Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chinese medicinal composition for treating thrombopenia as well as preparation method and application of composition

A technology of thrombocytopenia and composition, which is applied in the field of traditional Chinese medicine composition for treating thrombocytopenia and its preparation, can solve the problems that the quantity and quality of platelets cannot be improved, achieve no toxic side effects, good stability, and improve bleeding symptoms Effect

Active Publication Date: 2013-04-24
SHANGHAI UNIV OF T C M
View PDF6 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some Chinese herbal medicines treat the symptoms but not the root cause, which can improve the bleeding symptoms clinically, but cannot improve the quantity and quality of platelets.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chinese medicinal composition for treating thrombopenia as well as preparation method and application of composition
  • Chinese medicinal composition for treating thrombopenia as well as preparation method and application of composition
  • Chinese medicinal composition for treating thrombopenia as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] a) Extraction and purification of madder

[0026] Take 300 kg of madder medicinal material, reflux extraction with 95% ethanol aqueous solution with a volume fraction of 10 times the amount of medicinal material, and extract twice for 1.5 hours each time; combine the extracts, recover ethanol under reduced pressure, and obtain crude madder extract; use 300 L of water Dissolve this medicinal extract, absorb through macroporous adsorption resin column, wash off water-soluble impurity with deionized water earlier after adsorption is complete, be 90% ethanol aqueous solution elution with the volume fraction of 8 times volume again, collect eluent, reduce Press to recover ethanol; dry to obtain 5.0 kg of madder extract, which is dark brown solid.

[0027] Referring to the TLC identification method under the Rubia item of the 2010 edition of "Chinese Pharmacopoeia", prepare the test solution and the reference medicinal material solution of the appropriate solubility of the ex...

Embodiment 2

[0034] Taking madder and comfrey with a mass ratio of 1:1 as raw materials, according to the extraction and refining process of the present invention, 50 g of madder extract and 100 g of comfrey extract were obtained; the two were mixed evenly, and 80 g of starch, paste Essence 120g, sodium carboxymethyl starch 20g, with the ethanol aqueous solution of 50% by volume fraction as binder, make soft material, cross 14 mesh sieves and make granule, dry, add appropriate amount of talcum powder and press tablet, plain tablet film coating, The coated tablet containing the traditional Chinese medicine composition of the present invention is obtained.

Embodiment 3

[0036] Taking madder and comfrey with a mass ratio of 1:1 as raw materials, according to the extraction and refining process of the present invention, 76.7 g of madder extract and 153.3 g of comfrey extract were obtained; the two were mixed evenly, and added lactose 480g, 100g of mannitol, 100g of cross-linked PVP, appropriate amount of 95% ethanol, 15g of magnesium stearate, compressed into tablets, to obtain a solid dispersible tablet containing the traditional Chinese medicine composition of the present invention.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a Chinese medicinal composition for treating thrombopenia as well as a preparation method and application of the composition. The Chinese medicinal composition is prepared from madder and lithospermum in a mass ratio of (1:3)-(3:1). The composition is prepared by preparing and then uniformly mixing refined madder extract and refined lithospermum extract. Pharmacological and pharmacodynamic experimental results show that the composition of different dose groups can remarkably shorten the bleeding and clotting time of mice, the high or medium dose group can remarkably shorten the thrombin time (TT), the prothrombin time (PT) and the activated partial thromboplastin time (APTT) of chronic idiopathic thrombocytopenic purpura (ITP) model rats, and the high or medium dose group has an effect of remarkably improving the platelets of the rats. Thus, the Chinese medicinal composition can be used for preparing a medicinal preparation for treating the thrombopenia, and particularly can be used for preparing a medicinal preparation for treating immune thrombocytopenia.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating thrombocytopenia and its preparation method and application, belonging to the technical field of traditional Chinese medicine. Background technique [0002] Thrombocytopenia is a disease caused by decreased platelets in peripheral blood (<100,000 / μl) leading to bleeding in the skin, mucous membranes and internal organs. Violet blood blisters on the mucous membrane and tongue are common clinical diseases characterized by coagulation dysfunction and bleeding. Severe cases can cause massive hemorrhage, which is life-threatening. It accounts for about 30% of bleeding diseases in clinical practice. [0003] The causes of thrombocytopenia can be divided into: (1) Decreased or ineffective death of platelet production: including hereditary and acquired. Acquired thrombocytopenia is caused by certain factors such as dr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P7/04
Inventor 季光浦益琼张彤王冰李国文陶建生
Owner SHANGHAI UNIV OF T C M
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com