Pharmaceutical composition for treating liver fibrosis as well as preparation method and application of pharmaceutical composition

Abstract

The invention provides a pharmaceutical composition for treating liver fibrosis. The pharmaceutical composition is a preparation prepared from the following raw medicines in parts by weight: 0-16 parts of American cockroach, 3-24 parts of turtle shell, 4-30 parts of astragalus membranaceus and 3-60 parts of lysimachia christinae hance. The invention also provides a preparation method and an application of the pharmaceutical composition. After being combined in use, the medicines play a synergistic interaction effect, so that the pharmaceutical activity is remarkably increased, the ALT level and the AST level of plasma of a body with liver fibrosis can be reduced, the Hyp level and the Collagen I level of liver tissues can be reduced, the liver fibrosis can be effectively treated and a new choice is provided for clinical medication.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating liver fibrosis, a preparation method and application thereof. Background technique [0002] Hepatic fibrosis (Hepatic Fibrosis, HF) is a common pathological feature of most chronic liver diseases, and it is also an important intermediate link in the further development and deterioration of chronic hepatitis and cirrhosis. Mainly under the action of various injury factors, hepatic stellate cell (HSC) activates, proliferates, synthesizes and secretes a large amount of extracellular matrix (ECM), degrades, reduces and deposits more, and forms liver fibrosis . There are many causes of liver fibrosis. In foreign countries, especially in European and American countries, alcoholism accounts for the majority (about 50% to 80%). In my country, the main cause of liver fibrosis is infection with hepatitis virus. Among HBV-infected patients, 10% to 15% of patients can develop chronic HBV infecti...

AI Technical Summary

Problems solved by technology

In recent years, studies have confirmed that liver fibrosis may be reversed before it enters liver cirrhosis, which brings new hope for the effective treatment of liver fibrosis, but there is still a lack of high-efficiency, non-obvious side effects of Western medicine in clinical practice

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