Applications of lectuce tea total glycosides and method of preparing the same

A technology for total glycosides of Kudingcha and Kudingcha, applied in the new application and preparation field, can solve the problems of prolonging production time, affecting separation effect, organic solvent residue and the like, and achieving the advantages of shortening time, reducing cost and safe production process. Effect

Inactive Publication Date: 2008-09-03
海南阿苷饮品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The degreasing link will bring many problems in large-scale production: 1) organic solvent residue; 2) petroleum ether is a flammable liquid, which will bring s...

Method used

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  • Applications of lectuce tea total glycosides and method of preparing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 The effect of total glycosides of Kudingcha on the levels of MDA, GSH and TG in the alcoholic liver of Kunming mice induced by ethanol

[0028] Test sample: the sample is Kudingcha total glycosides.

[0029] Dosage: There are three dosage groups of 0.22, 0.44, and 1.32g / kg BW, which are 5, 10, and 30 times the recommended daily dose for the human body. A blank control group and an ethanol control group are also set up. The doses are: 1) blank control group 0.00g / kgBW; 2) ethanol control group 0.00g / kg BW; 3) low dose group 0.22g / kg BW; 4) medium dose group 0.44g / kgBW; 5) high dose Group 1.32g / kg BW.

[0030] Preparation of test substance: Dilute 2.64g of test sample to 40.0ml with purified water every day to prepare the test substance of the high-dose group, then dilute 5.0 and 10.0ml of the test substance of the high-dose group to 30.0ml with purified water respectively. Low and middle dose groups of test substances.

[0031] The route of administration of...

Embodiment 2

[0036] Example 2 The effect of total glycosides of Kudingcha on the levels of ALT and AST in Kunming mice fatty liver induced by carbon tetrachloride

[0037] Test sample: the sample is Kudingcha total glycosides.

[0038] Dosage: There are three dosage groups of 0.22, 0.44, and 1.32g / kg BW, which are 5, 10, and 30 times the recommended daily dose for the human body. A blank control group and an ethanol control group are also set up. The doses are: 1) blank control group 0.00g / kgBW; 2) ethanol control group 0.00g / kg BW; 3) low dose group 0.22g / kg BW; 4) medium dose group 0.44g / kgBW; 5) high dose Group 1.32g / kg BW.

[0039] Preparation of test substance: Dilute 2.64g of test sample to 40.0ml with purified water every day to prepare the test substance of the high-dose group, then dilute 5.0 and 10.0ml of the test substance of the high-dose group to 30.0ml with purified water respectively. Low and middle dose groups of test substances.

[0040] The way of giving the test subst...

Embodiment 3

[0046] Embodiment 3 The preparation method of Kudingcha total glycosides of the present invention comprises the following steps:

[0047] A, weigh and pulverize the purchased Kudingcha that meets the quality standard requirements, and pass through a 20-mesh sieve to obtain raw materials;

[0048] B. Use 5 times the amount of 80% edible alcohol to reflux extract twice at 60°C, the first extraction time is 2 hours, the second extraction time is 1.5 hours, and the two extractions are combined;

[0049] C. Filter the above extract, concentrate under reduced pressure, control the concentration temperature to be 60°C, and the concentration pressure is -0.085mPa, and concentrate to ethanol extract with a relative density of 1.1 to 1.2;

[0050] D, the obtained concentrated extract, add 5 times the amount of pure water and fully stir for 15 minutes, after standing for 45 minutes, pour out the supernatant night, do this twice, combine the two aqueous solutions, and carry out centrifuga...

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Abstract

The invention relates to the application of Ilex latifolia total glycosides and a preparation method thereof. Studies finds that the Ilex latifolia total glycosides can reduce the content of malonaldehyde (MDA) and triglyceride (TG) in liver, increase the content of reduced glutathione (GSH) in each dose group of liver, reduce the content of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in liver, and has alcoholic hepatitis and fatty liver resisting activity. Compared with the prior art, the invention provides a new application of Ilex latifolia total glycosides in preparing drugs and/or functional food for preventing and/or treating alcoholic hepatitis and fatty liver; the invention also provides a preparation method of the Ilex latifolia total glycosides with the advantages of safe and simple process, saved cost, high efficiency, and easy quality control; and the invention further provides a preparation of the Ilex latifolia total glycosides.

Description

【Technical field】 [0001] The present invention relates to kudingcha total glycosides, in particular to its new application in the preparation of medicines and / or functional foods and its preparation method. 【Background technique】 [0002] Kudingcha is a unique resource species in China. So far, it has been drunk as a folk traditional tea for more than 2,000 years, and it is a unique and large resource species in my country. As listed in the table, the original plant of Kudingcha belongs to 5 families, 5 genera and 10 species [Yunnan Botanical Research 1992; 14(3): 328 336]. [0003] The original plant of Kudingcha in various parts of my country [0004] Chinese name Latin scientific name Branch name 1 privet Ligustrum pedunculare Rehd. Oleaceae 2 Amethyst privet L. purpurascens Y.C. Yang Oleaceae 3 japanese hairy privet L. japonicum Thunb var. pubescens Koidz. Oleaceae 4 thick pr...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P1/16A23L1/30C07H1/08A23L33/105
Inventor 贺震旦池银珠
Owner 海南阿苷饮品有限公司
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