liquid phase detection, concentrated under reduced pressure and spare.

[0034] The concentrate further flows through the treated polyamide column chromatography (200 mesh), water-ethanol gradient elution. After high-performance liquid phase detection, the water wash portion was analyzed. After the reduced pressure was concentrated, further transfected with the RP-18 rever...

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Abstract

The invention discloses application of a sesquiterpene glycoside monomeric compound in preparation of lipid-lowering drugs or health care products. The chemical formula of the sesquiterpene glycoside monomeric compound is nerolidol-3-O-alpha-L-rhaminopyranosyl- (1 to 2)-[alpha-L-rhaminopyranosyl-(1 to 6)]-beta-D-glucopyranoside.

Description

Technical field [0001] The present invention relates to a presence of a natural extracting monomeric compound. Background technique [0002] Obesity is a chronic metabolic disease with insulin resistance as the main cause, which is characterized by damage to islet beta cell function and surrounding tissue (eg, skeletal muscle, adipose tissue and liver) due to damage to insulin signaling. Sexually weakened. Therefore, increasing insulin sensitivity, promoting the ingestion of organ tissue on lipids and metabolism is an important entry point for the treatment of obesity. [0003] The dry leaves of the roses are 枇杷 [Eriobotrya Japonica (Thunb.) Lindl.] Is widely distributed in China, is a common traditional Chinese medicine, taste, sexy and cold, with clear lung cough, anti-vomiting, anti-oxidation , Anti-inflammatory and liver liver protection. Used in the treatment of pulmonary heat cough, gas in gas, gastric and vomiting, annoying and thirst, etc., in line with traditional Chines...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7028A61K36/73A61P3/06A61P3/04A61P5/50A61P1/16C07H15/04C07H1/08A61K127/00
CPCA61K31/7028A61K36/73A61P3/06A61P3/04A61P5/50A61P1/16C07H15/04C07H1/08
Inventor 简暾昱丁晓琴陈剑吕寒牛冠婷童贝赵磊刘艳任冰如李维林
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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