Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aspartic vitamin eye drops and preparation method thereof

A technology of eye drops and aspartic acid, which is applied in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the complex drug composition of compound aspartame eye drops, etc. problem, to achieve the effect of stable content, optimized preparation process and high yield

Active Publication Date: 2010-02-03
江西闪亮制药有限公司
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, due to the complex drug composition of the compound aspart and Vigan eye drops, there are 6 kinds of chemical drugs in total, how to ensure that the eye drops will not be turbid, deteriorated and solution state in a large temperature range or a long storage time Uniformity and stability is also a problem that needs to be seriously solved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 【prescription】

[0024] Aspartic Acid 7.8g

[0025] Vitamin B 6 0.5 grams

[0026] Dipotassium Glycyrrhizinate 1.0g

[0027] Naphazoline Hydrochloride 0.03g

[0028] Neostigmine Methosulfate 0.05g

[0029] Chlorpheniramine Maleate 0.1g

[0030] Polysorbate 80 1.0 g

[0031] Sodium chloride 7.0 g

[0032] Menthol 0.1g

[0033] Benzalkonium Chloride 0.1g

[0034] 1 mol / L sodium hydroxide solution Appropriate amount

[0035] Add water for injection to 1000ml

[0036]

[0037] Makes 1000ml

[0038] 【Method】

[0039] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0040] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added to the ...

Embodiment 2

[0044] 【prescription】

[0045] Aspartic Acid 7.8g

[0046] Vitamin B 6 0.5 grams

[0047] Dipotassium Glycyrrhizinate 1.0g

[0048] Naphazoline Hydrochloride 0.03g

[0049] Neostigmine Methosulfate 0.05g

[0050] Chlorpheniramine Maleate 0.1g

[0051] Polysorbate 80 0.5 g

[0052] Sodium chloride 8.0 g

[0053] Menthol 0.05g

[0054] Benzalkonium Chloride 0.1g

[0055] 1 mol / L sodium hydroxide solution Appropriate amount

[0056] Add water for injection to 1000ml

[0057]

[0058] Makes 1000ml

[0059] 【Method】

[0060] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0061] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added to t...

Embodiment 3

[0065] 【prescription】

[0066] Aspartic Acid 7.8g

[0067] Vitamin B 6 0.5 grams

[0068] Dipotassium Glycyrrhizinate 1.0g

[0069] Naphazoline Hydrochloride 0.03g

[0070] Neostigmine Methosulfate 0.05g

[0071]Chlorpheniramine Maleate 0.1g

[0072] Polysorbate 80 1.0 g

[0073] Sodium chloride 5.0 g

[0074] Menthol 0.2g

[0075] Benzalkonium Chloride 0.1g

[0076] 1 mol / L sodium hydroxide solution Appropriate amount

[0077] Add water for injection to 1000ml

[0078]

[0079] Makes 1000ml

[0080] 【Method】

[0081] 1. Weigh aspartic acid, dipotassium glycyrrhizinate, polysorbate 80, and menthol of the prescribed amount and place them in sterile containers and add water for injection to dissolve them.

[0082] 2. Weigh the prescribed amount of vitamin B 6 , naphazoline hydrochloride, neostigmine methosulfate, chlorpheniramine maleate, sodium chloride and benzalkonium chloride are added to the solut...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a compound asparticitin gutta and making method, which comprises the following parts: aspartic acid, vitamin B6, glycyrrhizin dipotassium, naphazoline hydrochloride, neostigmine methylsulfate, maleic chlorobenzenenamin, polysorbate 80, sodium chloride, menthol, benzachloridamine, sodium hydroxide solution and injecting water. The invention paves basis for scaling manufacturing of the compound asparticitin gutta further, which improves the productivity with stable content of maleic chlorobenzenenamin.

Description

【Technical field】 [0001] The invention belongs to the technical field of ophthalmic medication, and in particular relates to a compound aspartic and vigan eye drop and a preparation method thereof. 【Background technique】 [0002] Compound Asparagine Vigan Eye Drops is also called Weimin Eye Drops, Compound Aspart Pan-Gan Eye Drops, which contains L-Aspartate Potassium, Vitamin B 6 , Dipotassium Glycyrrhizinate, Naphazoline Hydrochloride, Chlorpheniramine Maleate, Neostigmine Methyl Sulfate. Its properties are light yellow clear liquid. The pharmacological effects of the compound aspartic and vegan eye drops include: improving the adjustment function of the eyes, eliminating eye fatigue, and reducing conjunctival hyperemia. Indications: eye fatigue, conjunctival hyperemia, chronic conjunctivitis, chronic blepharitis and allergic conjunctivitis. [0003] Clinical trials of compound aspart Vigan eye drops have shown that it can inhibit and eliminate eye fatigue caused by con...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61K9/08A61K47/34A61P27/02A61K31/198A61K31/27A61K31/4174A61K31/4402A61K31/4415A61K47/26
Inventor 杨文龙
Owner 江西闪亮制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com