A class of tiglicane type diterpene compound and its preparation method and application

A technology for tiglicane and compounds, which is applied in the field of natural compounds and their preparation to achieve the effects of good lipid-lowering activity and low cytotoxicity

Active Publication Date: 2020-04-17
SUN YAT SEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, most of the research is focused on molecular design and chemical synthesis, and few researchers develop weight-loss drugs through the huge treasure trove of natural products.

Method used

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  • A class of tiglicane type diterpene compound and its preparation method and application
  • A class of tiglicane type diterpene compound and its preparation method and application
  • A class of tiglicane type diterpene compound and its preparation method and application

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Embodiment Construction

[0047] The technical solutions of the present invention will be further described below in conjunction with the embodiments.

[0048] In the present invention, various plants of Euphorbiaceae (taking Croton as an example) are studied.

[0049] Equipment and reagents: NMR spectra were recorded by Bruker AM-400 spectrometer with TMS internal standard. Column chromatography silica gel (300-400 mesh): Qingdao Ocean Chemical Factory; GF 254 Silica gel thin-layer chromatography prefabricated plate: Qingdao Ocean Chemical Factory; MCI packing (CHP20P, 75-150 μm): Japan Mitsubishi Company; Sephadex LH-20: American GE Company; ODS packing (12 nm, S -50 μm): Japan YMC Company; other solvents and reagents: analytical grade (AR), Tianjin Best Chemical Co., Ltd.

[0050] Preparation of croton extract

[0051]Get croton 30kg, pulverize into coarse powder. Add 3 times the volume of 95% ethanol, soak for 1 week, sonicate for 2 days, filter under reduced pressure, and recover ethanol under...

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Abstract

The invention discloses Tigliane-type diterpenoid compounds and a pharmaceutically acceptable derivative thereof. The general formula of the Tigliane-type diterpenoid compounds is as shown in the specification. The inventor applies the Tigliane-type diterpenoid compounds in the aspects of lowering lipid and treating obesity for the first time. Lipid-lowering activity experimental results show thatthe Tigliane-type diterpenoid compounds have low cytotoxicity and good lipid-lowering activity and are expected to be developed into new lipid-lowering drugs or health products. Especially the compound YGGZ-2 has the potential of being developed into new lipid-lowering or fat-reducing drugs or health products.

Description

technical field [0001] The invention relates to a natural compound and its preparation method and application, in particular to a class of tiglicane type diterpene compounds and its preparation method and application. Background technique [0002] Obesity refers to a physical condition caused by a certain degree of fat accumulation in the body. The standard of obesity is often measured by body mass index (BMI), which is divided by the square of the weight divided by the height (kg / m 2 ), when BMI is greater than 30 kg / m 2 is obese. In recent years, obesity has become a global epidemic. According to the World Health Organization, more than 1.9 billion adults were overweight in 2016, and more than 650 million people were obese. At least 2.8 million deaths a year can be attributed to overweight or obesity, and there is a trend of younger age. Obesity has become one of the most important public health problems in the 21st century. [0003] Studies have shown that obesity is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/21C07C69/18C07C69/78C07C69/30C07C69/533C07C69/03C07C69/013C07C67/48C07C67/56C07C67/58C07C49/753C07C49/727C07C45/78C07C45/79C07C45/80C07C35/44C07C29/74C07C29/76C07C29/86A61K31/216A61K31/22A61K31/122A61K31/047A61P3/06A61P3/04A23L33/105
CPCA23L33/105A23V2002/00A61P3/04A61P3/06C07B2200/07C07C35/44C07C49/727C07C49/753C07C69/013C07C69/18C07C69/21C07C69/30C07C69/533C07C69/78C07C2603/40A23V2200/3262A23V2200/332A23V2250/21
Inventor 尹胜黄志纾饶勇唐贵华宋芹芹
Owner SUN YAT SEN UNIV
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