160results about How to "Slow down the dissolution rate" patented technology

This invention is directed to advanced hemorrhage control wound dressings, and methods of using a producing same. The subject wound dressing is constructed from a non-mammalian material for control of severe bleeding. The wound dressing is formed of a biomaterial comprising chitosan for controlling severe bleeding. The kind of severe, life-threatening bleeding contemplated by this invention is typically of the type not capable of being stanched when a conventional gauze wound dressing is applied with conventional pressure to the subject wound. The wound dressing being capable of substantially stanching the flow of the severe life-threatening bleeding from the wound by adhering to the wound site, to seal the wound, to accelerate blood clot formation at the wound site, to reinforce clot information at the wound site and prevent bleed out from the wound site, and to substantially prohibit the flow of blood out of the wound site.

A positive-working imageable element comprises inner and outer layers and a radiation absorbing compound such as an IR absorbing dye. The inner layer includes a first polymeric material. The ink receptive outer layer includes a second polymeric binder comprising a polymer backbone and an —X—C(═T)—NR—S(═O)₂— moiety that is attached to the polymer backbone, wherein —X— is an oxy or —NR′— group, T is O or S, R and R′ are independently hydrogen, halo, or an alkyl group having 1 to 6 carbon atoms. After thermal imaging, the element can be developed using an alkaline developer. Use of the particular second polymeric binder reduces sludging in the developer. Its dissolution rate in the developer is slow enough to resist developer attack in the non-imaged areas of the outer layer but rapid enough for the second polymeric binder to be quickly loosened from imaged areas and kept suspended or dissolved for a considerable time.

A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

Improved taste masking of pharmaceutical compositions of unpleasant-tasting drugs and cyclodextrin is achieved by forming a mixture of drug and cyclodextrin wherein the drug's dissolution rate has been retarded, or the the cyclodextrin's dissolution rate has been enhanced, or by both.

This invention provides specifically substituted 1,2,4-thiadiazole derivatives for use in the treatment of an α-synucleopathy such as Parkinson's disease, diffuse Lewy body disease, traumatic brain injury, amyotrophic lateral sclerosis, Niemann-Pick disease, Hallervorden-Spatz syndrome, Down syndrome, neuroaxonal dystrophy, multiple system atrophy and Alzheimer's disease. This invention also provides various methods for producing such substituted 1,2,4-thiadiazole derivatives.

The invention discloses a preparation method and an application of a gypsum retarder. The gypsum retarder is prepared from a diacid or anhydride material and an ammoniacal material or L-aspartic acid; the retarder prepared by use of the preparation method is added to gypsum so as to increase the setting time of a gypsum building material and reduce the strength loss of a hardened gypsum body. The retarder is a water-soluble amino acid degradable polymer, has excellent biodegradability and is a green and environment-friendly polymer material. The molecular structure of the retarder contains a large number of groups such as carboxyl, carbonyl and acyl, and the groups can be combined with Ca<2+> into complexes so that the dissolution velocity of the gypsum can be reduced, the diffusion of Ca<2+> to gypsum crystals can be restricted and hydration of gypsum particles can be hindered, and therefore, the retarding effect of the retarder is realized. Meanwhile, the strength loss caused by structural degradation of gypsum holes due to a high water-gypsum ratio is reduced.

The invention belongs to a chemical additive, and relates to an anti-caking additive with slow release effect. The anti-caking additive with slow release effect is mainly characterized in that organicmodifiers with a certain weight percentages such as hydrocarbon compounds, grease and the like are evenly mixed with powdered materials such as calcium silicate and fly ash at a certain temperature by a wet method, and subject to dehydration, drying and crushed into a powder product, and the product is evenly added to various granulated chemical fertilizers for use, the product prevents chemicalfertilizers from caking after adding the product to the fertilizers in package and storage. The anti-caking additive has slow release effect after fertilization, and enhances fertilizer efficiency. The anti-caking additives has advantages of no toxic and side effect, no pollution, low cost, less usage and better anti-caking performance compared with other like products and has certain slow releaseeffect on the fertilizers. The anti-caking additive is also applicable to anti-caking for other grain products.

Solid compositions with improved physical stability comprise an amorphous, low-solubility drug, a poloxamer, and a stabilizing polymer. The compositions provide good physical stability during storage and concentration enhancement of dissolved drug when administered to an aqueous environment of use.

A combination oral liquid formulation of melatonin with a antihistaminic drug has been proposed as a sleep-aid agent. The solubility and stability of melatonin was improved by using cyclodextrin and adjusting the pH to a suitable value. The combination drug is expected to have a dual mode of action. The antihistaminic agent may help patient to fall asleep quickly and melatonin may be effective subsequently providing a sound sleep to the patient.

