Compound as Hedgehog path inhibitor, medicine composition containing same and application thereof

A technology for compounds and solvates, applied in the field of compounds and compositions containing the compounds, can solve problems such as insignificant therapeutic effects
CN101993415AActive Publication Date: 2011-03-30BEIJING HANMI PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING HANMI PHARMA CO LTD
Publication Date
2011-03-30

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Abstract

The invention provides a compound of general formula I as an inhibitor and a preparation method thereof. The compound is used for inhibiting a Hedgehog signal path and can provide a new medicine for clinic effective cancer resistance. The invention also provides a medicine composition as an inhibitor, which contains the compound I as an effective ingredient and can be used for inhibiting the Hedgehog signal path so as to resist cancer. In addition, the invention also provides an application of the compound in the preparation of the medicine for inhibiting the Hedgehog signal path.
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Description

technical field

[0001] The present invention relates to a compound, in particular to a compound as an inhibitor and to a composition comprising the compound (C07D 521 / 00). Background technique

[0002] The hedgehog signaling pathway discovered in Drosophila in 1980 plays an important regulatory role in the process of cell proliferation, differentiation and determination of cell fate during animal embryogenesis. A properly functioning Hedgehog signaling pathway is necessary for the formation of vital organs such as the brain, limbs, lungs, skin, and prostate (Ingham PW & McMahon AP (2001) Genes & Development 15, 3059-3087). Although the level of the Hedgehog signaling pathway in adults is much lower than that in embryos, this pathway still plays a vital role in the proliferation and renewal of adult tissues. Stem cells are a kind of pluripotent cells with self-renewal ability, that is, stem cells maintain an undifferentiated state and have the ability to proliferate. Under a...

Claims

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