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Application of sibiricose A1, sibiricose A5 and tenuifoliside A in preparing tristimania treating products

A technology for depression and products, applied in the application field of preparing products for treating depression, can solve problems such as high price, poor antidepressant effect, toxic and side effects, etc.

Inactive Publication Date: 2009-12-02
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing antidepressants are mainly: tricyclics (TCAs), selective 5-HT reuptake inhibitors (SSRIs), monoamine oxidase inhibitors (MAOIs), they all have different degrees of toxic and side effects, and are expensive
In addition, there are still about 1 / 3 of depressed patients who do not respond well to these antidepressants in clinical use

Method used

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  • Application of sibiricose A1, sibiricose A5 and tenuifoliside A in preparing tristimania treating products
  • Application of sibiricose A1, sibiricose A5 and tenuifoliside A in preparing tristimania treating products
  • Application of sibiricose A1, sibiricose A5 and tenuifoliside A in preparing tristimania treating products

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Experimental program
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Embodiment

[0009] Embodiment: Separation and activity research of oligosaccharide ester monomer

[0010] 1. Materials:

[0011] 1.1 Animals: KM mice, ♂, weighing 18-22 g, provided by the Animal Center of the Academy of Military Medical Sciences, certificate number: SCXK-(Army) 2002-001.

[0012] 1.2 Drugs and reagents Desipramine (DMI), Apomorphine (APO), Yohimbine (Yohinbin, YOH), 5-hydroxytryptophan (5-hydroxytryptophan, 5-HTP), Pagiline (pargyline), are all products of sigma company.

[0013] 1.3 Instruments and materials

[0014] Fab-Ms mass spectrometer Micromass ZabSpec (USA), nuclear magnetic resonance instrument JNM-ECA-400 superconducting instrument (Japan), dextran gel Sephadex LH-20, column chromatography silica gel (200-300 mesh) and thin-layer chromatography silica gel F254 (Qingdao Ocean Chemical Plant), RPMI1640 medium (Gibco), Multiskan MK3 microplate reader (USA), SANYOMCO-15ACCO2 incubator (Japan).

[0015] Polygala is the dried root of Polygala polygala tenuifolia ...

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Abstract

The invention discloses a new medicinal application of sibiricose A1, sibiricose A5 and tenuifoliside A, in particular to an application of sibiricose A1, sibiricose A5 and tenuifoliside A in preparing tristimania treating products. The sibiricosee A1, the sibiricose A5 and the tenuifoliside A have a better treatment function for tristimania caused by various reasons; the sibiricose A5 and the tenuifoliside A have a certain protecting function for PC 12 cells damaged by glutamic acid; and the sibiricosee A1, the sibiricose A5 and the tenuifoliside A all can shorten the tail-hanging resting time and the swim resting time of a mouse. Compared with a mould group, a dose group has marked difference in statistics and dose dependence and shows a better anti-depression effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly relates to Siberia polygala sugar A1 (sibiricose A1 (compound 1), Siberia polygala sugar A5 (sibiricose A5 (compound 2), tenuifoliside A (compound 3) extracted from natural plants and / or obtained in chemical synthesis. ), specifically relate to their application in the preparation of products for the treatment of depression. technical background [0002] Depression is the main type of affective disorder, characterized by significant and persistent low mood. In 1996, the World Health Organization (WHO) released a survey on the "Global Burden of Disease", which showed that depression had become the fourth largest disease in the world in 1990, accounting for 3.7% of the total disease burden; It is the second largest disease after ischemic heart disease, accounting for 5.7% of the total disease burden. Depression will be one of the most serious human diseases in the 21st centu...

Claims

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Application Information

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IPC IPC(8): A61K31/7024A61P25/24
Inventor 刘屏郭代红胡园穆丽华陈宜鸿廖红波王东晓
Owner GENERAL HOSPITAL OF PLA
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