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Polynucleotide microcapsule for treating diseases of livestock and poultry and preparation method thereof

A technology for polynucleotide and livestock and poultry diseases, which is applied in the field of polynucleotide sustained-release microcapsules and the preparation thereof, can solve the problem that the polynucleotide sustained-release microcapsules have not yet been retrieved, and the like, and achieves a reduction in breeding cost, prolong the duration of action, and improve the effect of the cure rate

Inactive Publication Date: 2009-07-08
NANJING AGRICULTURAL UNIVERSITY +1
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

No relevant patents related to the application of polynucleotide sustained-release microcapsules in livestock and poultry have been retrieved so far

Method used

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  • Polynucleotide microcapsule for treating diseases of livestock and poultry and preparation method thereof
  • Polynucleotide microcapsule for treating diseases of livestock and poultry and preparation method thereof

Examples

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Embodiment Construction

[0020] 1) Preparation of polynucleotide solution

[0021] Weigh 0.5g each of polyinosinic acid (250g / barrel, Jiangmen Qunke Pharmaceutical Co., Ltd.) and polycytidylic acid (250g / barrel, Jiangmen Qunke Pharmaceutical Co., Ltd.) 50ml of sodium chloride-phosphate buffer (pH7.2) at ℃±1℃ [take 1.546g of disodium hydrogen phosphate, sodium dihydrogen phosphate (NaH 2 PO 4 2H 2 O) 0.262g, sodium chloride 8.768g, add water to dissolve and dilute to 1000ml], stir to fully dissolve, keep the temperature for 30min; mix the two solutions, keep at 45°C±1°C for 40min, cool to room temperature to obtain The solution is a 10 mg / ml polynucleotide solution.

[0022] 2) Preparation of polynucleotide-ethyl fiber soft material

[0023] Measure 13ml of the above polynucleotide solution and add it to 10.0g ethyl fiber (pharmaceutical grade, viscosity 10Cps, Shandong Ruitai Chemical (Group) Co., Ltd.) to prepare a soft material, dry at 45°C for 12h, and grind to obtain Ethyl cellulose dry powde...

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Abstract

The invention relates to a polynucleotide microcapsule for treating animal disease and a preparation method thereof, belonging to the technical field of veterinary medicament preparation. Polyinosinic acid and polycytidylic acid are weighted and are added into preheated sodium chloride-phosphate buffer solution, and polynucleotide solution is prepared; the polynucleotide solution is added into ethyl cellulose to prepare soft wood and dry powder is prepared; the dry powder and magnesium stearate are added into ice-bath acetone to obtained a mixture, the mixture is stirred and slowly added into whiteruss containing 2%Span-80 surface active agent; and polynucleotide microcapsule is obtained by a method of in-liquid drying. The invention effectively prolongs the acting time of medicament within human body, decrease the applied time of the medicament and achieves the aims of long acting and sustained release. Experiments prove that the dead rate of the high dose group or the medium dose group of the polynucleotide microcapsule is obviously lower than that of an infectious control group. The cure rate is high, both are 80%, and the effective rate of the two groups are 100%. Experiments prove that the medicament of the invention is safe.

Description

technical field [0001] The invention belongs to the field of veterinary biotechnology, and in particular relates to a polynucleotide slow-release microcapsule used in treating livestock and poultry diseases and a preparation method thereof. The polynucleotide slow-release microcapsule is prepared with polynucleotide as raw material and ethyl fiber as capsule material. Background technique [0002] With my country's accession to WTO, the domestic livestock and poultry breeding industry will face greater challenges. According to FAO statistical data, in the past 20 years, my country's meat production has increased by more than 4 times, of which the annual breeding volume of livestock and poultry is nearly 5 billion, and the number of live pigs is nearly 600 million. The production capacity has been greatly improved. The market supply and demand balance has exceeded demand. [0003] However, the severe losses caused by livestock and poultry diseases have become the main obstac...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/7088A61P31/14A61P11/00A61P1/00C07H21/00
CPCY02A40/70
Inventor 鲍恩东吕英军苏建东
Owner NANJING AGRICULTURAL UNIVERSITY
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