41results about How to "Good lipid-lowering activity" patented technology

The invention relates to an anti-obesity compound and a preparing method and application thereof. The compound structural formula is shown as the formula (I), or the formula (II) or the formula (III).The anti-obesity compound has high lipid-decreasing activity and is capable of effectively suppressing fat cell differentiation and reducing the lipid level in fat cells, high in stability and low intoxicity. In addition, the anti-obesity compound is prepared through a three-step method, the preparing process is simple and short in time and includes few reaction steps, and aftertreatment is easy.

The invention discloses a marine fungus, novel skeleton meroterpenoid derivatives prepared from the marine fungus as well as a preparation method and application of the novel skeleton meroterpenoid derivatives. The marine fungus Aspergillus terreus GZU-31-1 is preserved in Guangdong Microbiological Culture Collection Center on December 17, 2019 and has a preservation number of GDMCC No:60789. Sixnovel skeleton meroterpenoid derivatives are separated from fermented liquid of the marine fungus, have novel structures and are capable of remarkably reducing the activity of triglyceride; particularly, when the concentrations of the compounds 1-5 are 2 microliters and 5 microliters, the content of triglyceride in cells is remarkably reduced; especially the lipid decreasing activity of the compound 1 at a concentration of 5 microliters is even superior to that of a positive control, namely berberine at the same concentration. The compounds provided by the invention have a great application value to lipid decreasing and can be prepared into lipid decreasing drugs for use.

The invention discloses a gynostemma pentaphylla extract and a preparation method thereof; the gynostemma pentaphylla extract contains 50-99% by mass of a saponin compound; the invention specificallydiscloses a structure of the saponin compound. The gynostemma pentaphylla extract provided by the invention has remarkable lipid-lowering activity, and the preparation method is simple and convenientand has good economic benefits and application prospects.

The invention belongs to the technical field of pharmaceutical chemistry, and relates to hypolipidemic compounds, a preparation method thereof and a purpose thereof. According to the novel compounds with hypolipidemic activity, a rubiaceae plant geophilaherbacea is adopted as a raw material, and novel 2,6-phenethanol dihydroxybenzoate is obtained by separation and identification through a solvent extraction and chromatography method. According to the invention, substituted aryl acid and substituted aryl alcohol are adopted as raw materials, and are subject to a reaction in an appropriate solvent with the effect of a catalyst under a certain temperature, such that 2,6-phenethanol dihydroxybenzoate and similar substances are produced. The compounds show substantial hypolipidemic effects in hypolipidemic models, and can be used for preparing novel hypolipidemic medicines. The extraction, separation, synthesis and preparation methods disclosed by the invention are advantaged in mild reaction condition, easy operation, and high yield.

The invention relates to a resveratrol derivative and application thereof to a medicament, and particularly discloses a compound shown as a formula I or pharmaceutically acceptable salt, ester, solvate and stereoisomers thereof. In the formula I, R1, R2 and R3 are independently selected from a hydrogen atom, C1 to C3 alkyl or a substituted group shown as a formula i; at least one of R1, R2 and R3 is the substituted group shown as the formula i; R is selected from the hydrogen atom, substituted or unsubstituted C1 to C5 alkyl, substituted or unsubstituted C3 to C6 naphthenic base, benzyl or phenyl; R4 and R5 are independently selected from the hydrogen atom, the substituted or unsubstituted C1 to C5 alkyl, or substituted or the unsubstituted C3 to C6 naphthenic base; and n is an integer of between 1 and 5. The invention also discloses a medicinal composition containing the compound shown as the formula I, and the application of the compound shown as the formula I to the preparation of a medicament for treating and/or preventing cardiovascular and cerebrovascular diseases. The compound shown as the formula I can be effectively used for treating and/or preventing the cardiovascular and cerebrovascular diseases such as hyperlipemia.

The invention discloses composite seaweed polysaccharide oral liquid for reducing blood lipid and a preparation method of the composite seaweed polysaccharide oral liquid. The composite seaweed polysaccharide oral liquid for reducing blood lipid is prepared from the following components in percentage by mass: 60-90% of a seaweed polysaccharide extract, 1-10% of a haw extract, 1-10% of a lotus leaf extract, 1-10% of a ginkgo leaf extract, 1-10% of a mulberry leaf extract and 0.01-10% of a sweetening agent, wherein the seaweed polysaccharide extract is obtained through extraction with high-pressure steam. The preparation method comprises the following steps of mixing the components in percentage by mass to obtain a mixture, performing cold storage on the mixture, performing centrifugation to obtain a supernatant, performing filling, performing covering, and performing sterilization so as to obtain the composite seaweed polysaccharide oral liquid for reducing blood lipid. According to the composite seaweed polysaccharide oral liquid and the preparation method thereof disclosed by the invention, polysaccharide and polyphenol substances having the efficacy of reducing blood lipid are in synergy and are compounded, the preparation method is simple in steps, the synergistic interaction of seaweed polysaccharides and polyphenols is used for strengthening the efficacy of the seaweed polysaccharides for reducing blood lipid, and the purpose of enhancing the efficacy of the finished products for reducing blood lipid can be achieved.

