The invention relates to a medicine for treating post stroke depression and an application thereof. The medicine is prepared from the following medicinal raw materials in parts by weight: 25-35 parts of salvia miltiorrhiza, 25-35 parts of rhizoma acori graminei, 10-20 parts of ligusticum wallichii, 10-20 parts of radix paeoniae alba, 10-20 parts of polygala tenuifolia, 5-15 parts of safflower carthamus, 5-15 parts of peach kernel, 7-17 parts of prepared rhizoma cyperi, 5-15 parts of radix bupleuri, 5-15 parts of fructus aurantii, 5-15 parts of radix curcumae, 4-8 parts of pericarpium citri reticulatae viride, 10-20 parts of endothelium corneum gigeriae galli, 25-35 parts of fructus cannabis, 25-35 parts of spina date seed and 25-35 parts of tuber fleeceflower stem. The invention further relates to a composition containing the medicine and fluoxetine hydrochloride. The medicine combined with antidepressant is capable of accelerating the drug effect taking speed, the dose can be controlled, the course of treatment can be shortened, the 'contradictory phenomena' and 'anticholinergic side effect' can be reduced, the effect of the medicine by combining comprehensive rehabilitation therapy is relatively remarkable in the treatment process, and the medicine is capable of gradually replacing the antidepressant in the later period of treatment.