Biologically active chloroform fraction of an extract obtained from a mangroone plant Salvadora persica L

a technology of salvadora persica and chloroform fraction, which is applied in the directions of biocide, plant/algae/fungi/lichens, plant compositions, etc., can solve the problems of affecting the therapeutic affecting the effect of betulinic acid availability, and affecting the quality of the product, so as to enhance the sweetness and reduce the after taste of the produ

Inactive Publication Date: 2003-01-02
COUNCIL OF SCI & IND RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0014] The invention has a different approach for pharmacological screening of anti-arrhythmic activity on atrial tissues. The left atrium was used for electric stimulations rather than the right atrium which has the pacemaker. This method was found advantageous for longer survival of the atrium during experiments.

Problems solved by technology

These inventors mentioned that the researches directed t betulinic acid as therapeutic agent are hindered because the betulinic acid is available in very limited quantities and at a very high cost.

Method used

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  • Biologically active chloroform fraction of an extract obtained from a mangroone plant Salvadora persica L
  • Biologically active chloroform fraction of an extract obtained from a mangroone plant Salvadora persica L
  • Biologically active chloroform fraction of an extract obtained from a mangroone plant Salvadora persica L

Examples

Experimental program
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example 2

[0089] Collection of the mangrove plant Salvadora persica L from the coast of Goa, a state in India was along Ribandar, near the mouth of the Mandovi estuary, upstream. This species is ubiquitous to the coastal areas of Goa and was collected manually from the intertidal banks.

example 3

[0090] Processing of the collected mangroves were washed first with seawater followed by tap water. The undesired materials were sifted out while washing with tap water to get rid of the salts. The leaves, stems, and flowers of the associated mangrove plant were air dried. After drying, the plant material was cut into small pieces and immersed in the solvent 90% aqueous methanol for a week for extraction. Care was taken to ensure that these were properly soaked / dipped in the solvent and checked for putrefaction.

example 4

[0091] Extraction and preparation of crude extract was carried out by cold percolation method at room temperature and by solvent evaporation at a water bath (temperature 50.degree. C.) under reduced pressure. This helps in protection of any heat labile metabolite present in it. Re-extraction was done twice until the extract was concentrated under vacuum to obtain the crude extract.

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Abstract

The invention discloses a process of extracting, fractionating and purifying bioactive molecules from an associated mangrove plant, methods of screening for pharmacological activities of crude extract, its fractions and purified compounds and use of the chloroform fraction of the crude extract as anti-spasmodic, anti-arrhythmic and anti-cholinergic agent.

Description

[0001] The invention relates to biologically active chloroform fraction of extracts obtained from the plant Salvadora persica Linneaus 1753. The invention also provides a process for obtaining the crude extract and obtaining the chloroform fraction. Further, the invention provides pharmaceutical compositions, exhibiting biological activity. Related Art The associated mangrove plant, Salvadora persica Linneaus, 1753, belongs to the order Salvadoracea and are shrubs or small trees with white flowers frequent in degraded mangrove swamps and saline banks all over the west coast of India. Large numbers of marine plants have been examined for bioactive substances. Nazarine, F; Anita F; Rataboli, P. V.; Diniz D'Souza, R. S and Dhume; V. G., 1998 in Indian Journal of marine Sciences, 27: 499-501 have reported promising pharmacological activities in marine organisms from Indian waters.[0002] There are several patents available from all over the world related to processes and compounds from n...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/19A61K36/185
CPCA61K36/185Y10S514/906Y10S514/826
Inventor GOSWAMI, USHAFERNANDES, NAZARINE
Owner COUNCIL OF SCI & IND RES
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