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Mix-configuration ginsenoside Rh2 and uses thereof

A technology of ginsenoside and configuration, applied in the field of plant extract ginsenoside

Active Publication Date: 2009-05-13
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no ginsenoside Rh 2 Monomer as raw material to produce medicine

Method used

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  • Mix-configuration ginsenoside Rh2 and uses thereof
  • Mix-configuration ginsenoside Rh2 and uses thereof
  • Mix-configuration ginsenoside Rh2 and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Mixed configuration ginsenoside Rh of the present invention 2 , the content determined by high performance liquid chromatography is 90.8%, of which the R configuration content is 40.86%, the S configuration content is 49.94%, and the ratio of R configuration to S configuration is 4.5:5.5. Mix with the auxiliary materials according to the ratio in the table below, put them in a ball mill and grind for 2 hours, pass through a 120-mesh sieve, mix thoroughly, fill them into empty capsule shells, and obtain the required ginsenoside Rh 2 capsule.

[0043] Component / Amount (g) Recipe 1 Recipe 2 Recipe 3 Recipe 4 Recipe 5 Recipe 6 Ginsenoside Rh 2 100 90 80 70 100 85 Povidone 80 60 — — 100 50 Low-substituted hydroxypropyl cellulose 80 100 100 150 100 80 microcrystalline cellulose 80 50 60 50 80 40 starch 450 — 480 — 510 500 Sodium carboxymethyl starch — 40 40 40 30 40 Micropowder silic...

Embodiment 2

[0045] Mixed configuration ginsenoside Rh of the present invention 2 , the content determined by high performance liquid chromatography is 80%, of which the R configuration content is 47.2%, the S configuration content is 32.8%, and the ratio of R configuration to S configuration is 5.9:4.1. Weigh the mixed configuration ginsenoside Rh according to the formula in the table below 2 Dissolve in the excipients to form a uniform oil solution, and use an automatic rotary capsule rolling machine or capsule dripping method to obtain the required ginsenoside Rh 2 Softgels.

[0046] Component / Amount (g) Recipe 1 Recipe 2 Recipe 3 Recipe 4 Recipe 5 Recipe 6 Ginsenoside Rh 2 100 100 100 100 100 100 polyethylene glycol 100 — 80 — — — peanut oil — — 500 — — — linseed oil — — — 80 80.00 — hydrogenated vegetable oil — 900 — 820 800 850 Corn oil 750 — — — — — Vitamin E 1 2 4 — 1 —

Embodiment 3

[0048] Mixed configuration ginsenoside Rh of the present invention 2 , the content determined by high performance liquid chromatography is 89.6%, of which the R configuration content is 49.28%, the S configuration content is 40.32%, and the ratio of R configuration to S configuration is 5.5:4.5. Weigh the mixed configuration ginsenoside Rh according to the formula in the table below 2 Mix the powder and auxiliary materials in proportion, grind them in a ball mill for 2 hours, pass through a 120-mesh sieve, and make granules with a particle size of 40-80 mesh through dry granulation or a one-step granulator, and add 0.5-1.0% hard Magnesium fatty acid, mixed and granulated, compressed into tablets, film-coated, to obtain the required ginsenoside Rh 2 tablet.

[0049] Component / Amount (g) Recipe 1 Recipe 2 Recipe 3 Recipe 4 Recipe 5 Recipe 6 Ginsenoside Rh 2 100 100 100 100 100 100 polyethylene glycol — — 80 — — 50 Crystalline C...

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Abstract

The invention provides compound configuration ginsenoside Rh2, which relates to plant extracts - ginsenoside, in particular to compound configuration ginsenoside. The invention also relates to application of ginsenoside with the configuration. The compound configuration ginsenoside mainly comprises 20(S) - ginsenoside Rh2 and 20 (R) - ginsenoside Rh2. The compound configuration ginsenoside is characterized in that the mass ratio of the 20 (R) - ginsenoside Rh2 and the 20(S) - ginsenoside Rh2 is 6:4 to 4:6. The compound configuration ginsenoside Rh2 can be applied to preparation of medicines for anticancer drug synergism and attenuation, medicines for treating cancer, medicines for preventing cancer cell transfer and medicines for enhancing the immunologic effect of the organism. The compound configuration ginsenoside has good effects of cancer resistance attenuation, cancer cell inhibition and cancer cell transfer prevention, and can enhance the immunologic effect of the organism.

Description

technical field [0001] The invention relates to a plant extract ginsenoside, in particular to a mixed configuration ginsenoside. The present invention also relates to the application of this combined configuration ginsenoside. technical background [0002] Japanese natural medicine expert Kitagawa Hoon and others first discovered ginsenoside Rh from red ginseng in 1981. 2 (ginsenoside-Rh 2 ), its content in red ginseng is about 1 / 100,000, and it has been reported that it has good antitumor activity. Since then, pharmacological studies have shown that ginsenoside Rh 2 The inhibitory effect on tumor cells, the induction of differentiation, the induction of apoptosis, the anti-invasion and metastasis, the attenuation and synergistic effect, and the effect of significantly improving the body's immunity are different from traditional anti-tumor drugs. These characteristics are exactly what we are pursuing in the research of anticancer drugs, a new potential chemotherapy drug....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P35/00A61P37/02C07J17/00
Inventor 张春雨高崇昆唐文旭董汛宾燕
Owner YUNNAN BAIYAO GROUP
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