Gold nanorods with surface-modified rosin-based quaternary ammonium salt molecules, preparation method and application thereof

A technology of rosin-based quaternary ammonium salt and gold nanorods, which is applied in nanotechnology for materials and surface science, medical preparations containing active ingredients, nanotechnology, etc., and can solve the problems that limit the wide application of gold nanorods and biological toxicity. And other issues

Inactive Publication Date: 2016-01-13
珠海菲伯过滤材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the use of a large amount of surfactant CTAB in the process of preparing gold nanorods, free CTAB molecules are biotoxic to biomolecules such as cells and proteins, which limits the wide application of gold nanorods in medicine and other fields (Alkilany, AlaaldinM, Murphy, CatherineJ. Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? [J]. Journal of Nano-particle Research, 2010, 7(12), 2313-2333)

Method used

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  • Gold nanorods with surface-modified rosin-based quaternary ammonium salt molecules, preparation method and application thereof
  • Gold nanorods with surface-modified rosin-based quaternary ammonium salt molecules, preparation method and application thereof
  • Gold nanorods with surface-modified rosin-based quaternary ammonium salt molecules, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 2:1

[0049] Step 1: N 2 Protection, heating at 180°C and magnetic stirring, 100.0g (0.28mol) of L-pimaric acid was refluxed for 3 hours; when the reaction was cooled to 120°C, 27.5g (0.28mol) of maleic anhydride, 400mL Acetic acid solution, 0.5g (0.003mol) p-toluenesulfonic acid solution, heated under reflux at 120°C for 12 hours to obtain a yellow solid; recrystallize the above solid twice with acetic acid solution, and vacuum dry at 40°C for 12 hours to obtain a white solid.

[0050] Take 10.0 g (0.025 mol) of the above white solid and dissolve it in 250 mL of absolute ethanol, then add 2.8 mL (0.025 mol) of N,N-dimethylethylenediamine, and heat at 85 ° C and reflux under magnetic stirring conditions for 5 Hours, when the reaction was cooled to room temperature, a white precipitate was obtained, and then recrystallized twice with abso...

Embodiment 2

[0055] Example 2: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 2.4:1

[0056] Steps 1 and 2 are as in Example 1 Steps 1 and 2;

[0057] Step 3: Add 100L 0.01mol / L chloroauric acid solution and 1.88mL 0.2mol / L cetyltrimethylammonium bromide (CTAB) solution to 6.25mL double-distilled water, mix well, and then add Shake 0.5mL of 0.01mol / L sodium borohydride solution after addition to obtain a brownish-yellow solution, that is, the seed solution of gold nanorods, which is placed at 30°C for 2 hours and set aside. Add 106.9mL of twice distilled water and 7.425mL of 0.01mol / L HAuCl to the glass container 4 solution and 106.4mL0.2mol / L CTAB solution, after mixing evenly, add 0.45mL0.01mol / L silver nitrate and 1.35mL0.1mol / L ascorbic acid solution, this solution is the growth solution, after the solution becomes colorless , adding 1.8mL of the above seed solution, mixing evenly, and standing overnight at a...

Embodiment 3

[0059] Example 3: Preparation of gold nanorods with a surface-modified rosin-based quaternary ammonium salt molecule with an aspect ratio of 3:1

[0060] Steps 1 and 2 are as in Example 1 Steps 1 and 2;

[0061] Step 3: Add 100L 0.01mol / L chloroauric acid solution and 1.88mL 0.2mol / L cetyltrimethylammonium bromide (CTAB) solution to 6.25mL double-distilled water, mix well, and then add Shake 0.5mL of 0.01mol / L sodium borohydride solution after addition to obtain a brownish-yellow solution, that is, the seed solution of gold nanorods, which is placed at 30°C for 2 hours and set aside. Add 106.9mL of twice distilled water and 7.425mL of 0.01mol / L HAuCl to the glass container 4 solution and 106.4mL0.2mol / L CTAB solution, after mixing evenly, add 0.90mL0.01mol / L silver nitrate and 1.35mL0.1mol / L ascorbic acid solution, the solution is the growth solution, after the solution becomes colorless , adding 1.8mL of the above seed solution, mixing evenly, and standing overnight at a co...

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Abstract

Gold nanorods with surface-modified rosin-based quaternary ammonium salt molecules and their preparation methods and applications are prepared by the following methods: (1) preparation of rosin-based quaternary ammonium salt molecules; (2) preparation of gold nanorod solutions; (3) ) Preparation of gold nanorods with surface-modified rosin-based molecules: ultrasonically treat 6-7 mL of the gold nanorod solution obtained above for 20 minutes, add 0.014 g of the prepared rosin-based quaternary ammonium salt molecules, sonicate, and 35-40 ° C in a water bath After standing for 2-3 days under the condition, the finally obtained brown-red solution is 2 mg / mL gold nanorod solution of surface-modified rosin-based quaternary ammonium salt molecules. The rosin-based quaternary ammonium salt molecule surface-modified gold nanorods of the present invention have near-infrared photothermal conversion effects, can be applied to the fields of antibacterial, organ transplantation, medical equipment and the like, and have antibacterial and anticancer biological activities.

Description

technical field [0001] The invention relates to a gold nanorod whose surface is modified with a rosin-based quaternary ammonium salt molecule, a preparation method and an application thereof. Background technique [0002] Rosin is an important biomass resource, and its main components are abietic acids with diterpenoid structures such as abietic acid, pimaric acid, L-pimaric acid, long-leaved abietic acid, neoabietic acid and dehydroabietic acid. With the depletion of fossil resources, people are increasingly aware of the importance of replacing fossil resources with biomass resources when developing chemical products. Therefore, the modification of natural product rosin has become a research hotspot at home and abroad and has very important practical significance. [0003] Abietic acid is one of the main components of rosin. It has conjugated double bonds and carboxyl groups in the molecule and there are multiple chiral centers. Therefore, the double bonds and carboxyl gro...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/00A61K41/00A61P31/04A61P35/00C09K3/00B82Y40/00B82Y30/00
Inventor 陈莹冯晓燕王春鹏储富祥
Owner 珠海菲伯过滤材料有限公司
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