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Gold nanorod with surface finish rosinyl quaternary ammonium salt molecules and preparation method and application thereof

A technology of rosin-based quaternary ammonium salt and gold nanorods, which is applied in nanotechnology for materials and surface science, medical preparations containing active ingredients, nanotechnology, etc., can solve biological toxicity and limit the wide application of gold nanorods And other issues

Inactive Publication Date: 2014-08-27
珠海菲伯过滤材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the use of a large amount of surfactant CTAB in the process of preparing gold nanorods, free CTAB molecules are biotoxic to biomolecules such as cells and proteins, which limits the wide application of gold nanorods in medicine and other fields (Alkilany, Alaaldin M, Murphy, Catherine J. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? [J]. Journal of Nano-particle Research, 2010, 7(12), 2313-2333)

Method used

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  • Gold nanorod with surface finish rosinyl quaternary ammonium salt molecules and preparation method and application thereof
  • Gold nanorod with surface finish rosinyl quaternary ammonium salt molecules and preparation method and application thereof
  • Gold nanorod with surface finish rosinyl quaternary ammonium salt molecules and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 2:1

[0054] Step 1: N 2 100.0 g (0.28 mol) of L-pimaric acid was refluxed for 3 hours under heating and magnetic stirring at 180 °C; when the reaction was cooled to 120 °C, 27.5 g (0.28 mol) of maleic anhydride was added to the system successively, 400 mL acetic acid solution, 0.5 g (0.003 mol) p-toluenesulfonic acid solution, reflux heating at 120 °C for 12 hours to obtain a yellow solid; recrystallize the above solid twice with acetic acid solution, and vacuum dry at 40 °C for 12 hours to obtain a white solid .

[0055] Take 10.0 g (0.025 mol) of the above-mentioned white solid and dissolve it in 250 mL of absolute ethanol, then add 2.8 mL (0.025 mol) of N,N-dimethylethylenediamine, and heat at 85 ℃ and reflux under the condition of magnetic stirring After 5 hours, when the reaction was cooled to room temperature, a white precipitate...

Embodiment 2

[0061] Example 2: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 2.4:1

[0062] Steps 1 and 2 are as in Example 1 Steps 1 and 2;

[0063] Step 3: Add 100 L of 0.01 mol / L chloroauric acid solution and 1.88 mL of 0.2 mol / L cetyltrimethylammonium bromide (CTAB) solution to 6.25 mL of twice distilled water, mix well, and then Add 0.5 mL of 0.01 mol / L sodium borohydride solution, and shake after the addition to obtain a brownish-yellow solution, that is, the seed solution of gold nanorods, which is placed at 30 °C for 2 hours and set aside. Add 106.9 mL of twice distilled water and 7.425 mL of 0.01 mol / L HAuCl to the glass container 4 solution and 106.4 mL 0.2 mol / L CTAB solution, after mixing evenly, add 0.45 mL 0.01 mol / L silver nitrate and 1.35 mL 0.1 mol / L ascorbic acid solution, this solution is the growth solution, after the solution becomes colorless , add 1.8 mL of the above seed solution, mix wel...

Embodiment 3

[0066] Example 3: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 3:1

[0067] Steps 1 and 2 are as in Example 1 Steps 1 and 2;

[0068]Step 3: Add 100 L of 0.01 mol / L chloroauric acid solution and 1.88 mL of 0.2 mol / L cetyltrimethylammonium bromide (CTAB) solution to 6.25 mL of twice distilled water, mix well, and then Add 0.5 mL of 0.01 mol / L sodium borohydride solution, and shake after the addition to obtain a brownish-yellow solution, that is, the seed solution of gold nanorods, which is placed at 30 °C for 2 hours and set aside. Add 106.9 mL of twice-distilled water and 7.425 mL of 0.01 mol / L HAuCl to the glass container 4 solution and 106.4 mL 0.2 mol / L CTAB solution, after mixing evenly, add 0.90 mL 0.01 mol / L silver nitrate and 1.35 mL 0.1 mol / L ascorbic acid solution, this solution is the growth solution, after the solution becomes colorless , add 1.8 mL of the above seed solution, mix well, ...

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Abstract

Provided are a gold nanorod with surface finish rosinyl quaternary ammonium salt molecules and a preparation method and application thereof. The preparation method comprises a first step of preparation of the rosinyl quaternary ammonium salt molecules, a second step of preparation of gold nanorod solution, a third step of preparation of the gold nanorod with the surface finish rosinyl molecules, wherein the third step comprises the substeps of enabling the obtained 6-7 mL of gold nanorod solution to undergo ultrasonic treatment for 20 min, adding the prepared rosinyl quaternary ammonium salt molecules of 0.014 g, performing ultrasonic treatment, standing the solution for 2-3 days under the water bath conditions of 35-40 DEG C, and finally obtaining the brown red solution which is the 2 mg / mL gold nanorod solution with the surface finish rosinyl quaternary ammonium salt molecules. The gold nanorod with the surface finish rosinyl quaternary ammonium salt molecules has a near-infrared photothermal conversion effect, can be applied to the fields of bacterial resistance, organ transplantation and medical equipment and have biological activities of bacterial resistance and cancer resistance.

Description

[0001] technical field [0002] The invention relates to a gold nanorod whose surface is modified with a rosin-based quaternary ammonium salt molecule, a preparation method and an application thereof. [0003] Background technique [0004] Rosin is an important biomass resource, and its main components are abietic acids with diterpenoid structures such as abietic acid, pimaric acid, L-pimaric acid, long-leaved abietic acid, neoabietic acid and dehydroabietic acid. With the depletion of fossil resources, people are increasingly aware of the importance of replacing fossil resources with biomass resources when developing chemical products. Therefore, the modification of natural product rosin has become a research hotspot at home and abroad and has very important practical significance. [0005] Abietic acid is one of the main components of rosin. It has conjugated double bonds and carboxyl groups in the molecule and there are multiple chiral centers. Therefore, the double bon...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00A61K41/00A61P31/04A61P35/00C09K3/00B82Y40/00B82Y30/00
Inventor 陈莹冯晓燕王春鹏储富祥
Owner 珠海菲伯过滤材料有限公司
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