A leadless hyperthermia electronic solder and preparing method thereof are disclosed. The solder is composed of alloy elements according to flowing percentage by weight: 10-224546014f Sb, 1-84550160f Cu, 0.01-224446740f Ni, 0-0.012f X, residue percent of Sn; wherein X represents zero species, one species or composition of optimal several species of Ga, P and mixed rare earth; the fusion point of the solder is between 240 DEG C to 320 DEG C, the tensile strength is 58-84MPa; the preparing method of the solder is: thermal insulating the prepared each alloy element at a temperature ranging from 850 DEG C to 900 DEG C for 1-2 hours by using a vacuum melting furnace or an antivacuum smelting furnace to melt them sufficiently, and mixing them sufficiently before discharged from the furnace, pouring, solidifying to obtain the solder; the solder is made into at least one of solder master alloy, solder block, soldered ball, soldering ring, soldering foil, soldering powder or soldering cream; the solder is provided with a higher fusion point to improve the fusion activity of solder, enhanced credibility of device, good antioxidant ability and excellent humectation performance.

The invention relates to a gemini organic silicon defoamer. The gemini organic silicon defoamer is of an improved polyether organosilicon diamide sulfonate structure; hydrophilic groups are ethylene oxide, an amido bond and sulfonate; hydrophobic groups are polysiloxane and epoxypropane; through a plurality of hydrophilic groups, the low-temperature defoaming affect is good; through a comb structure, polyether-modified silicone oil can quickly spread on a gas-liquid interface of a foaming system, and locally intrudes to break foam, and the gemini organic silicon defoamer has better defoaming activity; through a macromolecular comb structure, the dissolution rate in a system is reduced and a continuous foam inhibition effect is generated. The gemini organic silicon defoamer is a silicone-modified defoamer which is good in defoaming and foam inhibiting properties, especially good in low-temperature defoaming and foam inhibiting effects.

The invention discloses paddy field floating granule as well as a preparation method and application of the paddy field floating granule. A processing preparation of slow-released floating granule is adopted by utilizing a modern mechanized processing process; the paddy field floating granule is prepared by taking a paddy rice striped rice borer prevention and treatment agent, fertilizer and a plant growth regulator as main effective components, adding auxiliary materials including a water-surface floating carrier, a binding agent, a dispersant, a slow releasing agent and the like, and compounding. In a utilization process of the paddy field floating granule provided by the invention, soil does not need to be blended and the paddy field floating granule is directly broadcasted; a medicament can be slowly released, is uniformly distributed in a paddy field and has the effects of killing striped rice borers, strengthening seedlings, and adjusting the growth of paddy rice; the paddy field floating granule has the effects of increasing the yield and improving the quality of the paddy rice, and reducing the labor intensity caused by independent application of the fertilizer and the plant growth regulator.

6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-{[5-(methylsulfonyl)pyridin-2-yl]methyl}-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide 4-methylbenzenesulfonate and a novel crystalline form thereof are disclosed together with processes for preparing such salt and form, pharmaceutical compositions comprising such a salt and form, and the methods of treatment using such a salt and form.

The invention relates to a quickly-dissolved anion polyacrylamide antiphase emulsion and a preparation method thereof. The preparation method comprises the following steps: (1) preparing an oil phaseand a water phase; (2) dripping the water phase into the oil phase to obtain a water in oil pre-emulsion; (3) filling the water in oil pre-emulsion with nitrogen to perform deoxidizing; (4) adding aninitiator to the water in oil pre-emulsion to initiate polyreaction; and (5) adding a phase reversing agent into a reaction mixture to obtain the quickly-dissolved anion polyacrylamide antiphase emulsion. The quickly-dissolved ionic polyacrylamide antiphase emulsion provided by the invention has high dissolution rate, the dissolution time in water is shorter than 1min and an instant dissolving effect for use can be realized.

A thermally dissolving method for selectively mining useful potassium chloride and part of magnesium chloride from potassium salt mine by use of shaft, 4 pipes and liquid bed layer includes such steps as arranging the halogen mining pipe, dissolving liquid pipe and heating pipe in shaft, filling anti-emulsifying agent to form a liquid bed layer in salt stratum, and filling the dissolving liquid while filling steam to dissolve the useful ore. Its apparatus is also disclosed.