The invention relates to a resveratrol derivative and a medical application thereof, and in particular discloses a compound in a formula I as shown in the specification or pharmaceutically acceptable salt, ester, solvate and stereoisomer thereof, wherein R1, R2 and R3 are respectively independently selected from hydrogen atom, C1-C3 alkyl groups, or a substituent group in a formula i as shown in the specification, at least one of R1, R2 and R3 is selected from the C1-C3 alkyl groups, and simultaneously at least one of R1, R2 and R3 is selected from the substituent group in the formula i; R is selected from hydrogen atom, substituted or unsubstituted C1-C5 alkyl groups, substituted or unsubstituted C3-C6 naphthenic groups, benzyl groups or phenyl groups; and R4 and R5 are respectively independently selected from hydrogen atom, substituted or unsubstituted C1-C5 alkyl groups, or substituted or unsubstituted C3-C6 naphthenic groups. The invention also discloses a pharmaceutical composition containing the compound in the formula I, and the application of the compound in the formula I in preparing medicines for treating and/or preventing cardiovascular and cerebrovascular diseases. The compound in the formula I provided by the invention can be effectively used for treating and/or preventing the cardiovascular and cerebrovascular diseases such as hyperlipidaemia.

The invention provides a benzophenone dimer compound, or a pharmaceutically acceptable salt or an optical isomer of the benzophenone dimer compound. Meanwhile, the invention further provides application of the compound in preparation of products for lowering lipid, whitening and the like.

The invention discloses a dihydroartemisinin-containing carboxy phenol/ester phenol/amido phenol conjugate. The conjugate or a racemate, stereoisomer and tautomer thereof and a pharmaceutically acceptable salt of the conjugate have a structural general formula as shown in a formula I, wherein n is equal to 2 or 3, X is an alkoxyl, a hydroxyl, an amino group or -O(CH2)b-DHA, Y is -H or an alkoxyl,Z is an alkenyl and an alkyl or has no groups, b is equal to 2 or 3, and DHA represents for dihydroartemisinin. The invention further discloses a synthesis method of the dihydroartemisinin-containingcarboxy phenol/ester phenol/amido phenol conjugate and an application of the conjugate as a drug for resisting to tuberculosis and diabetes mellitus, reducing blood fat and inhibiting interleukin-17.

The invention provides a medicated diet therapy product composition for hyperlipemia and fatty liver. The medicated diet therapy product composition is prepared from the following raw materials in parts by weight: 1-15 parts of hippophae rhamnoides leaves, 1-20 parts of moringa oleifera leaves, 1-15 parts of chicory, 1-20 parts of emblic leafflower fruits, 1-20 parts of purslane, 1-20 parts of cassia seeds, 1-15 parts of wild radix puerariae, 1-15 parts of fructus perillae, 1-20 parts of fructus cannabis, 1-16 parts of kelp, 1-15 parts of lotus leaves, 0.1-3 parts of chitosan oligosaccharide and 0.5-5 parts of xylooligosaccharide. The invention also provides a preparation method of the medicated diet and dietary therapy product composition for hyperlipidemia and fatty liver. The medicateddiet and dietary therapy product composition for hyperlipidemia and fatty liver has the characteristics of definite curative effect, clear action target and pharmacological effect, wide raw material source, low cost, simple preparation method, high patient compliance and the like, and can effectively prevent and treat hyperlipidemia and relieve related symptoms caused by hyperlipidemia.

The invention discloses a saffron crocus petal refined alcohol extract, and a preparation method and application thereof, and belongs to the technical field of saffron crocus active ingredient extraction. The preparation method comprises the following steps: S1, carrying out low-temperature plasma treatment; S2, carrying out subzero treatment; S3, carrying out superfine grinding treatment; S4, performing low-temperature vacuum drying treatment; S5, carrying out primary alcohol extraction; S6, carrying out secondary alcohol extraction; and S7, carrying out purification treatment. According to the saffron crocus petal refined alcohol extract, and the preparation method and application thereof provided by the invention, after the prepared saffron crocus petal refined alcohol extract is subjected to intragastric administration on a mouse, the weight increment and the food intake of the mouse are not remarkably different from those of a normal control group; therefore, the saffron crocus petal refined alcohol extract prepared by the method provided by the invention has relatively low influence on the appetite of the mouse and relatively small stimulation on the digestive system of the mouse. The saffron crocus petal refined alcohol extract prepared by the method disclosed by the invention has obvious blood fat reducing activity, that is, the saffron crocus petal refined alcohol extract prepared by the method disclosed by the invention is high in extraction rate and relatively high in activity.

The invention relates to cyclocarya paliurus mogroside. The cyclocarya paliurus mogroside is obtained by performing water or alcohol extraction on cyclocarya paliurus leaves, passing through macroporous adsorption resin, and sequentially eluting with water and an ethanol solution. The preparation method comprises the following steps: adding a proper amount of cyclocarya paliurus leaves into water or ethanol, heating, refluxing and extracting, combining extracting solutions, and concentrating under reduced pressure to obtain a concentrated solution; enabling the concentrated solution to pass through a macroporous adsorption resin column, and sequentially eluting with water, a 15-25% ethanol solution and a 75-85% ethanol solution respectively; concentrating the 75-85% ethanol elution part under reduced pressure until no alcohol smell exists, adding water for suspension, extracting with ethyl acetate, and recovering the solvent to obtain a cyclocarya paliurus leaf sweet part; decoloring sweet parts of the cyclocarya paliurus leaves; and drying to obtain the cyclocarya paliurus mogroside. The cyclocarya paliurus mogroside or the cyclocarya paliurus mogroside prepared by the method can be used for preparing a medicine with a lipid-lowering function, or can be used for common food or health food, or can be directly used as a food additive such as a sweetening agent, an aromatic and the like.