10 results about "Anti cholinergic" patented technology

The present invention relates to a topical formulation comprising at least one anticholinergic compound for use in treating patients suffering from severe hyperhidrosis, wherein administration of the formulation to the patient comprises: a) an initial phase with a topical administration of a predetermined amount of the formulation 5 to 7 times per week for a total time period of less than six months: followed by b) a maintenance phase with a topical administration of the same amount of the formulation 1 to less than 5 times per week.

Intra-oral formulations comprising soft anticholinergic alkyl esters are useful for treating excessive drooling conditions in subjects, such as humans, suffering from sialorrhea. Preferably, at least one soft anticholinergic ester is provided in an effective amount or concentration in an anhydrous intra-oral formulation that can inhibit excessive drooling resulting from a condition known as sialorrhea.

Disclosed in the present invention is Bifidobacterium animalis subsp.lactis VB315, which is deposited in China General Microbiological Culture Collection Center on August 14, 2023, with the deposit number of CGMCC No. 28159. The Bifidobacterium animalis subsp.lactis VB315 of the present invention has a significant ability to produce butyric acid, can be used in the preparation of a drug for maintaining intestinal health, has relatively strong antibacterial ability and anticholinergic ability, and has great application prospects with regard to the preparation of medicines.

The application discloses application of triacetylandrographolide and a composition thereof in preparation of a medicine for relaxing airway smooth muscle, and belongs to the technical field of medicines. In view of the problems of obvious side effects and narrow treatment window of existing medicines, the application finds that triacetylandrographolide (3, 14, 19-Triacetylandrographolide, TAA) and the composition thereof have tracheal relaxation activity, and the triacetylandrographolide and the composition thereof play a relaxation role through non-competitive antagonism of a downstream signal path of a cholinergic receptor. The new mechanism provides a new idea for developing a new bronchial dilator for overcoming drug resistance of existing medicines. The TAA after preparation optimization can be used for treating or preventing airway obstructive diseases such as asthma, chronic obstructive pulmonary disease, bronchitis and acute lung injury.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis. 20 24 22 77 14 29 O ct 2 02 4 A B S T R A C T 2 0 2 4 2 2 7 7 1 4 2 9 O c t 2 0 2 4

Intra-oral formulations comprising soft anticholinergic alkyl esters are useful for treating excessive drooling conditions in subjects, such as humans, suffering from sialorrhea. Preferably, at least one soft anticholinergic ester is provided in an effective amount or concentration in an anhydrous intra-oral formulation that can inhibit excessive drooling resulting from a condition known as sialorrhea.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

The present invention relates to an anticholinergic compound such as Darifenicin for use in the treatment of a neuromuscular disorder (in particular amyotrophic lateral sclerosis or ALS) in a human subject, wherein the neuromuscular disorder is characterized by an impaired neuromuscular transmission and / or an denervation at the NMJ (neuromuscular junction) and the anticholinergic agent is administered after symptomatic onset.

Topical formulations comprising soft glycopyrrolates are useful for treating excessive sweating conditions in subjects, such as humans suffering from hyperhidrosis. Preferably, at least one soft anticholinergic agent is provided in an effective amount or concentration in an anhydrous formulation that can inhibit excessive perspiration resulting from a condition such as hyperhidrosis.

There is provided a pharmaceutical preparation comprising an anticholinergic agent and a ternary solvent, the ternary solvent comprising 5% to 15% v / v of a diol, 60% to 70% v / v of an alcohol, and 5% to 20% v / v of water. There is also provided a method of preparing a pharmaceutical preparation as disclosed herein, comprising the step of mixing an anticholinergic agent with a mixture containing an alcohol, a diol, water, a humectant, and a pH buffer at room temperature. There is also provided a method of suppressing non-pathological body odor in a mammal. There is also provided a method of treating apocrine secretion causing odor and reducing microbial overgrowth in a mammalian subject, and the use of the pharmaceutical preparation.