The invention discloses a marine culture device equipped with a feed recovery drum. The marine culture device comprises a cylindrical culture box used for culturing, wherein the bottom part of the interior of the culture box is separated into the feed recovery drum through a partition plate; the marine culture device also comprises a feed distribution mechanism used for feeding a feed; a stirringbox is connected with and arranged above the feed distribution mechanism through a conveying pipe; the upper part of the stirring box is connected with a feeding hopper; one side of the interior of the feed recovery drum is connected with a water conveying pump; and the other side of the interior of the feed recovery drum is connected with a collection pipe which is connected with a liquid suctionpump. The marine culture device provided by the invention can effectively solve the death of a cultured animal due to turbidity of a culture water body, effectively improves the survival rate of thecultured animal, and can realize controllable feeding and recycling of the feed.

The invention provides a method for harmless treatment of barium slag through ardealite. The method includes the following steps that firstly, the barium slag is smashed, wherein the barium slag is thrown into a grinding machine, and the barium slag of 50 meshes is obtained; and secondly, water is injected into the barium slag, wherein water is injected into the ground barium slag so that the water content of the ground barium slag can range from 15.0% to 17.0 %. The ardealite is adopted for harmless treatment of the barium slag, so that cost is low, operation is simple, the source of the ardealite is wide, and a foundation is provided for stacking treatment of the barium slag; fixation of barium salt in the barium slag is achieved, meanwhile, the dissolution dissolubility of soluble phosphorus in the ardealite is also reduced, and the effect of treating waste with waste is achieved; and soluble barium in the barium slag exists mainly in the manner of sulfide or hydrosulfide, soluble sulfur and phosphorus (sulfate radicals and phosphate radicals) in the ardealite are utilized, the soluble barium is settled and solidified, the leaching toxicity of barium is harmless, the corrosivity(pH) is reduced as well, and the concentration of the soluble phosphorus is reduced.

Disclosed is a method for preparing NaY molecular sieve by in-situ crystallization, comprising steps of taking kaolin as raw material; adding de-ionized water and bonding agent; spraying and drying the prepared mixed slurry to obtain a kaolin microballoon; roasting the kaolin sprayed microballoon at 920-1000 DEG C for 2 hours to obtain the roasted kaolin microballoon; treating the roasted kaolin microballoon by inorganic acid at 30-55 DEG C; mixing and crystalizing the acid-treated kaolin microballoon, the silicon source, the alkali solution and guiding agent; filtering, washing and drying the filter cake to obtain the in-situ crystalized product. The NaY molecular sieve included in the prepared in-situ crystalized product is featured by small mean grain diameter and good stability; the prepared molecular sieve is applicable to the heavy oil fluid catalytic cracking.

A non-carbon, metal-based, high temperature resistant, electrically conductive and electrochemically active anode of a cell for the production of aluminum has a metal-based oxidation-resistant substrate to which an adherent multi-layer coating is applied prior to its immersion into the electrolyte and start up of the electrolysis by connection to the positive current supply. The multi-layer coating is obtainable from one or more applied layers selected from: a liquid solution, a dispersion in a liquid or a paste, a suspension in a liquid or a paste, and a pasty or non-pasty slurry, and combinations thereof, with or without heat treatment between two consecutively applied layers. At least one layer of the multi-layer coating contains a polymeric and/or a colloidal carrier. The coating is after final heat treatment electrically conductive and has during operation in the cell an electrochemically active surface for the oxidation of oxygen ions present at the surface of the anode.

Bioadhesive, closed-cell foam film, sustained release, delivery devices for administering an active agent or combination of active agents to a subject are provided. Methods for making such delivery devices and methods for using such delivery devices offering the controlled and sustained release of an active agent or combination of active agents to a subject, preferably a near zero-order release, are also provided.

The invention relates to oral sustained release granules using microcrystalline cellulose and ethyl cellulose as a carrier to be combined with active compositions. The invention solves the problem that the prior granule coating type sustained release insoluble drug is too slow in releasing from a skeleton, the release of the drug is affected by pH values and digestive hydrolysis speed, coating needs to be processed by special coating equipment which is expensive, has complex process, high requirement of operation and high rate of products with bad quality and is unfavorable to mass industrial production, and the like. In the invention, the microcrystalline cellulose and ethyl cellulose are combined to form a carrier and are matched with active compositions; the microcrystalline cellulose can accelerate the speed of the drug dissolving in a human body, while the ethyl cellulose can sustain the speed the drug dissolved in the human body, so that the absorption of the drug is improved through the cooperation of the microcrystalline cellulose and ethyl cellulose, the bioavailability is improved, the speed of the drug releasing in the human body is controlled, and the active compositions are given full play in the human body.